|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 3 | Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects显示文摘AIM To determine a potential relationship between serum undercarboxylated(uc OC) concentration and cardiovascular risk factors in type 2 diabetes(T2D) patients and healthy subjects(HS).METHODS A cross-sectional study was conducted on 140 subjects classified into two groups, 70 with T2D and 70 HS. Medical history and physical examination with anthropometric measurements were obtained from all subjects. Body fat percentage was determined by bioelectrical impendency analysis. Serum uc OC concentration was determined by enzyme immunoassay,while serum levels of insulin and hsC RP were obtained using high sensitivity enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment-IR. Lipid profile [triglycerides,total cholesterol(TC), high-density lipoproteins(HDL-c),low density lipoproteins(LDL-c), very low-density lipoproteins] was determined by spectrophotometry and standard formulas when applicable. RESULTS The T2D patient group showed significantly higher values of waist circumference, waist-to-hip ratio, systolic blood pressure(SBP), diastolic blood pressure(DBP),current smoking, and alcohol use when compared to the HS group(P < 0.05). We observed a significantly lower serum ucO C concentration in T2D than in HS(1.5 ± 1.4vs 2.3 ± 1.8, P < 0.05). In the whole study population,ucO C concentration was inversely correlated with body mass index(BMI)(r =-0.236, P < 0.05), fasting plasma glucose(r =-0.283, P < 0.01) and HDL-c(r =-0.255,P < 0.05); and positively correlated with LDL-c/HDL-c ratio(r = 0.306, P < 0.05) and TC/HDL-c ratio(r =0.284, P < 0.05). In the T2D group, serum uc OC concentration was inversely correlated with BMI(r =-0.310, P < 0.05) and body-fat percentage(r =-0.311,P < 0.05), and positively correlated with DBP(r = 0.450,P < 0.01). In HS group a positive correlation between serum levels of uc OC and SBP(r = 0.277, P < 0.05)was observed. CONCLUSION Serum uc OC is a potential marker for cardiovascular risk in Mexicans because it is related to adiposity parameters, blood pressure and lipid profile. | Sergio Sanchez-Enriquez Isabel Thalia Ballesteros-Gonzalez JoséRafael Villafán-Bernal Sara Pascoe-Gonzalez Edgar Alfonso Rivera-Leon Blanca Estela Bastidas-Ramirez Jorge David Rivas-Carrillo Juan Luis Alcala-Zermeno Juan Armendariz-Borunda Iris Monserrat Llamas-Covarrubias Abraham Zepeda-Moreno | 2017 | World Journal of Diabetes2017，8，1： | 6 |
| 4 | The catalysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，19，： | 1 |
| 5 | The cataysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，19，： | 1 |
| 6 | Multivariate image analysis (MIA) for industrial flare combustion control 显示文摘 | David C Rawlings B C Edgar T F | 2012 | Industrial & Engineering Chemistry Research2012，51，12： | 1 |
| 7 | The interlaminar tensile and shear behavior of a unidirectional C-C composite显示文摘 | Lam-Curzio Edgar Bowers David Ferber Mattison K | 1996 | Journal of Nuclear Materials1996，230，3： | 1 |
| 8 | The catalysis of biodiesel synthesis 显示文摘 | Edgar Lotero James G Goodwin David A Bruce | 2006 | Catalysis2006，19，： | 1 |
| 9 | Effect of moisture content on ammonia emissions from broiler litter: A laboratory study显示文摘 | Zifei Liu Lingjuan Wang David Beasley Edgar Oviedo | 2007 | Journal of Atmospheric Chemistry2007，，1： | 1 |
| 10 | Book Reviews: Fascism as a Mass Movement显示文摘 | David Edgar | 1977 | Race and Class1977，19，2： | 1 |
| 11 | Sub-ambient temperature flue gas carbon dioxide capture via Matrimid ? hollow fiber membranes显示文摘 | Lu Liu Edgar S. Sanders Sudhir S. Kulkarni David J. Hasse William J. Koros | 2014 | Journal of Membrane Science2014，，： | 1 |
| 12 | Routine uhrasonography compared with maternal serum alphafe to protein for neural tube defect screening 显示文摘 | Carol TN Edgar JS David LW | 2005 | Am J Obstet Gynecol2005，106，4： | 1 |
| 13 | Electric stimula-tion as an adjunct to heal diabetic foot ulcers i A Ran-domized Clinical Trial 显示文摘 | Edgar J Lawrence A David G | 2001 | Arch Phys Med Rehabil2001，82，： | 1 |
| 14 | The catalysis of biodiesel synthesis显示文摘 | Edgar L James G G David A B | 2006 | Catalysis2006，，19： | 1 |
| 15 | The catalysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，19，： | 1 |
| 16 | The cataysis of biodiesel synthesis显示文摘 | Lotero Edgar Goodwin James G Bruce David A | 2006 | Catalysis2006，，19： | 1 |
| 17 | Chronic alcohol consumption lowers blood pressure but enhances vascular contractility in Wistar rats显示文摘 | Daniel C. Hatton Richard D. Bukoski Scott Edgar David A. McCarron | 1992 | Journal of Hypertension1992，，6： | 1 |
| 18 | Genetic factors conferring an increased susceptibility to develop Crohn’s disease also influence disease phenotype: results from the IBDchip European Project显示文摘 | Isabelle Cleynen Juan R González Carolina Figueroa Andre Franke Dermot McGovern Martin Bortlík Bart J A Crusius Maurizio Vecchi Marta Artieda Magdalena Szczypiorska Johannes Bethge David Arteta Edgar Ayala Silvio Danese Ruud A van Hogezand Julian Panés Sa | 2013 | Gut2013，，11： | 1 |
| 19 | Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT)显示文摘 | Wojciech Zareba Helmut Klein Iwona Cygankiewicz W. Jackson Hall Scott McNitt Mary Brown David Cannom James P. Daubert Michael Eldar Michael R. Gold Jeffrey J. Goldberger Ilan Goldenberg Edgar Lichstein Heinz Pitschner Mayer Rashtian Scott Solomon Sami Vis | 2011 | Circulation2011，，： | 1 |
| 20 | Minimally invasive vitreoretinal surgery 显示文摘 | Ron PG Edgar LT David SB | 2002 | Review of Ophthalmology2002，9，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员