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| 1 | Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis显示文摘AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders. | Edith Lahner Enzo Grossi Marco Intraligi Massimo Buscema Vito D Corleto Gianfranco Delle Fave Bruno Annibale | 2005 | World Journal of Gastroenterology2005，11，37： | 4 |
| 2 | Type I Gastric Carcinoids: A Prospective Study on Endoscopic Management and Recurrence Rate显示文摘 | Merola Elettra Sbrozzi-vanni Andrea Panzuto Francesco D’ambra Giancarlo Di Giulio Emilio Pilozzi Emanuela Capurso Gabriele Lahner Edith Bordi Cesare Annibale Bruno Delle Fave Gianfranco | 2012 | Neuroendocrinology2012，，3： | 2 |
| 3 | Cardiovascular magnetic resonance in myocardial infarction with non-obstructive coronary arteries patients: A review显示文摘The diagnosis of myocardial infarction with non-obstructive coronary arteries(MINOCA)necessitates documentation of an acute myocardial infarction(AMI),non-obstructive coronary arteries,using invasive coronary angiography or coronary computed tomography angiography and no clinically overt cause for AMI.Historically patients with MINOCA represent a clinical dilemma with subsequent uncertain clinical management.Differential diagnosis is crucial to choose the best therapeutic option for ischemic and non-ischemic MINOCA patients.Cardiovascular magnetic resonance(CMR)is able to analyze cardiac structure and function simultaneously and provides tissue characterization.Moreover,CMR could identify the cause of MINOCA in nearly two-third of patients providing valuable information for clinical decision making.Finally,it allows stratification of patients with worse outcomes which resulted in therapeutic changes in almost half of the patients.In this review we discuss the features of CMR in MINOCA;from exam protocols to imaging findings. | Marco Gatti Andrea Carisio Tommaso D’Angelo Fatemeh Darvizeh Serena Dell’Aversana Davide Tore Maurizio Centonze Riccardo Faletti | 2020 | World Journal of Cardiology2020，12，6： | 2 |
| 4 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 5 | 无心血管病者尿钠排泄、血压与未来心血管病及死亡风险显示文摘高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄56.3岁,44.7%为男性)尿电解质与血压的数据。采用Kawasaki公式估算每日尿钠排泄量。研究者分析基线无心血管病、治疗的高血压或糖尿病者(n=322624)钠排泄与血压的关系,并评估钠排泄与致死性及非致死性心血管病、心力衰竭及死亡发生率的关系。 | Welsh CE Welsh P Jhund P Delles C Celis-Morales C Lewsey JD Gray S Lyall D Iliodromiti S Gill JMR Sattar N Mark PB 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 6 | Human erythropoietin induces a por-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo显示文摘 | Ribatti D Presta M Vacca A Ria A Giuliani R Dell'Era P | 1999 | Blood1999，93，： | 1 |
| 7 | Climate change and the effect of increasing spring temperatures on emergence dates of the butterfly Apatura iris (Lepidoptera: Nymphalidae)显示文摘 | Dell D Sparks T H Dennis R L H | 2005 | European Journal of Entomology2005，102，2： | 1 |
| 8 | Effects of phosphorus application on productivity and nutrient accumulation of a Eucalyptus urophylla plantation显示文摘 | Dell B Yang Z | 2005 | Journal of Tropical Forest Science2005，17，3： | 1 |
| 9 | Poly (silsesquioxanes) derived from the hydrolytic condensation of organotrialkoxysilanes containing hydroxyl groups显示文摘 | DELL ERBA I E FASCE D P WILLIAMS R J J | 2003 | J Organomet Chem2003，686，： | 1 |
| 10 | Early gastric cancer:prognostic factors in 223 Patients显示文摘 | Follis S Dente M Dell Amori D | 1995 | Br J surg1995，82，： | 1 |
| 11 | Prediction of fetal anemia with Doppler measurement of the middle cerebral artery peak systolic velocity in pregnancies complicated by maternal blood group alloimmunization or parvovirus B19 infection显示文摘 | Delle Chiaie L Buck G Grab D | 2001 | Ultrasound Obstet Gynecol2001，18，3： | 1 |
| 12 | Syndication in venture capital financing显示文摘 | DELl D N SANTHANAKRISHNAN M | 2010 | Financial Review2010，45，3： | 1 |
| 13 | On modularity clustering显示文摘 | Brandes U Delling D | 2008 | IEEE Transaction on Knowledge and Data Engineering2008，20，2： | 1 |
| 14 | In-nate nuclear sensor IFI16 translocates into the cyto- plasm during the early stage of in vitro human cyto- megalovirus infection and is entrapped in the egressing virions during the late stage显示文摘 | DELL'OSTE V GATTI D GUGLIESI F | 2014 | J Virol2014，88，： | 1 |
| 15 | The execution of the transcriptional axismutant p53, E2F1 and ID4 promotes tumor neo -angiogenesis显示文摘 | Fontemaggi G Dell Orso S Trisciuoglio D | 2009 | Nat Struet Mol Biol2009，6，10： | 1 |
| 16 | ARHGEF3 controls HDACi-induced differentiation via Rho A-dependent pathw ays in acute myeloid leukemias显示文摘 | D'Amato L Dell'Aversana C Conte M | 2015 | Epigenetics2015，10，1： | 1 |
| 17 | Time-dependent SHARC-routing 显示文摘 | Delling D | 2011 | Journal Algorithmica2011，60，1： | 1 |
| 18 | Molecules in focus: insulin-like growth factor Ⅱ 显示文摘 | O'Dell S D Day I N M | 1998 | International Journal of Biochemistry and Cell Biology1998，30，： | 1 |
| 19 | Evaluation of a stereo vision sensor system for the control of an autonomous guided vehicle显示文摘 | B F Buxton D A Castelow M J Dell | 1993 | SPIE1993，，1989： | 1 |
| 20 | Orientation in cognitive maps显示文摘 | HINTZMAN D O'DELL C ARNDT D | 1981 | Psychology1981，13，2： | 1 |
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