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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | 羊膜移植治疗睑球黏连的临床观察(英文)显示文摘目的:评估羊膜移植(AMT)在治疗睑球黏连中的应用效果。方法:这项无对照干预性病例研究于2013/01~2015/12,包括连续就诊的12名患者共14眼。患者均接受永久性羊膜移植,以治疗睑球黏连,使用冷冻保存或冷冻干燥的羊膜(AM)。这12例(14眼)患者,年龄在26~62岁,平均43.38±11.25岁,其中8例(4名男性,4名女性)10眼为翼状胬肉切除术后继发,4例患者(1名男性,3名女性)斜视手术后继发。所有患者距上次手术至少6mo。术后以恢复深度稳定的穹窿为手术成功,无瘢痕或炎症发生,6mo的随访期间无眼球运动的限制。结果:随访期平均为7±4.2mo(6-9mo)。在所有14只眼中,手术后3wk均观察到AM完全上皮化,手术部位无炎症表现。总共14眼中有8眼(成功率57%)显示穹窿重建成功,穹窿深,无复发。有4眼(29%)表现出部分成功,中度深度的穹窿和中度瘢痕。有2眼(14%)显示重建失败,穹窿完全闭合。有7眼手术后视力改善,7眼视力保持稳定。AMT术后并发症少,14眼中1眼(7%)发生严重的结膜反应和眼球运动受限。而在术后前3mo中,14眼中有2眼发生化脓性肉芽肿(14%),予以手术切除,局部糖皮质激素注射。结论:单用AMT是一种治疗睑球黏连安全有效的方法。考虑到与角膜缘切除有关的潜在不良反应,AMT也是一种有效的重建穹窿以修复各种眼表疾病所致睑球黏连的方法。 | Ahmed Tamer Sayed Saif Passant Sayed Saif Amr El Deeb | 2017 | 国际眼科杂志2017，17，5： | 4 |
| 3 | Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis显示文摘 | Laurent Dubuquoy Emmelie ? Jansson Samir Deeb Sabine Rakotobe Mehdi Karoui Jean-Frédéric Colombel Johan Auwerx Sven Pettersson Pierre Desreumaux | 2003 | Gastroenterology2003，，5： | 2 |
| 4 | A Prol2Ala substitation in PPARg2 associated with decreased receptor activity lower body mass index and improved insulin sensitivity 显示文摘 | Deeb SS Fajas L Nemoto M | 1998 | Nat Gonet1998，20，： | 2 |
| 5 | Open arch reconstruction in the endovascular era: Analysis of 721 patients over 17 years显示文摘 | Himanshu J. Patel Christopher Nguyen Amy C. Diener Mary C. Passow Diane Salata G. Michael Deeb | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，6： | 2 |
| 6 | Structure of the human lipoprotein lipase gene显示文摘 | Deeb S S Peng R | 1989 | Biochemistry1989，28，： | 1 |
| 7 | Corrosion of tin in citric acid solution and the effect of some inorganic anions显示文摘 | Abdel Rehim S S Sayyah S M El Deeb M M | 2003 | Materials Chemistry and Physics2003，80，3： | 1 |
| 8 | H(Φ) spaces显示文摘 | DEEB W M MARZUQ M | 1986 | Can Math Bull1986，29，3： | 1 |
| 9 | Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry 显示文摘 | Deeb G Wang J Ramnath N | 2004 | Mod Pathol2004，17，4： | 1 |
| 10 | Chicken quantitative trait loci for growth and body composition associated with transforming growth factor-beta genes显示文摘 | Li H Deeb N Zhou H | 2003 | Poult Sci2003，82，3： | 1 |
| 11 | Linear reactive power optimization in a large power network using the decomposition approach显示文摘 | Deeb N Shahidepour S M | 1990 | IEEE Trans on Power Systems1990，5，2： | 1 |
| 12 | Curcumin (diferuloyl methane) enhances tumor necrosis factor-related apoptosis inducing lig- and-induced apoptosis in LNCaP prostate cancer cells显示文摘 | Deeb D Xu YX Jiang H | 2003 | Mol Cancer Ther2003，2，1： | 1 |
| 13 | Outcome of the dy- namic helical hip screw system for intertrochanterie hip fractures in the elderly patients 显示文摘 | O'Malley NT Deeb AP Bingham KW | 2012 | Geriatr Orthop Surg Rehabil2012，3，2： | 1 |
| 14 | Effects of a yoga intervention on lipid profiles of diabetes patientswith dyslipidemia显示文摘 | Shantakumari N Sequeira S E1 deeb R | 2013 | Indian Heart J2013，65，2： | 1 |
| 15 | Waist-to-Hip Ratio, Body Mass Index, and Subsequent Kidney Disease and Death显示文摘 | Essam F. Elsayed Mark J. Sarnak Hocine Tighiouart John L. Griffith Tobias Kurth Deeb N. Salem Andrew S. Levey Daniel E. Weiner | 2008 | American Journal of Kidney Diseases2008，，1： | 1 |
| 16 | Pattern of injury and the role of neutrophils in reperfusion injury of rat lung显示文摘 | Eppinger MJ Jones ML Deeb GM | 1995 | J Surg Res1995，58，6： | 1 |
| 17 | Angioedema associated with angiotensin Ⅱ receptor antagonists:challenging our knowledge of angioedema and its etiology显示文摘 | Chiu AG Krowiak EJ Deeb ZE | 2001 | Laryngoscope2001，111，： | 1 |
| 18 | Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype显示文摘 | Hernandez-Ilizaliturri FJ Deeb G Zinzani PL | | 0，，22： | 1 |
| 19 | Pattern of injury and the role of neutrophils in reperfusion injury of rat lung显示文摘 | Eppinger M J Jones ML Deeb GM | | 0，，06： | 1 |
| 20 | Vitamin D signalling pathways in cancer: potential for anticancertherapeutics 显示文摘 | Deeb KK Trump DL Johnson CS | 2007 | Nat Rev Cancer2007，7，9： | 1 |
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