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| 1 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 2 | Glucoseresponsive polyelectrolyte capsules 显示文摘 | DE GEEST BG JONAS AM DEMEESTER J | 2006 | Langmuir2006，22，11： | 1 |
| 3 | Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels显示文摘 | Stubbe B G Horkay F Amsden B Hennink W E De Smedt S C Demeester J | 2003 | Biomacro-molecules2003，4，： | 1 |
| 4 | Swelling pressure observations on degrading dex-HEMA hydrogels 显示文摘 | Stubbe B G Braeckmans K Horkay F Hennink W E De Smedt S C Demeester J | 2002 | Maeromolecules2002，35，： | 1 |
| 5 | Hyaluronan : Preparation, Structure, Properties, and Applications 显示文摘 | Lapcik L De Smedt S Demeester J Chabrecek P | 1998 | Chem Rev1998，98，： | 1 |
| 6 | Ambulatory 24-H Esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility 显示文摘 | Jamieson JR stein H J deMeester TR | 1992 | Am J Gastroenterol1992，87，： | 1 |
| 7 | Diagnosis and management of synchronous lung cancers显示文摘 | Ferguson MK DeMeester TR DesLaauries J | 1985 | J Thorac Cardiovasc Surg1985，89，3： | 1 |
| 8 | Pore sizes in hydrated dextran mierospheres 显示文摘 | Stenekes RJ De Smedt SC Demeester J | 2000 | Biomaeromolecules2000，1，： | 1 |
| 9 | 'Programmed pol- ymeric devices' for pulsed drug delivery显示文摘 | Stubbe B G De Smedtand S C Demeester J | 2004 | Pharm Res2004，21，： | 1 |
| 10 | Design and evalu ation of doxorubicin-containing microbubbles {or ultra- sound-targeted doxorubicin delivery: cytotoxicity and mechanisms involvrd 显示文摘 | Lentacker I Geers B Demeester J | 2010 | Molecular Therapy2010，18，1： | 1 |
| 11 | Cationic polymer based gene delivery systems显示文摘 | DE SMEDT S C DEMEESTER J HENNINK W E | 2000 | Pharm Res2000，17，2： | 1 |
| 12 | 'Programmed polymerie devices' for pulsed drug delivery显示文摘 | Stubbe B G De Smedt S C Demeester J | 2004 | Pharm Res2004，21，： | 1 |
| 13 | Maintaining the silence:reflections on long-term RNAi显示文摘 | Raemdonck K Vandenbroucke R E Demeester J | 2008 | Drug Discovery Today2008，13，2122： | 1 |
| 14 | Tailoring the swelling pressure of degrading dextran hydroxyethyl methaerylate hydrogels显示文摘 | Stubbe B G Horkay F Amsden B Hennink W E De Smedt S C Demeester J | 2003 | Biomacro-molecules2003，4，： | 1 |
| 15 | Swelling pressure observations on degrading dex- HEMA hydrogels显示文摘 | Stubbe B G Braeckmans K Horkay F Hennink W E De Smedt S C Demeester J | 2002 | Maeromolecules2002，35，： | 1 |
| 16 | Management of gastric emptying disorders following the Roux-en-Y procedure显示文摘 | Hinder RA Esser J DeMeester TR | 1988 | Surgery1988，104，4： | 1 |
| 17 | Pulsed in vitro release and in uiuo behavior of explo- ding microcapsules显示文摘 | De Geest B G De Koker S Demeester J De Smedt S C Hen- nink W E | 2009 | J Contr Rel2009，185，： | 1 |
| 18 | Design and evaluation ot doxorubiein-containing microbubbles for ultrasound-triggered doxorubicin delivery:cytotoxicity and mechanisms involved 显示文摘 | Lentacker I Geers B Demeester J | 2010 | Mol Ther2010，18，1： | 1 |
| 19 | Pore sizes in hydrated dextran microspheres 显示文摘 | STENEKES R J De Smedt S C DEMEESTER J | 2000 | Biomacromolecule2000，，1： | 1 |
| 20 | Advanced nanogel engineering for drug delivery显示文摘 | RAEMDONCK K DEMEESTER J De SMEDT S | 2009 | Soft Matter2009，5，： | 1 |
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