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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | Subseasonal features of the Asian summer monsoon in the NCEP climate forecast system显示文摘The operational climate forecast system(CFS)of the US National Centers for Environmental Prediction provides climate predictions over the world,and CFS products are becoming an important source of information for regional climate predictions in many Asian countries where monsoon climate dominates.Recent studies have shown that,on monthly-to-seasonal time-scales,the CFS is highly skillful in simulating and predicting the variability of the Asian monsoon.The higher-frequency variability of the Asian summer monsoon in the CFS is analyzed,using output from a version with a spectral triangular truncation of 126 waves in horizontal and 64 sigma layers in vertical,focusing on synoptic,quasi-biweekly,and intraseasonal time-scales.The onset processes of different regional monsoon components were investigated within Asia.Although the CFS generally overestimates variability of monsoon on these time-scales,it successfully captures many major features of the variance patterns,especially for the synoptic time-scale.The CFS also captures the timing of summer monsoon onsets over India and the Indo-China Peninsula.However,it encounters difficulties in simulating the onset of the South China Sea monsoon.The success and failure of the CFS in simulating the onset of monsoon precipitation can also be seen from the associated features of simulated atmospheric circulation processes.Overall,the CFS is capable of simulating the synoptic-to-intraseasonal variability of the Asian summer monsoon with skills.As for seasonal-to-interannual time-scales shown previously,the model is expected to possess a potential for skillful predictions of the high-frequency variability of the Asian monsoon. | Song YANG WEN Min R Wayne HIGGINS | 2008 | Acta Oceanologica Sinica2008，27，3： | 3 |
| 4 | Clostridium difficile Enteritis after Colectomy显示文摘 | Causey M Wayne Spencer Michael P Steele Scott R | 2009 | The American Surgeon2009，，12： | 2 |
| 5 | Microsatellites and their application to population genetic studies显示文摘 | BRUFORD M W WAYNE R K | 1993 | Current Opinion in Genetics and Development1993，3，： | 1 |
| 6 | Concurrent Use of Nonsteroidal Anti-inflammatory Drugs and Oral Anticoagulants Places Elderly Persons at High Risk for Hemorrhagic Peptic Ulcer Disease显示文摘 | Ronald I Wayne A James R | | 0，，： | 1 |
| 7 | COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease显示文摘 | Wayne A Ray C Michael Stein James R Daugherty Kathi Hall Patrick G Arbogast Marie R Griffin | 2002 | The Lancet2002，，9339： | 1 |
| 8 | Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice显示文摘 | Tirumalai R Jia Guo Wayne A | 2005 | J Exp Med2005，202，1： | 1 |
| 9 | High availability becoming highly necessary 显示文摘 | Wayne R | 1997 | AS/400 Systems Management1997，25，11： | 1 |
| 10 | An examina- tion of the mediating role of psychological empower- ment on the relations between the job,interpersonal relationships,and work outcomes显示文摘 | Liden R C Wayne S Sparrowe R T | 2000 | Journal of Ap- plied Psychology2000，85，3： | 1 |
| 11 | Tai Chi exercise in patients with chronic heart failure显示文摘 | YEH G Y WAYNE P M PHILLIPS R S | 2008 | Med Sport Sci2008，52，： | 1 |
| 12 | Controlled versus conventional drainage effects on water quality显示文摘 | Evans RO Wayne Skaggs R Wendell Gilliam J | 1995 | Journal of Irrigation and Drainage Engineering1995，121，4： | 1 |
| 13 | Relationship between in vitro chromosomal radiosensitivity of peripherial blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer显示文摘 | James B Wayne B Anne R | 2000 | Radiat Oncol2000，55，2： | 1 |
| 14 | Sources of support and expatriate performance: The mediating role of expatriate adjustment 显示文摘 | Kraimer M L Wayne S J Jaworski R A | 2001 | Personnel Psychology2001，54，1： | 1 |
| 15 | Ferrate(VI) oxidation ofaqueous cyanide显示文摘 | Virender K S Wayne R Jeremy O S’ | 1998 | Environmental Science & Technology1998，32，17： | 1 |
| 16 | Facts from feces revisited显示文摘 | KOHN M H WAYNE R K | 1997 | Trends in Ecology and Evolution1997，12，6： | 1 |
| 17 | Effects of photoperiod,temperature and salinity on hatchery- reared larvae of the greenback flounder (Rhombosolea tapirina G nther,1862)显示文摘 | Hart Piers R Hutchinson Wayne G Purser G | 1996 | Aquaculture1996，144，： | 1 |
| 18 | So- cial networks and the performance of individuals and groups 显示文摘 | Sparrowe R Liden R C Wayne S J Kraimer M L | 2001 | Academy of Management Journal2001，，44： | 1 |
| 19 | Perceived Organizational Support and Leader-Member Exchange : A Social Exchange Per- spective 显示文摘 | Wayne S J Shore L M Liden R C | 1997 | Academy of Management Journal1997，40，1： | 1 |
| 20 | Serum Uric Acid and Risk of Coronary Heart Disease显示文摘 | Joseph T Moriarity Aaron R Folsom Carlos Iribarren F.Javier Nieto Wayne D Rosamond | 2000 | Annals of Epidemiology2000，，3： | 1 |
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