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| 1 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Shelf-EdgeErosion, Sediment Failure and Inception of BariCanyon on the Southwestern Adriatic Margin (CentralMediterranean)显示文摘 | Ridente D Foglini F Minisini D | 2007 | Marine Geology2007，246，234： | 1 |
| 3 | Molecular Dynamics Study of Specific Interactions in Grafted Polypropylene Organomodified Clay Nanocomposite显示文摘 | Minisini B Tsobnang F | 2005 | Composites:Part A2005，，36： | 1 |
| 4 | Overcoming treat-ment resistance in HER-2 -positive breast cancer: potential strat-egies显示文摘 | Puglisi F Minisini A M De Angelis C | 2012 | Drugs2012，72，9： | 1 |
| 5 | Topoisomer ase IIalpha and APE/ref-1 are associated with patho显示文摘 | Minisini AM Di LC Mansutti M | 2005 | Cancer Lett2005，224，13： | 1 |
| 6 | Baseline staging tests after a new diagnosis of breast cancer: further evidence of their limited in- dications显示文摘 | Puglist F Follador A Minisini AM | 2005 | Ann Oncol2005，16，： | 1 |
| 7 | Topoi- somerase Ilalpha and APE/ref- 1 are associated with pathologic response: to primary anthraeyeline- based chemotherapy for breast cancer 显示文摘 | Minisini AM Di Loreto C Mansutti M | 2005 | Cancer Lett2005，224，1： | 1 |
| 8 | Markers of the uPA system and common prognostic factors in breast cancer显示文摘 | Minisini AM Fabbro D Di Loreto C | 2007 | Am J Clin Pathol2007，128，1： | 1 |
| 9 | Chemotherapy for metastatic breast cancer显示文摘 | Biganzoli L Minisini A Aapro M | 2004 | Curr Opin Obstet Gynecol2004，16，7： | 1 |
| 10 | Taxane-induced nail chan- ges : incidence, clinical presentation and outcome 显示文摘 | Minisini AM Tosti A Sobrero AF | 2003 | Annals of On- cology2003，14，： | 1 |
| 11 | Opinion article:cytomegalo-virus is a risk factor in atherogenesis显示文摘 | Reinhardt B Minisini R Mertens T | 2002 | Herpes2002，9，1： | 1 |
| 12 | Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas显示文摘 | Puglisi F Aprile G Minisini A M | 2001 | Anticancer Res2001，21，6： | 1 |
| 13 | Chemotherapy for metastatic breast cancer显示文摘 | Bieanzoli L Minisini A Aapro M | 2004 | Curr Opin Obstet Gynecol2004，16，9： | 1 |
| 14 | Prognostic signifiance of Ape1 /ref-1 subcellar localization in non-small cell lung carcinomas显示文摘 | PUGLISI F APRILE G MINISINI A M | 2001 | Anticancer Res2001，21，6： | 1 |
| 15 | Determinants of recovery from amenorrhea in premenopausal breast cancer patients receiving adjuvant chemotherapy in the taxane era显示文摘 | Minisini AM Menis J Valent F | 2009 | Anticancer Drugs2009，20，6： | 1 |
| 16 | Analysis of beta1 and beta2-adrenergic receptors polymorphism in patients with apical ballooning cardiomyopathy显示文摘 | Vriz Q Minisini R Citro Rv | 2011 | Acta Cardiol2011，66，6： | 1 |
| 17 | Topoisomerase list and APE/ref-1 are associated with pathologic response to primary anthra- cycline-based chemotherapy for breast cancer显示文摘 | Minisini AM Loreto CD Mansutti M | 2005 | Cancer Left2005，224，1： | 1 |
| 18 | Overcoming treatment resistance in HER2- positive breast cancer: potential strategies显示文摘 | Puglisi F Minisini A De Angelis C | 2012 | Drugs2012，72，9： | 1 |
| 19 | Effective ta- crolimus treatment in a child suffering from severe nephrotic syndrome显示文摘 | Pennesi M Gagliardo A Minisini S | 2003 | Pediatr Nephrol2003，18，5： | 1 |
| 20 | Intramuscular drug transport under mechanical loading:resonance between tissue function and uptake显示文摘 | Wu PI Minisini S Edelman ER | 2009 | J Control Release2009，136，2： | 1 |
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