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| 1 | Multiple Chromatographic and Chemometric Methods for Quality Standardization of Chinese Herbal Medicines显示文摘Quality standardization of complementary medicine is fundamental for industry and practice as it underpins the quality,safety and efficacy of Chinese herbal medicines.Current herbal standardizations are often based on the quantitative analysis of a single compound,which may not reflect the total characteristic,bioactive and toxic nature of the herbs or products.Therefore,there is a need to establish an internationally recognized methodology for quality standardization of Chinese herbal medicines.The analytical methods reviewed in this article are pharmacognosy,TLC,HPLC,LCMS,CE and chemo-metrics.This article also covers the developments and applications of these methods in quality standardization.Recent advances show that a combination of these methods creates an overall chemical profile of each herb.This is supported by results reviewed in this article and obtained in our laboratory tests on medicinal herbs including Hypericum perforatum,Morinda officinalis and Centella asiatica.Significant variations in active components have been observed between herbal samples and products.It is proposed that the identification of active components,pharmacological activities and eventual clinical applications are required for a comprehensive quality standardization system.Our findings indicate that the combination of various chromatographic and chemometric methods will advance the methodology of quality standardization and enhance the overall confidence in herbal medicine for the health practitioner and the public. | Valentina Razmovski-Naumovski Wannit Tongkao-on Benjamin Kimble Vincent L. Qiao Bei-lun Lin Kong M. Li Basil Roufogalis Depo Yang Meicun Yao George Q. Li | 2010 | 世界科学技术-中医药现代化2010，12，1： | 5 |
| 2 | Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis显示文摘 | Depo Y Laura M Jean-Pierre Chaumont | 1999 | Mycopathologia1999，148，： | 1 |
| 3 | Impact of sewage sludge application on soil biological characteristics 显示文摘 | Banerjee M R Burton D L Depoe S | 1997 | Agric Ecosyst Environ1997，66，： | 1 |
| 4 | Activation of mi- croglial N-methyl-D-aspartate receptors triggers inflamma- tion and neuronal cell death in the developing and mature brain显示文摘 | Kaindl AM Depos V Peineau S | 2012 | Ann Neurol2012，72，4： | 1 |
| 5 | Impact of sewage sludge application on soil biological characteristics 显示文摘 | Banerjee M R Burton D L Depoe S | 1997 | Agri- culture Ecosystems and Environment1997，66，3： | 1 |
| 6 | The mechanism of hydrogen evolution reaction on a modified raney-nickel composite-coated electrode by AC impedance 显示文摘 | OKIDO M DEPO J K CAPUANO G A | 1993 | J Electrochem Soc1993，140，1： | 1 |
| 7 | Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines显示文摘 | Ellie J.Y. Kim Yuling Chen Johnson Q. Huang Kong M. Li Valentina Razmovski-Naumovski Josiah Poon Kelvin Chan Basil D. Roufogalis Andrew J. McLachlan Sui-Lin Mo Depo Yang Meicun Yao Zhaolan Liu Jianping Liu George Q. Li | 2013 | Journal of Ethnopharmacology2013，，1： | 1 |
| 8 | Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry 显示文摘 | LIN Shuhai WANG Dongmei YANG Depo | 2007 | Anal Chim Acta2007，599，： | 1 |
| 9 | Isolation and Purification of Isoquercitrin and Quercitrin from sf Hypericum Japonicum Thunb.ex Murray by Counter-Current Chromatography显示文摘 | Zhisheng Xie Jieyun Huang Zhiyong Xie Xiaoxue Yu Mei Yang Depo Yang Xinjun Xu | 2014 | Separation Science and Technology2014，，5： | 1 |
| 10 | Removal of three kinds of phthalates from sweet orange oil by molecular distillation显示文摘 | Ying Xiong Zhimin Zhao Longping Zhu Yunting Chen Hongbin Ji Depo Yang | 2013 | LWT - Food Science and Technology2013，，2： | 1 |
| 11 | Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry显示文摘 | LIN Shuhai WANG Dongmei YANG Depo | 2007 | Analytica Chimica Acta2007，599，1： | 1 |
| 12 | Impact of sewage sludge application on soil biological characteristics显示文摘 | BANERIEE M R BURTON D L DEPOE S | 1997 | Agriculture Ecosystems & Environment1997，66，3： | 1 |
| 13 | Impact of sewage sludge application on soil biological characteristics显示文摘 | Banerjee M R Burton D L Depoe S | 1997 | Agriculture Ecosystems and Environment1997，66，3： | 1 |
| 14 | Impact of sewage sludge application on soil biological characteristics显示文摘 | Banerjee M R Burton D L Depoe S | 1997 | Agriculture Ecosystems & Environment1997，66，3： | 1 |
| 15 | Chry- somya megaeephala (Fabricius) larvae:A new biodiesel resource显示文摘 | Li Zhuoxue Yang Depo Miaoling Huang | 2012 | Applied Energy2012，94，： | 1 |
| 16 | Biodiesel from zophobas morio larva oil: process optimization and FAME characterization 显示文摘 | Dong Leung Yang Depo Li Zhuoxue | 2012 | lndustrial and Engineering Chemistry Research2012，51，2： | 1 |
| 17 | Characterization of steroidal saponins in etude extract from dioseorea nipponiea Makino by liquid chromatography tandem multi stage mass spectrometry 显示文摘 | Shuhai Lin Dongmei Wang Depo Yang | 2007 | Analytiea Chimiea Aeta2007，7，7： | 1 |
| 18 | Impact of sewage sludge application on soil biological characteristics显示文摘 | Banerjee M R Burton D L Depoe S | 1997 | Agriculture Ecosystems and Environment1997，66，3： | 1 |
| 19 | Multiomics comparison among populations of three plant sources of Amomi Fructus显示文摘Amomi Fructus(Sharen,AF)is a traditional Chinese medicine(TCM)from three source species(or varieties),including Wurfbainia villosa var.villosa(WVV),W.villosa var.xanthioides(WVX),or W.longiligularis(WL).Among them,WVV has been transplanted from its top-geoherb region,Guangdong,to its current main production area,Yunnan,for>50 years in China.However,the genetic and transcriptomic differentiation among multiple AF source species(or varieties)and between the origin and transplanted populations of WVV is unknown.In our study,the observed overall higher expression of terpenoid biosynthesis genes in WVV than in WVX provided possible evidence for the better pharmacological effect of WVV.We also screened six candidate borneol dehydrogenases(BDHs)that potentially catalyzed borneol into camphor in WVV and functionally verified them.Highly expressed genes at the P2 stage of WVV,Wv05G1424 and Wv05G1438,were capable of catalyzing the formation of camphor from(+)-borneol,(-)-borneol and DL-isoborneol.Moreover,the BDH genes may experience independent evolution after acquiring the ancestral copies,and the following tandem duplications might account for the abundant camphor content in WVV.Furthermore,four populations of WVV,WVX,and WL are genetically differentiated,and the gene flow from WVX to WVV in Yunnan contributed to the greater genetic diversity in the introduced population(WVV-JH)than in its top-geoherb region(WVV-YC),which showed the lowest genetic diversity and might undergo genetic degradation.In addition,terpene synthesis(TPS)and BDH genes were selected among populations of multiple AF source species(or varieties)and between the top-and non-top-geoherb regions,which might explain the difference in metabolites between these populations.Our findings provide important guidance for the conservation,genetic improvement,and industrial development of the three source species(or varieties)and for identifying top-geoherbalism with molecular markers,and proper clinical application of AF. | Xinlian Chen Shichao Sun Xiaoxu Han Cheng Li Fengjiao Wang Bao Nie Zhuangwei Hou Song Yang Jiaojiao Ji Ge Li Yanqian Wang Xiaoyu Han Jianjun Yue Cui Li Wei Li Lixia Zhang Depo Yang Li Wang | 2023 | Horticulture Research2023，10，8： | 0 |
| 20 | Bornyl acetate extracted from Sharen(Fructus Amomi)inhibits proliferation,invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer显示文摘OBJECTIVE:To investigate the antitumor effects of bornyl acetate(BA)isolated from Sharen(Fructus Amomi)in colorectal cancer(CRC)and the underlying mechanisms.METHODS:SW480 and HT29 cells were treated with increasing doses of BA in order to determine its antitumor effects in vitro.Cell viability,colony formation,cell cycle,and apoptosis as well as migration and invasion were assessed using various assays.In addition,the in vivo antitumor effects of BA were assessed using a xenograft mouse model.We then assessed the mechanism of action of BA by conducting pathway activator-mediated rescue experiments and assessed the protein levels by Western blot analysis.RESULTS:BA showed anti-CRC tumor activities in vitro by suppressing cell proliferation and colony formation,inducing apoptosis,blocking cell cycle,and inhibiting migration and invasion.These effects were mediated via suppression of the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway.In the tumor xenograft experiment,BA was found to repress tumor growth in vivo with low toxicity.CONCLUSIONS:The results demonstrated that BA exerts antitumor effects by suppressing the PI3K/AKT pathway,with low toxicity.Thus,BA might be a potential novel therapeutic agent for CRC. | LI Xiaohua DUAN Zhihang YUE Jianjun ZHANG Yongyu LI Yihang LIU Shifang NIE Qu YANG Depo ZHANG Lixia | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
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