|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Folate-chitosan-gemcitabine core-shell nanoparticles targeted to pancreatic cancer显示文摘Objective:Human pancreatic cancer is one of the most common clinical malignancies.The effect of comprehensive treatment based on surgery is general.The effects of chemotherapy were not obvious mainly because of lack of targeting and chemoresistance in pancreatic cancer.This study aimed to investigate the effects of folate receptor(FR)-mediated gemcitabine FA-Chi-Gem nanoparticles with a core-shell structure by electrostatic spray on pancreatic cancer.Methods:In this study,the levels of expression of FR in six human pancreatic cancer cell lines were studied by immunohistochemical analysis.The uptake rate of isothiocyanate-labeled FA-Chi nanoparticles in FR high expression cell line COLO357 was assessed by fluorescence microscope and the inhibition rate of FAChi-Gem nanoparticles on COLO357 cells was evaluated by MTT assay.Moreover,the biodistribution of PEG-FA-ICGDER02-Chi in the orthotopic pancreatic tumor model was observed using near-infrared imaging and the human pancreatic cancer orthotopic xenografts were treated with different nanoparticles and normal saline control.Results:The expression of FR in COLO357 was the highest among the six pancreatic cancer cell lines.The FR mainly distributed on cell membrane and fewer in the cytoplasm in pancreatic cancer.Moreover,the absorption rate of the FA-Chi-Gem nanoparticles was more than the Chi nanoparticles without FA modified.The proliferation of COLO357 was significantly inhibited by FA-Chi-Gem nanoparticles.The PEG-FAICGDER02-Chi nanoparticles were enriched in tumor tissue in human pancreatic cancer xenografts,while non-targeted nanoparticles were mainly in normal liver tissue.PEG-FA-Gem-Chi significantly inhibited the growth of human pancreatic cancer xenografts(PEG-FA-Gem-Chi vs.Gem,t=22.950,P=0.000).Conclusions:PEG-FA-FITC-Chi nanoparticles might be an effective targeted drug for treating human FR-positive pancreatic cancer. | Jiahua Zhou Junying Wang Qian Xu Shi Xu Jin Wen Zeqian Yu Detong Yang | 2013 | Chinese Journal of Cancer Research2013，25，5： | 5 |
| 2 | NONMONOTONIC REDUCED PROJECTED HESSIAN METHOD VIA AN AFFINE SCALING INTERIOR MODIFIED GRADIENT PATH FOR BOUNDED-CONSTRAINED OPTIMIZATION显示文摘作者与减少的射影的麻袋布联合建议一个仿射的可伸缩的修改坡度路径方法;为解决线性平等的非单调的内部回溯线搜索技术在变量上抑制了优化题目到界限。由采用限制矩阵的 QR 分解;处于潜水艇问题的减少的射影的麻袋布矩阵的 eigensystem 分解,作者形成仿射的可伸缩的修改坡度曲线的路径很容易。由使用内部回溯的线搜索技术,各重申换到严格的内部可行性的试用步。全球集中;建议算法的快本地 superlinear/quadratical 集中率在一些合理条件下面被建立。一个非单调的标准应该引起在一些性恶的盒子中加快集中进步。数字实验的结果被报导显示出建议算法的有效性。 | Peihua GUO Detong ZHU | 2008 | Journal of Systems Science & Complexity2008，21，1： | 4 |
| 3 | A LINE SEARCH FILTER SECANT METHOD FOR NONLINEAR EQUALITY CONSTRAINED OPTIMIZATION显示文摘This paper formulates and analyzes a line search method for general nonlinear equalityconstrained optimization based on filter methods for step acceptance and secant methods for searchdirection.The feature of the new algorithm is that the secant algorithm is used to produce a searchdirection,a backtracking line search procedure is used to generate step size,some filtered rules areused to determine step acceptance,second order correction technique is used to reduce infeasibility andovercome the Maratos effect.Global convergence properties of this method are analyzed:under mildassumptions it is showed that every limit point of the sequence of iterates generated by the algorithmis feasible,and that there exists at least one limit point that is a stationary point for the problem.Moreover,it is also established that the Maratos effect can be overcome in our new approach by addingsecond order correction steps so that fast local superlinear convergence to a second order sufficient localsolution is achieved.Finally,the results of numerical experiments are reported to show the effectivenessof the line search filter secant method. | Zhujun WANG Detong ZHU | 2010 | Journal of Systems Science & Complexity2010，23，2： | 3 |
| 4 | Three-dimensional numerical modeling of nearshore circulation显示文摘A three-dimensional nearshore circulation model was developed by coupling CH3D, a three-dimensional hydrodynamic model and REF/DIF, a nearshore wave transformation model. The model solves the three-dimensional wave-averaged equations of motion. Wave-induced effects on circulation were introduced in the form of radiation stresses, wave-induced mass transport, wave-induced enhancement of bottom friction and wave-induced turbulent mixing. Effects of breaking waves were considered following Svendsen (1984a and 1984b) and Stive and Wind (1986). The model was successfully tested against the analytical solution of longshore currents by Longuet and Higgins (1970). The model successfully simulated the undertow as observed in a laboratory experiment by Stive and Wind (1982). In addition, the model was applied to a physical model by Mory and Hamm (1997) and successfully reproduced the eddy behind a detached breakwater as well as the longshore current on the open beach and the contiguous eddy in the open area of the wave tank. While the qualitative agreement between model results and experimental observations was very good, the quantitative agreement needs to be further improved. Albeit difficult to explain every discrepancy between the model results and observations, in general, sources of errors are attributed to the lack of understanding and comprehensive description of following processes: (1)the horizontal and vertical distribution of radiation stress, especially for breaking waves;(2)the detailed structure of turbulence;(3)Wave-current interaction (not included at this moment); and (4)the wave-current boundary layer and the resulting bottom shear stress. | SUN Detong | 2008 | Acta Oceanologica Sinica2008，27，z1： | 2 |
| 5 | A Dwindling Filter Line Search Algorithm for Nonlinear Equality Constrained Optimization显示文摘This paper proposes a dwindling filter line search algorithm for nonlinear equality constrained optimization. A dwindling filter, which is a modification of the traditional filter, is employed in the algorithm. The envelope of the dwindling filter becomes thinner and thinner as the step size approaches zero. This new algorithm has more flexibility for the acceptance of the trial step and requires less computational costs compared with traditional filter algorithm. The global and local convergence of the proposed algorithm are given under some reasonable conditions. The numerical experiments are reported to show the effectiveness of the dwindling filter algorithm. | GU Chao ZHU Detong | 2015 | Journal of Systems Science & Complexity2015，28，3： | 2 |
| 6 | A Dwindling Filter Algorithm with a Modified Subproblem for Nonlinear Inequality Constrained Optimization显示文摘The authors propose a dwindling filter algorithm with Zhou's modified subproblem for nonlinear inequality constrained optimization.The feasibility restoration phase,which is always used in the traditional filter method,is not needed.Under mild conditions,global convergence and local superlinear convergence rates are obtained.Numerical results demonstrate that the new algorithm is effective. | Chao GU Detong ZHU | 2014 | Chinese Annals of Mathematics,Series B2014，35，2： | 2 |
| 7 | CONVERGENCE PROPERTIES OF PROJECTED GRADIENT METHODS WITH NONMONOTONIC BACK TRACKING TECHNIQUE FOR CONVEX CONSTRAINED OPTIMIZATION显示文摘This paper proposes projected gradient algorithms in association with using both trust region and line search techniques for convex constrained optimization problems. The mixed strategy is adopted which switches to back tracking steps when a trial projected gradient step produced by the trust region subproblem is unacceptable. A nonmonotone criterion is used to speed up the convergence progress in some curves with large curvature. A theoretical analysis is given which proves that the proposed algorithms are globally convergent and have local superlinear convergence rate under some reasonable conditions. The results of numerical experiments are reported to show the effectiveness of the proposed algorithms. | ZHU Detong (Department of Mathematics, Shanghai Normal University, Shanghai 200234, China) | 2000 | Systems Science and Mathematical Sciences2000，13，4： | 2 |
| 8 | Marker Expression in Circulating Cancer Cells of Pancreatic Cancer Patients显示文摘 | Jiahua Zhou Liang Hu Zeqian Yu Jie Zheng Detong Yang Michael Bouvet Robert M. Hoffman | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 9 | Fault detec- tion of planetary gearboxes using new diagnostic pa rameters显示文摘 | Lei Yaguo Kong Detong Lin Jing | 2012 | Measurement Science and Technology2012，23，8： | 1 |
| 10 | A reduced Hessian algo- rithm with line search filter method for nonlinear programming显示文摘 | Wang Zhujun Zhu Detong | 2011 | Applied Mathematics and Compu- tation2011，217，19： | 1 |
| 11 | Fault detection of planetary gear boxes using new diagnostic parameters 显示文摘 | LEI Yaguo KONG Detong LIN Jing | 2012 | Measurement Science and Technolo- gy2012，23，5： | 1 |
| 12 | On Polynomiality of the Mehrotra-Type Predietor-Correetor Interior-Point Algorithms 显示文摘 | ZHANG Yin ZHANG Detong | 1995 | Math Program1995，68，123： | 1 |
| 13 | A filter interior-point algorithm with projected Hessian updating for nonlinear optimization显示文摘 | Chao Gu Detong Zhu | 2009 | Journal of Applied Mathematics and Computing (-)2009，，1： | 1 |
| 14 | Design and observations of satellite laser ranging system for daylight tracking at Shanghai Observatory显示文摘 | Fumin Yang Chikun Xiao Wanzhen Chen Zhongping Zhang Detong Tan Xiangdong Gong Juping Chen Huang Li Jianhua Zhang | 1999 | Science in China Series A: Mathematics1999，，2： | 1 |
| 15 | AN AFFINE SCALING DERIVATIVE-FREE TRUST REGION METHOD WITH INTERIOR BACKTRACKING TECHNIQUE FOR BOUNDED-CONSTRAINED NONLINEAR PROGRAMMING显示文摘This paper proposes an affine scaling derivative-free trust region method with interior backtracking technique for bounded-constrained nonlinear programming.This method is designed to get a stationary point for such a problem with polynomial interpolation models instead of the objective function in trust region subproblem.Combined with both trust region strategy and line search technique,at each iteration,the affine scaling derivative-free trust region subproblem generates a backtracking direction in order to obtain a new accepted interior feasible step.Global convergence and fast local convergence properties are established under some reasonable conditions.Some numerical results are also given to show the effectiveness of the proposed algorithm. | GAO Jing ZHU Detong | 2014 | Journal of Systems Science & Complexity2014，27，3： | 1 |
| 16 | Superlinear convergence of infeasible-interior-point methods for linear programming显示文摘 | Yin Zhang Detong Zhang | 1994 | Mathematical Programming (-)1994，，1： | 1 |
| 17 | A NONMONOTONE TRUST REGION TECHNIQUEFOR UNCONSTRAINED OPTIMIZAfIONPROBLEMS显示文摘Trust region methods with nonmonotone technique for unconstrained opti-mization problems are presented and analyzed. The convergence results are demonstratedfor the proposed algorithms even if the conditions are mild. | ZHU Detong(Department of Mathematics, Shanghai Normal University, Shanghai 200234 China) | 1998 | Systems Science and Mathematical Sciences1998，11，4： | 1 |
| 18 | Fault detection of planetary gearboxes using new diagnostic parameters显示文摘 | LEI Yaguo KONG Detong LIN Jing | 2012 | Measurement Science and Technology2012，23，5： | 1 |
| 19 | Affine scaling inexact generalized Newton algorithm with interior backtracking technique for solving bound-constrained semismooth equations显示文摘 | Zhu Detong | 2006 | J Comput Appl Math2006，187，： | 1 |
| 20 | Topoisomomerase Ⅱ as a target of VM- 26 and 4' - (9 - Acridinylamino) methanesulfonmaniside in atypical multidrug resistant human small cell lung carcinoma cells显示文摘 | Detong S Kooistra AT Devries E | 1993 | Cancer Res1993，53，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员