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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 3 | Temporal and Spatial Distribution of the Late Devonian (Famennian) Strata in the Northwestern Border of the Junggar Basin, Xinjiang, Northwestern China显示文摘The base of the Saerba Member(Mbr) of the Hongguleleng Formation(Fm.) probably lies in the Famennian Palmatolepis crepida Zone;the Longkou Mbr is probably a sedimentary wedge that thins out northwards;the Duguer Mbr has an approximate age from the upper part of the Pa.marginifera Zone or the Lower Pa.rugosa trachytera Zone through the top of the Pa.perlobata postera Zone;the Wulan Mbr has an age approximately corresponding to the whole Pa.gracilis expansa Zone.In the Bulongguoer section,the Lower Mbr of the Hongguleleng Fm.corresponds to Famennian Pa.crepida Zone through Pa.marginifera Zone;the Middle Mbr probably ranges from the Pa.r.trachytera Zone through the Pa.g.expansa Zone.The basal Namu Mbr of the Heishantou Fm.is probably the product during and after the Hangenberg Event in the upper part of the Siphonodella praesulcata Zone,which is still within the Devonian.In this context,the underlying Chasi Mbr may approximately correspond to the lower part of the S.praesulcata Zone(before the Hangenberg Event).Lateral distribution of strata indicates that the Upper Devonian in the Gennaren and Saerba areas each constitutes a structure of syncline,which differs from the previous recognition of a monocline structure. | MA Xueping ZHANG Meiqiong ZONG Pu ZHANG Yubo Lü Dan | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 9 |
| 4 | Applications of finite element simulation in orthopedic and trauma surgery显示文摘Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement. | Antonio Herrera Elena Ibarz José Cego?ino Antonio Lobo-Escolar Sergio Puértolas Enrique López Jesús Mateo Luis Gracia | 2012 | World Journal of Orthopedics2012，3，4： | 8 |
| 5 | A New Oviraptorid Dinosaur (Theropoda: Oviraptorosauria) from the Late Cretaceous of Jiangxi Province, Southern China显示文摘A new oviraptorid dinosaur Jiangxisaurus ganzhouensis gen. et sp. nov., is erected based on a partial skeleton from the Upper Cretaceous Nanxiong Formation of Ganzhou City, Jiangxi Province. The new taxon differs from other oviraptorids in the weakly downturned rostrum of the lower jaw, much-elongated mandible with a height-to-length ratio being about 20% and the length ratio of radius to humerus of about 0.70. This species not only adds a new member to oviraptorid dinosaurs, but also provides more information about oviraptorid paleogeographical distribution in southern China. | WEI Xuefang PU Hanyong XU Li LIU Di Lü Junchang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 6 |
| 6 | Shape and position of Earth's bow shock near-lunar orbit based on ARTEMIS data显示文摘Earth's bow shock is the result of interaction between the supersonic solar wind and Earth's magnetopause. However, data limitations mean the model of the shape and position of the bow shock are based largely on near-Earth satellite data. The model of the bow shock in the distant magnetotail and other factors that affect the bow shock, such as the interplanetary magnetic field(IMF) B_y, remain unclear. Here, based on the bow shock crossings of ARTEMIS from January 2011 to January 2015, new coefficients of the tail-flaring angle a of the Chao model(one of the most accurate models currently available) were obtained by fitting data from the middle-distance magnetotail(near-lunar orbit, geocentric distance -20R_E>X>-50R_E). In addition, the effects of the IMF B_y on the flaring angle a were analyzed. Our results showed that:(1) the new fitting coefficients of the Chao model in the middle-distance magnetotail are more consistent with the observed results;(2) the tail-flaring angle a of the bow shock increases as the absolute value of the IMF B_y increases. Moreover, positive IMF B_y has a greater effect than negative IMF B_y on flaring angle. These results provide a reference for bow shock modeling that includes the IMF B_y. | LIU Ji SHI QuanQi TIAN AnMin Lü JianYong WU Hao WANG Ming FU SuiYan YANG YuChen ZONG QiuGang ZHANG Jiang FENG YongYong PU ZuYin | 2016 | Science China Earth Sciences2016，59，8： | 3 |
| 7 | A New Lizard(Lepidosauria:Squamata) from the Upper Cretaceous of Henan,China显示文摘Funiusaurus luanchuanensis gen.et sp.nov.was described on the basis of an incomplete skull from the Upper Cretaceous Qiupa Formation of the Tantou Basin in Luanchuan County,Henan Province.It is the second representative of lizards known from Luanchuan and adds a new member to the Luanchuan Fauna.F.luanchuanensis is a small-sized lizard and systematically assigned to the Polyglyphanodontidae of the Teiioidea because of the presence of a caniniform tooth and an elongate posterior process of the postorbital.It is distinctive in that the heterodont dentition bears 19 teeth in both the upper and lower jaws,the 3rd maxillary tooth is large and caniniform,the post-caniniform teeth in maxilla and those posterior to the 3rd dentary tooth are chisel-like in lateral view,the prefrontal possesses a fossa on its lateral surface,the postorbital with an extremely elongate posterior process and the well-developed retroarticular process has a deep fossa on its dorsal surface.In phylogeny,our analysis suggests a close relationship of Funiusaurus to the large-sized Tianyusaurus from the same basin within the Tuberocephalosaurinae.The discovery of Funiusaurus is significant in confirming the status of the Tuberocephalosaurinae,which includes a group of the Asian members of the Polyglyphanodontidae only. | XU Li WU Xiaochun Lü Junchang JIA Songhai ZHANG Jiming PU Hanyong ZHANG Xingliao | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 2 |
| 8 | Increased serum glycated albumin level is associated with the presence and severity ofcoronary artery disease in type 2 diabetic patients显示文摘 | PU L J LU L SHEN W F | 2007 | Circ J2007，71，7： | 1 |
| 9 | Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes显示文摘 | Pu LJ Lu L Xu XW | 2006 | Cardiovasc Diabetol2006，20，5： | 1 |
| 10 | Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chi nese population显示文摘 | Liang G Pu Y Yin L | 2005 | Cancer Lett2005，223，2： | 1 |
| 11 | The study of chiral conjugated pol-ymers 显示文摘 | Pu L | 1997 | Acta Polym1997，48，： | 1 |
| 12 | Serum advancedglycationendproducts and receptors as prognostic biomarkers indiabeticundergoingcoronaryarterystentimplantation显示文摘 | Shen Y Pu LJ Lu L etal | 2012 | CanJCardiol2012，28，6： | 1 |
| 13 | Freeze-drying of human red blood cells: influence of carbohydrates and their concentrations显示文摘 | Yu Jianping Liu J H Pu L Q Cui Xiangdong Wang Changzheng Ouyang S L Gao Dayong | 2004 | Cell Preservation Technology2004，2，4： | 1 |
| 14 | Challenges and opportunities of underwater cognitive acoustic networks 显示文摘 | Luo Y Pu L Zuba M | 2014 | 1EEE Trans- actions on Emerging Topics in Computing2014，2，2： | 1 |
| 15 | The in vivo role of p38MAP kinases in cardiac remodeling and restrictive cardiomyopathy显示文摘 | Pu L Dimitrios G Attila K | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 16 | α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose显示文摘 | Xiang G Pu J Yue L | 2011 | Metabolism2011，60，4： | 1 |
| 17 | Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes显示文摘 | Pu LJ Lu L Shen WF | 2006 | Cardiovasc Diabetol2006，5，： | 1 |
| 18 | Fractional differential mask:a fractional differential-based approach for multiscale texture enhancement显示文摘 | Pu Y F Zhou J L Yuan X | 2010 | IEEE Transactions on Image Processing2010，19，2： | 1 |
| 19 | Assessment of multi- resolution and multi-sensor data for urban surface temperature re- trieval显示文摘 | PU R L GONG P MICHISHITA R | 2006 | Remote Sensing of Environment2006，104，： | 1 |
| 20 | Association of serum levels of glycated albumin,C-reactive protein and tumor necrosis factor-α with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus显示文摘 | Lu L Pu LJ Xu XW | 2007 | Clinical Biochemistry2007，40，11： | 1 |
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