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| 1 | Handheld high-throughput plasmonic biosensor using computational on-chip imaging显示文摘We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. | Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug | 2014 | Light(Science & Applications)2014，3，1： | 6 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | 利用中链脂肪酸提高家禽遗传潜力显示文摘游离中链脂肪酸无论在病原体水平上和宿主水平上都呈现出对家禽生长有利的特性,因此,将中链脂肪酸作为家禽功能性饲料添加剂使用是应对目前家禽业面临的多种应激因素的有效方案。由于世界范围内不断减少抗生素生长促进剂(Antibacterial Growth Promoters,AGP)的使用,欧盟甚至禁止AGP的使用,家禽的肠道健康正成为一个非常重要的问题。由于肉鸡的育种持续地追求较快的生长速度和较高的饲料转化率,鸡肠道健康面临的压力变得不可测。 | 章薇 潘雪男 贾良梁 David Hermans Manu De Laet | 2015 | 国外畜牧学(猪与禽)2015，0，9： | 3 |
| 4 | Perifolliculitis capitis abscedens et suffodiens显示文摘 | Herman A David M Pitlik S | 1992 | Int J Dermatol1992，31，10： | 2 |
| 5 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 6 | A cooler way to drive 显示文摘 | Herman David | 1997 | Mechanical Engineering1997，119，12： | 1 |
| 7 | Direct numerical simulation of bubbly flow in the turbulent boundary layer of a horizontal parallel plate electrochemical reactor显示文摘 | Thomas Nierhaus David Vanden Abeele Herman Deconinek | 2007 | International Journal of Heat and Fluid Flow2007，28，： | 1 |
| 8 | Determining genetic contributions to host oyster shell growth: Quantitative trait loci and genetic association analysis for the silver-lipped pearl oyster, Pinctada maxima显示文摘 | David B. Jones Dean R. Jerry Mehar S. Khatkar Gerhard Moser Herman W. Raadsma Joseph J. Taylor Kyall R. Zenger | 2014 | Aquaculture2014，，： | 1 |
| 9 | Photodynamic treatment of neoplastic lesions of the gastrointestinal tract显示文摘 | John Webber Mark Herman David Kessel | 2000 | Langenbeck''s Arch Surg2000，385，： | 1 |
| 10 | Association Between Cardiovascular Autonomic Neuropathy and Left Ventricular Dysfunction in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study显示文摘 | Rodica Pop-Busui Patricia A. Cleary Barbara H. Braffett Catherine L. Martin William H. Herman Phillip A. Low Joao A.C. Lima David A. Bluemke | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 11 | Spatial Cognition in Natural-Language Narratives 显示文摘 | Herman David | | Technical Report0，9901，： | 1 |
| 12 | Three-dimensional reconst ruction of craniof acial deformity using computed tomography显示文摘 | Hemmy DC David DJ Herman GT | 1983 | Neurosurg1983，13，5： | 1 |
| 13 | Hypothetical Focalization显示文摘 | | 1994 | Narrative1994，2，： | 1 |
| 14 | 'Story Logic in Conversational and Literary Narratives'显示文摘 | Herman David | 2001 | Narrative2001，9，2： | 1 |
| 15 | Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database 1 1 No competing interests declared.显示文摘 | Stephen F Sener Amy Fremgen Herman R Menck David P Winchester | 1999 | Journal of the American College of Surgeons1999，，1： | 1 |
| 16 | Board practices of especially effective and less effective local nonProfit or ganizations显示文摘 | ROBERT D HERMAN DAVID O RENZ | 2000 | American Review of Public Administration2000，30，2： | 1 |
| 17 | Three-dimensional reconst ruction of craniof acial deformity using computed tomography 显示文摘 | Hemmy DC David DJ Herman GT | 1983 | Neurosurgery1983，13，5： | 1 |
| 18 | Photodynamic treatment of neoplastic lesions of the gastrointestinal tract显示文摘 | John Webber Mark Herman David Kessel David Fromm | 2000 | Langenbeck’s Archives of Surgery2000，，4： | 1 |
| 19 | The bottlenosed dolphin’s ( Tursiops truncatus ) understanding of gestures as symbolic representations of its body parts显示文摘 | Louis M. Herman David S. Matus Elia Y. K. Herman Marina Ivancic Adam A. Pack | 2001 | Animal Learning & Behavior2001，，3： | 1 |
| 20 | Sonolysis of chlorobenzene in aqueous solution: organic intermediates显示文摘 | David D Herman V L | 1998 | Ultrsonics Sonochemistry1998，，5： | 1 |
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