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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Pathophysiology of my cardial perfusion in hypertension显示文摘 | Harrison DG Marcus mL Dellsperger KC | 1991 | Circulation1991，83，： | 1 |
| 3 | Cardiorenal syndrome: the clinical cardiologists' perspective显示文摘 | Chan EJ Dellsperger KC | 2011 | Cardiorenal Med2011，1，1： | 1 |
| 4 | Update on cardiorenal syndrome: a clinical conundrum 显示文摘 | Chan EJ Dellsperger NC | 2011 | Adv Petit Dial2011，27，： | 1 |
| 5 | Educational quality improvement report:outcomes from a revised morbidity and mortality format that emphasised patient safety显示文摘 | Bechtold ML Scott S Dellsperger KC | 2008 | Postgrad Med J2008，84，990： | 1 |
| 6 | Impaired microvascular responseto graded coronary occlusion in diabetic and hyperglycemic dogs 显示文摘 | Kersten JR Brooks LA Dellsperger KC | 1995 | Am J Physiol1995，268，42： | 1 |
| 7 | Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor 显示文摘 | Harlan SM Morgan DA Dellsperger D J | 2011 | Hypertension2011，57，3： | 1 |
| 8 | Cardiovascular issues in dialysis patients:challenges and newer insights显示文摘 | Guzon OJ Dellsperger KC | 2006 | Adv Petit Dial2006，22，3： | 1 |
| 9 | New polyamide with long alkane segments: nylon 6 24 and 6 34 显示文摘 | Ehrenstein M Dellsperger S Kocher C | 2000 | Polymer2000，41，： | 1 |
| 10 | EET homologs potently dilate coronary microvessels and activate large conductance Ca2 + -activated potassium channels显示文摘 | Zhang Y Ottman CL Lu T Lee HC Dellsperger KC VanRollins M | 2001 | Am J Physiol Heart Circ Physiol2001，280，： | 1 |
| 11 | The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update显示文摘 | Zhang H Dellsperger KC Zhang C | 2012 | Basic Res Cardiol2012，107，： | 1 |
| 12 | Cardiorenal syndrome: the clinical cardiologists' perspective 显示文摘 | Chan EJ Dellsperger KC | 2011 | Cardiorenal Med2011，1，1： | 1 |
| 13 | Cardiovascular issues in dialysis patients:challenges and newer insights显示文摘 | Guzon OJ Dellsperger KC | 2006 | Adv Perit Dia2006，22，： | 1 |
| 14 | 显示文摘 | Dellsperger S Dotz E Smith E | 2000 | Macromol Chem Phys2000，201，： | 1 |
| 15 | The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update显示文摘 | Zhang H Dellsperger KC Zhang C | 2012 | Basic Res Cardiol2012，107，1： | 1 |
| 16 | EET homologs potently dilate coronary microves sels and activate BKca channels显示文摘 | Zhang Y Oltman C L Lu T Lee H C Dellsperger K C Van- Rollins M | 2001 | Am J Physiol Heart Circ Physiol2001，280，： | 1 |
| 17 | Cardiovascular issues in dialysis patients: challenges and newer insights显示文摘 | Guzon OJ Dellsperger KC | 2006 | Adv Perit Dia2006，22，： | 1 |
| 18 | Simvastatin impairs exercise training adaptations显示文摘 | Catherine R. Mikus Leryn J. Boyle Sarah J. Borengasser Douglas J. Oberlin Scott P. Naples Justin Fletcher Grace M. Meers Meghan Ruebel M. Harold Laughlin Kevin C. Dellsperger Paul J. Fadel John P. Thyfault | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 19 | Dyslipidemia in patients with chronic and end-stage kidney disease显示文摘 | Omran J Al-Dadah A Dellsperger KC | 2013 | Cardiorenal Med2013，3，3： | 1 |
| 20 | Cardiovascular issues in dialysis patients: challenges and newer insights 显示文摘 | Guzon O J Dellsperger KC | 2006 | Adv Petit Dial2006，22，3： | 1 |
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