|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 3 | Starburst dendrimers : molecular - level control of size, shape, surface chemistry, topology,and flexibility from Atoms to macroscopic matter显示文摘 | Tomalia DA Naylor AM Gaddar Ⅲ WA | 1990 | Angewandte Chem Inter Edition in English1990，29，： | 1 |
| 4 | The evolutionary history of chromosomal super integrons provides an ancestry for multiresistant integrons显示文摘 | Rowe-Magnus DA Guerout AM Ploncard P | 2001 | Pro Natl AcaSci USA2001，98，2： | 1 |
| 5 | The genotoxic and cytotoxic activities of inorganic fluoride in cultured rat bone marrow cells 显示文摘 | Khalil AM Da'dara AA | 1994 | Arch Environ Contam Toxicol1994，26，1： | 1 |
| 6 | A heat - sensitive TRP chan- nel expressed in keratinocytes 显示文摘 | Peier AM Reeve AJ Andersson DA | 2002 | Science2002，296，5575： | 1 |
| 7 | Prevalent vertebral fractures among children initiating glueocortieoid therapy for the treatment of rheumatic disorders 显示文摘 | Huber AM Gaboury I Cabral DA | 2010 | Arthritis Care Res (Hobo- ken)2010，62，： | 1 |
| 8 | The site of brains tern lesions causing semicircular canal paresis:an MRI study显示文摘 | Francis DA Bronstein AM Rudge P | 1992 | J Neurol Neurosurg Psychiatry1992，55，： | 1 |
| 9 | Suspected ciliary block associated viscoat use 显示文摘 | Berger RR Kenyeres AM Powell DA | 1999 | J Cataract Refract Surg1999，25，4： | 1 |
| 10 | Persistent purulent drainage from the glans penis: atypical presentation of pyodenna gangrenosum显示文摘 | Gonzalgo ML de Lacerda DA De Marzo AM | 2003 | J Urol2003，169，5： | 1 |
| 11 | A specific immunoassay for mornitoring human bone resorption:quantitation of type I collagen cross-linked N-telopeptides in urine显示文摘 | Hanson DA Weis MA Bollen AM | 1992 | J Bone Miner Res1992，7，： | 1 |
| 12 | Drug-load- ed nano/microbubbles for combining ultrasonography and targeted chemotherapy显示文摘 | Gao Z Kennedy AM Christensen DA | 2008 | Ultrasonics2008，48，4： | 1 |
| 13 | Com- parative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae 显示文摘 | Rowe Magnus DA Guerout AM Biskri L etal | 2003 | Genome Res2003，13，3： | 1 |
| 14 | Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy显示文摘 | Gao Z Kennedy AM Christensen DA | | 0，，04： | 1 |
| 15 | Integrating best evidence into patient care: a process facilitated by a seamless integration with informatics tools显示文摘 | Giuse NB Williams AM Giuse DA | 2010 | J Med Libr Assoc2010，98，3： | 1 |
| 16 | Three-dimensional rotational angiographic detection of in-stent stenosis in wide-necked aneurysms treated with a self-expanding intracranial stent 显示文摘 | Hoit DA Malek AM | 2005 | Neurosurgery2005，57，6： | 1 |
| 17 | The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis 显示文摘 | Elsharkawy AM Oakley F Mann DA | 2005 | Apoptosis2005，10，5： | 1 |
| 18 | Modulation of macrophage and microglial responses to axonal injury in the peripheral and central nervous systems显示文摘 | Lazar DA Ellegala DB Avellino AM | 1999 | Neurosurgery1999，45，3： | 1 |
| 19 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 20 | Targeted delivery of antibody -based therapeutic and imaging agents to CNS tumors:Crossing the blood - brain - barrier divide显示文摘 | Chacko AM Li C Pryma DA | 2013 | Expert Opinion On Drug Delivery2013，10，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员