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68篇 您的检索式:作者名="Dees P M"
    题名 作者 年代 出处 被引量
1Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients.Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor 2016World Journal of Hypertension2016,6,1:3
2Effect of vaccination with a modified-live porcine reproductive and respiratory syndrome virus vaccine on dynamics of homologous viral infection in pigs显示文摘Cano J P Dee S A Murtaugh M P 2007Am J Vet Res2007,68,:1
3Predictors of complications after endoscopic retrograde cholangiopancreatography: a prognostic model for early discharge显示文摘Jeurnink S M Siersema P D Steyerberg E W Dees J Poley J W Haringsma J 2011Surg Endosc2011,25,:1
4Microbial diversit y in hot synthetic compost as revealed by PCR-Amplified rRNA sequences from cultivated isolates and extracted DNA显示文摘Peter M Dees P M Ghiorse W C 2001FEMS Microbiology Ecology2001,35,2:1
5The ERA - Interim reanalysis: configuration and performance of the data assimilation system显示文摘Dee D P Uppala S M Simmons A J 2011Q J R Meteorol Soc2011,137,:1
6Mirobial diversity in hot synthetic compost as revealed by PCR-amplified rRNA sequences from cultivated isolates and extracted DNA显示文摘DEES P M GHIORSE W C 2001FEMS Microbiol Eco2001,35,:1
7The ERA-Interim reanalysis: Configuration and performance of the data assimilation system 显示文摘DEE D P UPPALA S M SIMMONS A J 2011Q J R Meteo Soc2011,137,656:1
8Microbial diversity in hot synthetic compost as revealed by PCRamplified rRNA sequences from cultivated isolates and extracted DNA 显示文摘Dees P M Ghiorse W C 2001FEMS Microbiol Eco2001,35,:1
9Infection dynamics and clin- ical manifestations following experimental inoculation of gilts at 90 days of gestation with a low dose of porcine reproductive and respiratory syndrome virus显示文摘Cano J P Dee S A Murtaugh M P 2009Can J Vet Res2009,73,4:1
10Development of a high-power lithium-ion battery显示文摘JANSEN A N KAHAIAN A J KEPLER K D NELSON P A AMINE K DEES D W VISSERS D R THACKERAY M M 1999Journal of Power Sources1999,8182,:1
11The ERA-Interim reanalysis:configuration and performance of the data assimilation system显示文摘Dee D P Uppala S M Simmons A J 2011Quarterly Journal of the Royal Meteorological Society2011,137,656:1
12Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein显示文摘Spencer K A Dee M Britton P 2008Virology2008,370,2:1
13Epidemiological study of air filtration systems for preventing PRRSV infection in large sow herds显示文摘Alonso C Murtaugh M P Dee S A 2013Preventive Veterinary Medicine2013,112,1:1
14The ERA-Interim reanalysis: configuration and performance of the data assimilation system显示文摘DEE D P UPPALA S M SIMMONS A J 2011Quarterly Journal of the Royal Meteorological Society2011,137,1:1
15Fluoroscopic and computed tomographic features of the pharyngeal airway in obstructive sleep apnea显示文摘Suratt P M Dee P Atkinson R L 1983Am Rev Respir Dis1983,127,4:1
16Effect of vaccination with a modified-live porcine reproductive and respiratory syndrome virus vaccine on dynamics of homol- ogous viral infection in pigs 显示文摘CANO J P DEE S A MURTAUGH M P 2007American Journal Vet- erinary Research2007,68,5:1
17Development of a high-power lithium-ion battery显示文摘JANSEN A N KAHAIAN A J KEPLER K D NELSON P A AMINE K DEES D W VISSERS D R THACKERAY M M 1999Journal of Power Sources1999,8182,:1
18Microbial diversity in hot syntheticcompost revealed by PCR-amplified rRNA sequences fromcultivated isolates and extracted DNA 显示文摘Dees P M Ghiorse W C 2001Microbiology Ecology2001,35,2:1
19Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate 显示文摘CANO J P DEE S A MURTAUGH M P 2007Vaccine2007,25,:1
20A study of the hydrodynamics of female urethral experiments with models 显示文摘Scott J E S Clagton C B Dee P M 1986J Urol1986,96,:1
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