| 2 | Near carbon‑zero cycle from VOCs capture to carbon fixation显示文摘A new technical route of organic matter capture and carbon fixation is proposed in response of the increasingly strict emission standards of volatile organic compounds(VOCs)in petrochemical industry and the Chinese national strategic development goals of carbon peak and carbon neutralization.A closed loop from raw materials to adsorbents for gas treatment can be achieved by two key technical characteristics:(1)construct a new mesoporous adsorbent with complete desorption and regeneration function by carbon nanotubes(CNTs);(2)convert gaseous organic matter which cannot be recycled in liquid/gas state to CNTs.It realizes the resource integration of'turning waste into treasure'and maximizes the carbon emission reduction effect of waste gas treatment process without consuming extra precious fossil fuel,compared with the traditional technologies of VOCs treatments,including combustion or catalytic oxidation.What’s more,the increase in supply of various green electricity is expected to change the current situation of large investment and heavy cost burden of environmental protection technology,and make a great contribution to the national carbon peak and carbon neutrality policy. | Zefang Yin Chaojie Cui Xiang Yu Wanghua Zhao Dexi Lin Yu Zhang Kang Li Weizhong Qian | 2022 | Carbon Neutrality2022，1，1： | 0 |
| 3 | Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S显示文摘Background and Aims:Continuous release and transmission of hepatitis B virus(HBV)is one of the main factors leading to chronic hepatitis B(CHB)infection.However,the mechanism of HBV-host interaction for optimal viral transport is unclear.Hence,we aimed to explore how HBV manipulates microtubule-associated protein 1S(MAP1S)and microtubule(MT)to facilitate its transport and release.Methods:The expression of MAP1S or acetylated MT was investigated by immunofluorescence,RT-PCR,immunoblotting,and plasmid transfection.MAP1S overexpression or knockdown was performed by lentiviral infection or shRNA transfection,respectively.HBV DNA was quantified using q-PCR.Results:Significantly higher level of MAP1S in HepG2215 cells compared with HepG2 cells was detected using RT-PCR(p<0.01)and immunoblotting(p<0.001).Notably,stronger MAP1S expression was observed in the liver tissues of patients with CHB than in healthy controls.MAP1S overexpression or knockdown demonstrated that MAP1S promoted MT acetylation and reduced the ratio of HBV DNA copies inside to outside cells.Further,transfection with the hepatitis B virus X protein(HBx)-expressing plasmids induced significantly higher level of MAP1S than that in controls(p<0.0001),whereas HBVX−mutant-encoding HBV proteins(surface antigen,core protein,and viral DNA polymerase)hardly affected its expression.Conclusions:These results demonstrate that HBx induces the forma tion of stable MTs to promote the release of HBV particles through upregulating MAP1S.Thus,our studies delineate a unique molecular pathway through which HBV manipulates the cytoskeleton to facilitate its own transportation,and indicate the possibility of targeting MAP1S pathway for treatment of patients with CHB. | Yuanyue Guan Bin Sun Shijie Zhang Yuan Zhuang Yanxiang Huang Minghua Lin Rongling Zheng Dexi Chen Ying Shi Yanjun Wang | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 0 |
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