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| 1 | Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp.HB-J378显示文摘Marine natural products have become an increasingly important source of new drug leads during recent years.In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis sp.strain HB-J378.Notably,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these angucyclines.The structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS data.Nocardiopsistins A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,chloramphenicol.Bioinformatic analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins. | Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining Zhu Peter J.McCarthy Amy E.Wright Guojun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 3 |
| 2 | Chronic fatigue syndrome: a review显示文摘 | Niloofar Afari Dedra Buchwald | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 3 | Chronic fatigue syndrome: a review显示文摘 | Niloofar Marl Dedra Buchwald | 2003 | Am J Psychiatry2003，，160： | 1 |
| 4 | Fetal cardiomyopathies pathogenic mechanisms, hemodynamic findings and clinical outcome显示文摘 | Dedra S R Smallhorn J F Ryan G | 2002 | Circulation2002，105，5： | 1 |
| 5 | Conditions Comorbid with Chronic Fatigue in a Population-Based Sample显示文摘 | Elizabeth J. Dansie Helena Furberg Niloofar Afari Dedra Buchwald Karen Edwards Jack Goldberg Ellen Schur Patrick F. Sullivan | 2012 | Psychosomatics2012，，1： | 1 |
| 6 | Significant other responses are associated with fatigue and functional status among patients with chronic fatigue syndrome显示文摘 | Karen B Wayne R Dedra S | 2000 | Psychosomatic Medicine2000，62，： | 1 |
| 7 | Fetal cardiomyopathies pathogenic mechanisms,hemodynamic findings,and clinical outcome显示文摘 | Dedra S R Smallhom J F Ryan G | 2002 | circulation2002，105，5： | 1 |
| 8 | Significant other responses are associated with fatigue and functional status among patients with chronic fatigue syndrome显示文摘 | Karen B Wayne R Dedra S | 2000 | Psychosom Med2000，62，3： | 1 |
| 9 | Chronic Fatigue Syndrome: A Re-view 显示文摘 | Niioofar Afari and Dedra Buchwaid | 2003 | Am J Psychiatry2003，160，： | 1 |
| 10 | Chronic fatigue syndrome:a review显示文摘 | Niloofar Afari Dedra Buchwald | 2003 | Am J Psychiatry2003，160，： | 1 |
| 11 | Chronic fatigue syndrome:a review显示文摘 | Niloofar A Dedra B | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 12 | HBMMD: an enhanced database of the microorganisms associated with deeper water marine invertebrates显示文摘 | Aravinda S. Gunasekera Karen S. Sfanos Dedra K. Harmody Shirley A. Pomponi Peter J. McCarthy Jose V. Lopez | 2005 | Applied Microbiology and Biotechnology2005，，4： | 1 |
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