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| 1 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
| 2 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 3 | H^+,N^+和Ar^+离子束辐射诱导碳纳米结构的变化(英文)显示文摘在室温和高温下,以不同辐射剂量的H+、N+和Ar+离子辐照多壁碳纳米管和无定形碳纳米线。利用透射电镜和拉曼光谱研究多壁碳纳米管和无定形碳纳米线的结构变化及损伤。以70keV N+离子束辐射多壁碳纳米管在室温下可形成无定形碳纳米线。1000K下70keV的H+离子束照射导致无定形碳纳米线向金刚石结构转变。离子辐照多壁碳纳米管的有序程度足够高,70keV的N+和Ar+离子能够引起碳从多壁碳纳米管的剥落。离子辐射能够为缺陷的转化提供必需的动力学驱动力。 | A Ishaq Shahid Iqbal Naveed Ali A A Khurram A U Akrajas C F Dee Shahzad Naseem H M Rafique Yan Long | 2013 | 新型炭材料2013，28，2： | 2 |
| 4 | Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression显示文摘AIM: To understand the role of mitochondrial-produced superoxide(O 2 ?) in the regulation of iron-regulatory hormone, hepcidin by alcohol in the liver. METHODS: For alcohol experiments, manganese superoxide dismutase knockout mice heterozygous for Sod2 gene expression(Sod2 +/) and age-matched littermate control mice(LMC), expressing Sod2 gene on both alleles, were exposed to either 10%(w/v) ethanol in the drinking water or plain water(control) for 7 d. Total cellular O 2 ? levels in hepatocytes isolated from the livers of mice were measured by electron paramagnetic resonance spectroscopy. The mitochondrial-targeted, O 2 ?-sensitive fluorogenic probe, MitoSOX Red and flow cytometry were utilized to measure O 2 ? in mitochondria. Gene and protein expression were determined by Taqman Real-time quantitative PCR and Western blotting, respectively. RESULTS: Sod2 +/- mice expressed 40% less MnSOD protein(SOD2) in hepatocytes compared to LMC mice. The deletion of Sod2 allele did not alter the basal expression level of hepcidin in the liver. 10% ethanol exposure for 1 wk inhibited hepatic hepcidin mRNA expression three-fold both in Sod2 +/ and LMC mice. O 2 ? levels in hepatocytes of untreated Sod2 +/ mice were three-fold higher than in untreated LMC mice, as observed by electron paramagnetic resonance spectroscopy. O 2 ? levels in mitochondria of Sod2 +/ mice were four-fold higher than in mitochondria of untreated LMC mice, as measured by MitoSOX Red fluorescence and flow cytometry. Alcohol induced a two-fold higher increase in O 2 ? levels in hepatocytes of LMC mice than in Sod2 +/ mice compared to respective untreated counterparts. In contrast, 1 wk alcohol exposure did not alter mitochondrial O 2 ? levels in both Sod2 +/- and control mice. CONCLUSION: Mitochondrial O2 ? is not involved in the inhibition of liver hepcidin transcription and thereby regulation of iron metabolism by alcohol. These findings also suggest that short-term alcohol consumption significantly elevates O 2 ? levels in hepatocytes, which appears not to originate from mitochondria. | Duygu Dee Harrison-Findik Sizhao Lu Emily M Zmijewski Jocelyn Jones Matthew C Zimmerman | 2013 | World Journal of Biological Chemistry2013，4，4： | 2 |
| 5 | Effect of vaccination with a modified-live porcine reproductive and respiratory syndrome virus vaccine on dynamics of homologous viral infection in pigs显示文摘 | Cano J P Dee S A Murtaugh M P | 2007 | Am J Vet Res2007，68，： | 1 |
| 6 | Effect of mono-ethyl-hexyl phthalate on MA-10 leydig tumor cells显示文摘 | DEES JH GZAOULI M PAPADOPOULOS V | 2001 | Reprod Toxicol2001，15，2： | 1 |
| 7 | Predictors of complications after endoscopic retrograde cholangiopancreatography: a prognostic model for early discharge显示文摘 | Jeurnink S M Siersema P D Steyerberg E W Dees J Poley J W Haringsma J | 2011 | Surg Endosc2011，25，： | 1 |
| 8 | The use of sulfated polyanions to prevent cell aggregation and enhance recombinant protein production显示文摘 | Dee K U Shuler M L Wood H A Inducing singlecell suspension ofBTI-TN5B1-4insect cells:I | 1997 | Biotechnol Bioeng1997，54，3： | 1 |
| 9 | Microbial diversit y in hot synthetic compost as revealed by PCR-Amplified rRNA sequences from cultivated isolates and extracted DNA显示文摘 | Peter M Dees P M Ghiorse W C | 2001 | FEMS Microbiology Ecology2001，35，2： | 1 |
| 10 | Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells 显示文摘 | Dees JH Gazouli M Papadopoulos V | 2001 | Reproductive Toxicology2001，，： | 1 |
| 11 | Effect of mono-ethylhexyl phthalate on MA-10 Leydig tumor cells显示文摘 | Dees J H Gazouli M Papadopoulos V | 2001 | Reprod Toxicol2001，15，2： | 1 |
| 12 | The ERA - Interim reanalysis: configuration and performance of the data assimilation system显示文摘 | Dee D P Uppala S M Simmons A J | 2011 | Q J R Meteorol Soc2011，137，： | 1 |
| 13 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
| 14 | Mirobial diversity in hot synthetic compost as revealed by PCR-amplified rRNA sequences from cultivated isolates and extracted DNA显示文摘 | DEES P M GHIORSE W C | 2001 | FEMS Microbiol Eco2001，35，： | 1 |
| 15 | Effect ofmonoethlhexyl phthalate on MA-10 Leydig tumor cells 显示文摘 | Dees J H Gazouil M Papadopoulos V | 2001 | Repord Toxicol2001，15，2： | 1 |
| 16 | Exploring the international linkages of the euro area:A global VAR analysis显示文摘 | DEES S MAURO F D PESARAN M H | 2007 | Journal of applied econometrics2007，22，1： | 1 |
| 17 | Transmission of PRRS virus from persistently infected sows to contact controls显示文摘 | Bierk M D Dee S A Rossow K D | 2001 | Can J Vet Res2001，65，4： | 1 |
| 18 | Microbial diversity in hot synthetic compost as revealed by PCR amplified rRNA sequences from cultivated isolates and extracted DNA 显示文摘 | Peter M Dees William C Ghiorse | 2001 | FEMS Microbiology Ecology2001，35，2： | 1 |
| 19 | The ERA-Interim reanalysis: Configuration and performance of the data assimilation system 显示文摘 | DEE D P UPPALA S M SIMMONS A J | 2011 | Q J R Meteo Soc2011，137，656： | 1 |
| 20 | Identification of genetically diverse sequences (ORF 5) of porcine reproductive and respiratory syndrome virus in a swine herd显示文摘 | Dee S A Torremorell M Rossow K | 2001 | Can J Vet Res2001，65，4： | 1 |
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