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| 1 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 2 | Environmental records of lacustrine sediments in different time scales:Sediment grain size as an example显示文摘Sediment grain size is a conventional proxy of climatic changes. Larger sediment grain size is often interpreted to indicate dry climate during lower lake level while smaller sedi- ment grain size implies wet climate during higher lake level. Through detailed study on sediment grain sizes in Lake Erhai and Lake Chenghai, this paper reveals the different indication signifi- cances of sediment grain sizes in different time scales, different resolution investigations. For long time-scale and low resolution (102a or 103a) studies, larger sediment grain size indicates lower lake level, smaller lake area and drier climate while smaller sediment grain size indicates higher lake level, larger lake area and wetter climate. For short time-scale and high resolution (a or 10a) studies, larger sediment grain size reflects more rainfall and wetter climate while smaller sediment grain size reflects less rainfall and drier climate. Environmental information revealed by lacustrine sediment records is often different in different time scales because of the variance of sedimentation resolution, sampling resolution and dating precision. Therefore, paleoclimate im- plications of environmental proxies in long time-scale and low resolution investigations could not be mechanically applied to short time-scale and high resolution studies. Only after synthetically analyzing the influence manner and extent of all factors on the sediment records in different time scales, can credible conclusions be obtained. | CHEN Jing’an1, WAN Guojiang1, David Dian Zhang2, ZHANG Feng1 & HUANG Ronggui1 1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geography and Geology, University of Hong Kong, Pokfulam Road, Hong Kong, China | 2004 | Science China Earth Sciences2004，47，10： | 27 |
| 3 | Grass height and transmission ecology of Echinococcus multilocularis in Tibetan communities, China显示文摘背景牙槽的包虫病是在西方的中国的公共健康意义的主要动物病。过度放牧最近为牙槽的包虫病的传播作为一个潜在的风险因素被假定。研究被设计进一步由调查过度放牧怎么影响了中间的主人的洞穴密度测试过度放牧的假设小哺乳动物并且小哺乳动物的洞穴密度怎么与狗包虫 multilocularis infection.Methods 被联系学习地点被发现了牙槽的包虫病是流行的区域的以前的研究选择。数据包括草高度,挖中间的主人的密度烘便的样品以及全球放系统(GPS ) 放的小哺乳动物,狗和狐狸,在 Shiqu 县从领域调查被收集,四川省,中国。烘便的样品用 copro-PCR 被分析。在烘便的样品的蠕虫,牙齿,骨头和头发视觉上被检验。包括 chi 平方和概括线性模型的单个因素和 multifactor 分析工具被把草高度用作在同质的牧场擦伤压力的一个代理用于这些 data.Results ,在导致的牧场发现那棵更高的草的这研究降低小哺乳动物的洞穴密度 X^2=A.67O , P=0.031 , coefficient=-1.570 )。在狗的包虫 multilocularis 蠕虫负担是显著地统计上与中介的最大的密度有关招待 Ochotona spp。(X^2=5.250, P=0.022, coefficient=0.028 ) 。在拥有的狗的流行断然被相关到在 200 米半径以内看见的迷路的狗的数字(Wald X^2=8.375, P=0.004,机会 ratio=1.198 ) 。结论我们的调查结果支持过度放牧支持的假设牙槽的包虫病的传播并且在牙槽的包虫病的传播证实迷路的狗的角色。 | WANG Qian Francis Raoul Christine Budke Philip S. Craig XIAO Yong-fu, Dominique A. Vuitton,Maiza Campos-Ponce, QIU Dong-chuan, David Pleydell and Patrick Giraudoux XIAO Yong-fu Dominique A. Vuitton Maiza Campos-Ponce QIU Dong-chuan David Pleydell Patrick Giraudoux | 2010 | Chinese Medical Journal2010，，1： | 12 |
| 4 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 5 | Advancement toward Polymer Electrolyte Membrane Fuel Cells at Elevated Temperatures显示文摘Elevation of operational temperatures of polymer electrolyte membrane fuel cells(PEMFCs)has been demonstrated with phosphoric acid-doped polybenzimidazole(PA/PBI)membranes.The technical perspective of the technology is simplified construction and operation with possible integration with,e.g.,methanol reformers.Toward this target,significant efforts have been made to develop acid-base polymer membranes,inorganic proton conductors,and organic-inorganic composite materials.This report is devoted to updating the recent progress of the development particularly of acid-doped PBI,phosphate-based solid inorganic proton conductors,and their composite electrolytes.Long-term stability of PBI membranes has been well documented,however,at typical temperatures of 160℃.Inorganic proton-conducting materials,e.g.,alkali metal dihydrogen phosphates,heteropolyacids,tetravalent metal pyrophosphates,and phosphosilicates,exhibit significant proton conductivity at temperatures of up to 300℃ but have so far found limited applications in the form of thin films.Composite membranes of PBI and phosphates,particularly in situ formed phosphosilicates in the polymer matrix,showed exceptionally stable conductivity at temperatures well above 200℃.Fuel cell tests at up to 260℃ are reported operational with good tolerance of up to 16%CO in hydrogen,fast kinetics for direct methanol oxidation,and feasibility of nonprecious metal catalysts.The prospect and future exploration of new proton conductors based on phosphate immobilization and fuel cell technologies at temperatures above 200℃ are discussed. | Jin Zhang David Aili Shanfu Lu Qingfeng Li and San Ping Jiang | 2020 | Research2020，，1： | 6 |
| 6 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 7 | Twinning in Intermetallic Compounds Are Long Shear Vectors and/or Shuffles Really Necessary?显示文摘In this paper the geometric description and general theory of mechanical twinning are reviewed, the twins in general lattices and superlattices are summarized, and the kinetic process by which mechanical twins form is revisited. A case study of mechanical twinning of HfV2+Nb, (cubic) Laves phase, is presented and the synchroshear of selected atomic layers is proposed to explain the physical process of twin formation. If the twins form in this way, then long shear vectors and / or atomicshuffles are not really necessary. | F.M.Chu David P.Pope Dept.of Materials Science and Engineering,University of Pennsylvania,Philadelphia,PA 19104,USA | 1993 | Journal of Materials Science & Technology1993，9，5： | 4 |
| 8 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 9 | Comparing models of mental health service systems between Australia and China: implications for the future development of Chinese mental health service显示文摘 | LIU Tie-qiao Ng Chee MA Hong David Castle HAO Wei LI Ling-jiang and | 2008 | Chinese Medical Journal2008，，14： | 3 |
| 10 | Recent Near-surface Temperature Trends in the Antarctic Peninsula from Observed,Reanalysis and Regional Climate Model Data显示文摘This study investigates the recent near-surface temperature trends over the Antarctic Peninsula.We make use of available surface observations,ECMWF’s ERA5 and its predecessor ERA-Interim,as well as numerical simulations,allowing us to contrast different data sources.We use hindcast simulations performed with Polar-WRF over the Antarctic Peninsula on a nested domain configuration at 45 km(PWRF-45)and 15 km(PWRF-15)spatial resolutions for the period 1991?2015.In addition,we include hindcast simulations of KNMI-RACMO21P obtained from the CORDEX-Antarctica domain(~50 km)for further comparisons.Results show that there is a marked windward warming trend except during summer.This windward warming trend is particularly notable in the autumn season and likely to be associated with the recent deepening of the Amundsen/Bellingshausen Sea low and warm advection towards the Antarctic Peninsula.On the other hand,an overall summer cooling is characterized by the strengthening of the Weddell Sea low as well as an anticyclonic trend over the Amundsen Sea accompanied by northward winds.The persistent cooling trend observed at the Larsen Ice Shelf station is not captured by ERA-Interim,whereas hindcast simulations indicate that there is a clear pattern of windward warming and leeward cooling.Furthermore,larger temporal correlations and lower differences exhibited by PWRF-15 illustrate the existence of the added value in the higher spatial resolution simulation. | Deniz BOZKURT David HBROMWICH Jorge CARRASCO Keith MHINES Juan Carlos MAUREIRA and Roberto RONDANELLI | 2020 | Advances in Atmospheric Sciences2020，37，5： | 3 |
| 11 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 12 | Macroinvertebrate assemblages of surface mine wetlands of Southwest Virginia,USA显示文摘MacroinvertebrateassemblagesofsurfaceminewetlandsofSouthwestVirginia,USA￥DavidH.Jones;RobertB.Atkinson;JohnCairns,Jr.(Departm... | David H.Jones Robert B. Atkinson John Cairns,Jr.(Department of Biology,Virginia Polytechnic Institute and State University, Blacksburg,Virginia 24061 USA) | 1996 | Journal of Environmental Sciences1996，8，1： | 2 |
| 13 | New treatments for inflammatory bowel disease显示文摘INTRODUCTIONAlthoughinflammatoryboweldisease(IBD)isapparentlystilrelativelyrareintheEast,evidencefromHongKongsuggeststhatover... | David S. Rampton and D.Phil | 1998 | World Journal of Gastroenterology1998，4，5： | 2 |
| 14 | Investigating the Synthesis of RBF Networks显示文摘InvestigatingtheSynthesisofRBFNetworks￥V.DavidSanchezA.(GermanAerospaceResearchEstablishment,DLROberpfaffenhofenInstituteforR... | V. David Sanchez A.(German Aerospace Research Establishment, DLR OberpfaffenhofenInstitute for Robottes and System DynamicsD-82230 Wessling, Germany) | 1996 | Journal of Systems Engineering and Electronics1996，7，3： | 2 |
| 15 | Comparison of neural network models with ARIMA and regression models for prediction of Houston's daily maximum ozone concentrations 显示文摘 | Victor R Prybutok Junsub Yi and David Mitchell | 2000 | European Journal of Operational Research2000，122，： | 1 |
| 16 | Some Thought about the Neurobiology of Regeneration显示文摘 | Memory and the Brain | 2001 | The New Philosophy2001，2001，： | 1 |
| 17 | Currency competition, network externalities and switching costs: towards an alternative view of optimum currency areas显示文摘 | Dowd Kevin and Greenaway David | 1993 | The Economic Journal1993，103，420： | 1 |
| 18 | The Role of Technology in the Shift towards Open Innovation:the Case of Procter & Gamble显示文摘 | Mark Dodgson1 David Gann2 and Ammon Salter | 2006 | R&D Management2006，36，3： | 1 |
| 19 | Social impacts of Sydney Olympics显示文摘 | Waitt G Jerry Johnson David J Senpenger and Sevgin Akis | 2003 | Annals of Tourism Research2003，30，1： | 1 |
| 20 | The Nature and Growth of Vertical Specialization in World Trade 显示文摘 | Hummels David Jun Ishii and Kei- Mu Yi | | Journal of0，，： | 1 |
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