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| 1 | Role of early life exposure and environment on neurodegeneration: implications on brain disorders显示文摘Neurodegenerative diseases such as Alzheimer’s disease(AD),Parkinson’s disease(PD),Amyotrophic lateral sclerosis(ALS)and retinal degeneration have been studied extensively and varying molecular mechanisms have been proposed for onset of such diseases.Although genetic analysis of these diseases has also been described,yet the mechanisms governing the extent of vulnerability to such diseases remains unresolved.Recent studies have,therefore,focused on the role of environmental exposure in progression of such diseases especially in the context of prenatal and postnatal life,explaining how molecular mechanisms mediate epigenetic changes leading to degenerative diseases.This review summarizes both the animal and human studies describing various environmental stimuli to which an individual or an animal is exposed during in-utero and postnatal period and mechanisms that promote neurodegeneration.The SNPs mediating gene environment interaction are also described.Further,preventive and therapeutic strategies are suggested for effective intervention. | Shweta Modgil Debomoy K Lahiri Vijay L Sharma Akshay Anand | 2014 | Translational Neurodegeneration2014，3，1： | 5 |
| 2 | DNA isolation by a rapid method from human blood samples: Effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality显示文摘 | Debomoy K. Lahiri Bill Schnabel | 1993 | Biochemical Genetics (-)1993，，7： | 2 |
| 3 | Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease显示文摘 | Kumar S Nigel HG Debomoy KL | 2002 | Neurol Mol Med2002，1，1： | 1 |
| 4 | A rapid non-enzymatic method for preparation of HMW DNA from blood for RFLP studies显示文摘 | Debomoy K L Nurnberger J I | 1991 | Nucleic Acids Research1991，19，： | 1 |
| 5 | Current drug targets for Alzheimer's disease treatment显示文摘 | Debomoy KL Martin R Farlow NH | 2002 | Drug Dev Res2002，56，： | 1 |
| 6 | Current drug targets for Alzheimer's disease treatment显示文摘 | Debomoy KL Martin R Farlow NH | 2002 | Drug Dev Res2002，56，： | 1 |
| 7 | Current drug targets for Alzheimer's disease treatment显示文摘 | Debomoy K L Martin R Farlow N H | 2002 | Drug Dev Res2002，56，： | 1 |
| 8 | Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity显示文摘 | Weiming Luo Qian-sheng Yu Isidro Salcedo Harold W. Holloway Debomoy K. Lahiri Arnold Brossi David Tweedie Nigel H. Greig | 2011 | Bioorganic & Medicinal Chemistry2011，，13： | 1 |
| 9 | A Rapid Non-enzymatic Method of the Preparation of HMW DNA Fromblood for RFLP Studies显示文摘 | DEBOMOY K L NUMBERGER J I | 1991 | Proc Nucleic Acid Res USA1991，19，： | 1 |
| 10 | DNA isolation by a rapid method from human blood samples: Effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality显示文摘 | Debomoy K. Lahiri Bill Schnabel | 1993 | Biochemical Genetics (-)1993，，7： | 1 |
| 11 | Epigenetics, oxidative stress, and Alzheimer disease显示文摘 | Nasser H. Zawia Debomoy K. Lahiri Fernando Cardozo-Pelaez | 2009 | Free Radical Biology and Medicine2009，，： | 1 |
| 12 | A rapid non-enzymatic method of the preparation of HMW DNA from blood for RFLP studies显示文摘 | NUMBERGER J I | 1991 | Proc Nucleic Acid Res U S A1991，19，： | 1 |
| 13 | Memantine treatment decreases levels of secreted Alzheimer’s amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells显示文摘 | Balmiki Ray Pradeep K. Banerjee Nigel H. Greig Debomoy K. Lahiri | 2009 | Neuroscience Letters2009，，1： | 1 |
| 14 | DNA isolation by a rapid method from human blood samples: effects of MgCI2 EDTA, storage time and temperature on DNA yield and quality显示文摘 | DEBOMOY K | 1993 | Biochem Genet1993，31，： | 1 |
| 15 | Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation显示文摘 | Stephen C. Bondy Huihui Li Jun Zhou Meixia Wu Jason A. Bailey Debomoy K. Lahiri | 2010 | Neurochemical Research2010，，12： | 1 |
| 16 | MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients显示文摘 | Justin M. Long Balmiki Ray Debomoy K. Lahiri | 2012 | Journal of Biological Chemistry2012，，37： | 1 |
| 17 | Advances in the cellu-lar and molecular biology of the beta-amyloid protein in Alzheimer's disease 显示文摘 | Kumar S Nigel H G Debomoy K L | 2002 | Neuromolecular Med2002，1，1： | 1 |
| 18 | Amyloid Precursor Protein and Alpha Synuclein Translation,Implications for Iron and Inflamma- tion in Neurodegenerative diseases 显示文摘 | Catherine M Debomoy K Xudong H | 2009 | National of Health Institutes2009，1790，7： | 1 |
| 19 | MicroRNA-101 downregulates Alzheimer's amyloid- precursor in human cell cultures and is differentially expressed 显示文摘 | Justin M Long Debomoy K Lahiri | 2011 | Biochemical and Biophysical Research Communications2011，404，： | 1 |
| 20 | Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors,phorbol ester,retinoic acid and interleukin-1显示文摘 | Debomoy K.Lahiri Christina N | | 0，，02： | 1 |
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