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| 1 | Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer:EGFR and beyond显示文摘Commonly observed aberrations in epidermal growth factor receptor(EGFR) signaling have led to the development of EGFR-targeted therapies for various cancers,including non-small cell lung cancer(NSCLC).EGFR mutations and overexpression have further been shown to modulate sensitivity to these EGFR-targeted therapies in NSCLC and several other types of cancers.However,it is clear that mutations and/or genetic variations in EGFR alone cannot explain all of the variability in the responses of patients with NSCLC to EGFR-targeted therapies.For instance,in addition to EGFR genotype,genetic variations in other members of the signaling pathway downstream of EGFR or variations in parallel receptor tyrosine kinase(RTK) pathways are now recognized to have a significant impact on the efficacy of certain EGFR-targeted therapies.In this review,we highlight the mutations and genetic variations in such genes downstream of EGFR and in parallel RTK pathways.Specifically,the directional effects of these pharmacogenetic factors are discussed with a focus on two commonly prescribed EGFR inhibitors:cetuximab and erlotinib.The results of this comprehensive review can be used to optimize the treatment of NSCLC with EGFR inhibitors.Furthermore,they may provide the rationale for the design of subsequent combination therapies that involve the inhibition of EGFR. | Christopher Delaney Samuel Frank R Stephanie Huang | 2015 | Chinese Journal of Cancer2015，34，4： | 6 |
| 2 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 3 | Comparison of in vivo and in vitro efficacy of ceftizoxime 显示文摘 | Delaney M L Cisneros R L | 1990 | Clin Ther1990，12，： | 2 |
| 4 | Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1显示文摘 | Mavrodi D V Bonsall R F Delaney S M | 2001 | J Bacteriol2001，183，： | 1 |
| 5 | Seasonal cycles of manganese and cadrnium in coral from the Galapagos Islands显示文摘 | DELANEY M L LINN L J DRUFFEL R M | 1993 | Geochimica et Cosmochimica Acta1993，57，： | 1 |
| 6 | Analysis and interpretation of the continuous hourly monitoring data for 26 C2- C8 hydrocarbons at 12 United Kingdom sites during 1996 显示文摘 | Derwent R G Davies T J Delaney M | 2000 | Atmospheric Environment2000，34，2： | 1 |
| 7 | PhzO,a gene for biosynthesis of 2-hydroxylated phenazine compounds in Pseudomonas aureofaciens 30-84显示文摘 | Delaney S M Mavrodi D V Bonsall R F | 2001 | J Bacteriol2001，183，1： | 1 |
| 8 | Standardized algorithms for management of anastomotic leaks and related abdominal and pelvic abscesses after colorectal surgery显示文摘 | Phitayakorn R Delaney CP Reynolds HL | 2008 | World J Surg2008，32，6： | 1 |
| 9 | Beta-glucan fractions from barley andoats are similarly antiatherogenicin hypercholesterolemic Syrian golden hamsters 显示文摘 | Delaney B Nicolosi R J Wilson T A | 2003 | Journal of Nutrition2003，，133： | 1 |
| 10 | Do all non-calcified echogenic renal lesions found on ultrasound need further evaluation with CT? 显示文摘 | Farrelly C Delaney H Mcdermott R | 2008 | Abdom Imaging2008，33，： | 1 |
| 11 | An Architecture for Semi-Automated Radar Image Exploitation显示文摘 | Keith Sisterson L John R Delaney Samuel J Gravina | 1998 | Lincoln Lab1998，11，2： | 1 |
| 12 | Volcanoes,fluids,and life at Mid-Ocean Ridge spreading centers显示文摘 | Kelley D S Baross J A Delaney J R | | 0，，01： | 1 |
| 13 | Next-generation tag sequencing for cancer gene expression profiling 显示文摘 | Morrissy A S Morin R D Delaney A | 2009 | Genome Research2009，19，： | 1 |
| 14 | Predictors of local recurrence after treatment of ductal carcinomain situ:a meta-analysis cancer显示文摘 | Boyages J Delaney G Taylor R | 1999 | 85(3):616-6281999，85，3： | 1 |
| 15 | Incidence and diversity of microorganisms within the walls of an active deep-sea sulfide chimney显示文摘 | Schrenk M O Kelley D S Delaney J R | | 0，，06： | 1 |
| 16 | Functional analysis of genes for biosynthesis of pyocyanin and phenazine212 carboxamide from Pseudomonas aeruginosa PAO11 显示文摘 | Mavrodi D V Bonsall R F Delaney S M | 2001 | J Bacteriol2001，183，64： | 1 |
| 17 | Blueprint for development ofthe advanced practice psychiatric nurse workforce 显示文摘 | Hanrahan N P Delaney K R Stuart G W | 2012 | Nurs Outlook2012，60，2： | 1 |
| 18 | Arabidopsis mutants simulating disease resistance response显示文摘 | Dietrich R A Delaney T P Uknes S J | 1994 | Cell1994，77，4： | 1 |
| 19 | Development of equations for predicting Puerto Rican subtropical dry forest biomass and volume显示文摘 | THOMAS J BRANDEIS MATTHEW DELANEY BER- NARD R PARRESOL | 2006 | Forest Ecology and Management2006，，233： | 1 |
| 20 | Arabidopsis mutants simulating disease resistance response显示文摘 | DIETRICH R A DELANEY T P | | 0，，04： | 1 |
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