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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | Hypothermic oxygenated perfusion for a steatotic liver graft显示文摘To the Editor:Donor steatosis represents a well-known risk factor for primary non-function,early allograft dysfunction,and biliary complications after liver transplantation(LT)[1,2].Recently,machine perfusion(MP)technology has been implemented in the clinical practice,with the primary intent to assess the graft quality and to optimize the organ selection process[3].A limited number of articles has been published specifically investigated the role of MP in steatotic livers[4–10],with few of them looking at the role of hypothermic MP. | Quirino Lai Franco Ruberto Fabio Melandro Zoe Larghi Laureiro Massimo Rossi Gianluca Mennini | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 7 |
| 3 | Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy:a systematic review显示文摘Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)represents an innovative surgical technique used for the treatment of large hepatic lesions at high risk for post-resection liver failure due to a small future liver remnant.The most significant amount of literature concerns the use of ALPPS for the treatment of hepatocellular carcinoma(HCC),cholangiocarcinoma(CCC),and colorectal liver metastases(CRLM).On the opposite,few is known about the role of ALPPS for the treatment of uncommon liver pathologies.The objective of the present study was to evaluate the current literature on this topic.A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.Eligible articles published up to February 2020 were included using the MEDLINE,Scopus,and Cochrane databases.Among the 486 articles screened,45 papers met the inclusion criteria,with 136 described cases of ALPPS for rare indications.These 136 cases were reported in 18 different countries.Only in two countries,namely Germany and Brazil,more than ten cases were observed.As for the ALPPS indications,we reported 41(30.1%)cases of neuroendocrine tumor(NET)metastases,followed by 27(19.9%)cases of gallbladder cancer(GBC),nine(6.6%)pediatric cases,six(4.4%)gastrointestinal stromal tumors,six(4.4%)adult cases of benign primary liver disease,four(2.9%)adult cases of malignant primary liver disease,and 43(31.6%)adult cases of malignant secondary liver disease.According to the International ALPPS Registry data,less than 10%of the ALPPS procedures have been performed for the treatment of uncommon liver pathologies.NET and GBC are the unique pathologies with acceptable numerosity.ALPPS for NET appears to be a safe procedure,with satisfactory long-term results.On the opposite,the results observed for the treatment of GBC are poor.However,these data should be considered with caution.The rationale for treating benign pathologies with ALPPS appears to be weak.No definitive response should be given for all the other pathologies.Multicenter studies are needed with the intent to clarify the potentially beneficial effect of ALPPS for their treatment. | Quirino Lai Gianluca Mennini Zoe Larghi Laureiro Massimo Rossi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 4 |
| 4 | GABA-A receptor impairment in the genetic absence epilepsy rats from strabourg ( GAERS ): an immunocytochemical and receptor binding autoradiographic study 显示文摘 | Spreafico R Mennini T Danober L | 1993 | Epilepsy Res1993，15，3： | 1 |
| 5 | Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis 显示文摘 | Villa P Bigini P Mennini T | 2003 | J Exp Med2003，198，6： | 1 |
| 6 | Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids 显示文摘 | Cirri M Maestrelli F Mennini N | 2009 | J Pharm BiomedAnal2009，50，5： | 1 |
| 7 | Nonhematopoietic eryth-ropoietin derivatives prevent motoneuron degeneration in vitro and in vivo显示文摘 | Mennini T De Paola M Bigini P | 2006 | Mol Med2006，12，78： | 1 |
| 8 | Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids 显示文摘 | Cirri M Maestrelli F Mennini N | 2009 | J Pharmceut Biomed2009，50，5： | 1 |
| 9 | Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis 显示文摘 | Villa P Bigini P Mennini T | 2003 | J Exp Med2003，198，6： | 1 |
| 10 | Erythropoietin selectively arsenates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis显示文摘 | Villa P Bigini P Mennini T | 2003 | Exp Ned2003，198，6： | 1 |
| 11 | Influence of the prepa- ration method on the physical-chemical properties of ketoprofen- cyclodextrin-phosphatidylcholine ternary systems显示文摘 | Cirri M Maestrelli F Mennini N | 2009 | J Pharm- ceut Biomed2009，50，5： | 1 |
| 12 | Quality by design approach for developing chitosan-Ca-alginate microspheres for colon delivery of celecoxib-hydroxypropyl-β-cyclodextrin-PVP complex显示文摘 | MENNINI N FURLANETTO S CIRRI M | 2012 | European Journal of Pharmaceutics and Biopharmaceutics2012，80，1： | 1 |
| 13 | Influence of the preparation method on the physical-chemical properlies of ketoprofen-cyclodextrin-phosphatidylcholine ternary systems 显示文摘 | Cirri Marzia Maestrelli Francesca Mennini Natascia | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，50，： | 1 |
| 14 | Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis显示文摘 | Villa P Bigini P Mennini T | 2003 | J Exp Med2003，198，6： | 1 |
| 15 | Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis显示文摘 | Bigini P Mennini T | 2003 | J Exp Med2003，198，： | 1 |
| 16 | Glutamate transporters in the spinal cord of the wobbler mouse显示文摘 | Bigini P Bastone A Mennini T | 2001 | Neuroreport2001，12，9： | 1 |
| 17 | Nonhematopoietie eryth- ropoietin derivatives prevent motoneuron degeneration in vitro and in vivo 显示文摘 | Mennini T De Paola M Bigini P | 2006 | Mol Med2006，12，78： | 1 |
| 18 | Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis显示文摘 | Villa P Bigini P Mennini T | 2003 | J Exp Med2003，198，6： | 1 |
| 19 | Erythropoietin selectivelyattenuates cytokine production and inflammation in cerebralischemia by targetingneuronal apoptosis显示文摘 | Villa P Bigini P Mennini T | 2003 | J Exp Med2003，198，6： | 1 |
| 20 | Improving care through health economies analyses: cost of illness and headaehe 显示文摘 | Mennini FS Gitto L Martelletti P | 2008 | Headache Pain2008，9，4： | 1 |
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