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| 1 | The molecular machinery of regulated cell death显示文摘Cells may die from accidental cell death(ACD)or regulated cell death(RCD).ACD is a biologically uncontrolled process,whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms.A growing number of novel nonapoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies.Here,we critically review the current state of the art regarding non-apoptotic types of RCD,including necroptosis,pyroptosis,ferroptosis,entotic cell death,netotic cell death,parthanatos,lysosome-dependent cell death,autophagy-dependent cell death,alkaliptosis and oxeiptosis.The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidanee of pathogenic cell loss. | Daolin Tang Rui Kang Tom Vanden Berghe Peter Vandenabeele Guido Kroemer | 2019 | Cell Research2019，29，5： | 143 |
| 2 | Ferroptosis:molecular mechanisms and health implications显示文摘Cell death can be executed through different subroutines.Since the description of ferroptosis as an iron-dependent form of nonapoptotic cell death in 2012,there has been mounting interest in the process and function of ferroptosis.Ferroptosis can occur through two major pathways,the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants,which is driven by the abnormal expression and activity of multiple redox-active enzymes that produce or detoxify free radicals and lipid oxidation products.Accordingly,ferroptosis is precisely regulated at multiple levels,including epigenetic,transcriptional,posttranscriptional and posttranslational layers.The transcription factor NFE2L2 plays a central role in upregulating anti-ferroptotic defense,whereas selective autophagy may promote ferroptotic death.Here,we review current knowledge on the integrated molecular machinery of ferroptosis and describe how dysregulated ferroptosis is involved in cancer,neurodegeneration,tissue injury,inflammation,and infection. | Daolin Tang Xin Chen Rui Kang Guido Kroemer | 2021 | Cell Research2021，31，2： | 182 |
| 3 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 4 | Cuproptosis:a copper-triggered modality of mitochondrial cell death显示文摘Various heavy metals can induce regulated cell death through different subroutines.A recent study published in Science found that intracellular copper accumulation triggers the aggregation of mitochondrial lipoylated proteins and the destabilization of Fe–S cluster proteins,leading to a unique type of cell death termed cuproptosis.Beyond classical apoptosis,several forms of regulated cell death(RCD)have been identified.These RCD subroutines differ in the initiating stimuli,intermediate activation events,and end effectors.1 Heavy metal ions are essential micronutrients,but either insufficient or excessive abundance of metals can trigger cell death.For example,ferroptosis has been defined as an iron-dependent form of oxidative cell death caused by unrestricted lipid peroxidation.2 Surprisingly,a recent study by Tsvetkov and colleagues showed that intracellular copper(Cu)induces a novel form of RCD that is different from oxidative stress-related cell death(e.g.,apoptosis,ferroptosis,and necroptosis)and has been termed“cuproptosis”.3 In contrast,mitochondrial stress,especially the aggregation of lipoylated mitochondrial enzymes and the loss of Fe–S cluster proteins,ignites cuproptosis(Fig.1). | Daolin Tang Xin Chen Guido Kroemer | 2022 | Cell Research2022，32，5： | 19 |
| 5 | Occurrence of odor problems in drinking water of major cities across China显示文摘进在越过中国的主要城市里的 111 喝的水处理植物(DWTP ) 的气味问题的出现的全面调查用两风味侧面分析(FPA ) 和煤气的层析团 spectrometry (GCMS ) 被承担。百分之八十件来源水样品展出了气味问题,描绘了由土 / 霉(41%) 并且沼泽 / 腐败(36%) 气味,当出现率更低时(45%) 在完成的水里。当那从湖和水库展出了更多的 algaeorigin 气味时,来自河的来源水展出了更多的污染起源气味,例如沼泽 / 腐败的气味,例如土 / 霉的气味。在表面来源水样品的 2-methylisoborneol (2-MIB ) 的出现率是 75% ,与包含超过 10 ng 的 2-MIB 集中的 7% | Daolin SUN Jianwei YU Min YANG Wei AN Yunyun ZHAO Ning LU Shengguang YUAN Dongqing ZHANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，3： | 15 |
| 6 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 7 | Extraction of Lithium from Salt Lake Brine with Triisobutyl Phosphate in Ionic Liquid and Kerosene显示文摘 | GAO Daolin YU Xiaoping GUO Yafei WANG Shiqiang LIU Mingming DENG Tianlong CHEN Yuwei BELZILE Nelson | 2015 | Chemical Research in Chinese Universities2015，31，4： | 10 |
| 8 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hxvfb0b09wc9n6q9c.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hxvfb0b09wc9n6q9c.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 9 | Insights into the differences in leaf functional traits of heterophyllous Syringa oblata under different light intensities显示文摘Many plants exhibit heterophylly; the spatially and temporally remarkable ontogenetic differences in leaf morphology may play an adaptative role in their success under diverse habitats. Thus, this study aimed to gain insights into differences in leaf functional traits of heterophyllous Syringa oblata Lindl., which has been widely used as an ornamental tree around the world under different light intensities in East China. No significant differences existed in specific leaf area(SLA) between lanceolate- and heart-shaped leaves. Differences in the investment per unit of light capture surface area deployed between lanceolate- and heart-shaped leaves may be not obvious. This may be attributing to the fact that single leaf wet and dry weight of heart-shaped leaves were significantly higher than those of lanceolate leaves but leaf length and leaf thickness of heart-shaped leaves were significantly lower than those of lanceolate leaves. The SLA of shade trees was significantly higher than that of sun trees. The investment per unit of light capture surface of shade trees was lower than that of sun trees, making it possible to increase light capture and use efficiency in low-light environments. The phenotypic plasticity of most leaf functional traits of lanceolate leaves was higher than those of heart-shaped leaves because the former is the juvenile and the latter is the adult leaf shape during the process of phylogenetic development of S. oblate. The higher range of phenotypic plasticity of leaf thickness and leaf moisture for sun trees may be beneficial to obtain a more efficient control of water loss and nutrient deprivation in highlight environments, and the lower range of phenotypic plasticity of single leaf wet and dry weight, and SLA for shade trees may gain an advantage to increase resource(especially light) capture and use efficiency in low-light environments. In brief, the successfully ecological strategy of plants is to find an optimal mode for the trade-off between various functional traits to obtain more living resources and achieve more fitness advantage as much as possible in the multivariate environment. | Hongguang Xiao Congyan Wang Jun Liu Lei Wang Daolin Du | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 10 | Leukocyte Membrane-Coated Liquid Metal Nanoswimmers for Actively Targeted Delivery and Synergistic Chemophotothermal Therapy显示文摘We report a leukocyte membrane-coated gallium nanoswimmer(LMGNS)capable of ultrasound-propelled motion,antibiofouling,and cancer cell recognition and targeting.The LMGNS consists of a needle-shaped gallium core encapsulating an anticancer drug and a natural leukocyte membrane shell.Under the propulsion of an ultrasound field,LMGNSs could autonomously move in biological media with a speed up to 108.7μms^(-1).The velocity and motion direction of the LMGNSs can be modulated by regulating the frequency and voltage of the applied ultrasound field.Owing to the leukocyte membrane coating,LMGNSs can not only avoid biofouling during the motion in blood but also possess cancer cell recognition capability.These LMGNSs could actively seek,penetrate,and internalize into the cancer cells and achieve enhanced anticancer efficiency by combined photothermal and chemical therapy.Such biofunctionalized liquid metal nanoswimmer presents a new type of multifunctional platform for biomedical applications. | Daolin Wang Changyong Gao Chang Zhou Zhihua Lin Qiang He | 2020 | Research2020，，1： | 8 |
| 11 | Identification of causative compounds and microorganisms for musty odor occurrence in the Huangpu River,China显示文摘There are regular problems of musty odor in the Huangpu River,a major source of drinking water for Shanghai,China.In this study,the musty odor and its main causative compounds in the Huangpu River source water were confirmed through a yearly investigation using flavor profile analysis combined with HSPME-GC-MS analysis.The investigation showed that 2-methylisoborneol (2-MIB) with a concentration level between 28.6 and 71.0 ng/L was responsible for the musty odor in summer from July to September.Microscopic observation confirmed with the cloning results showed that Phormidium spp.,which accounted for 80%-95% of the algal cell density,was the microorganisms responsible for the production of 2-MIB and the estimated 2-MIB yield was 0.022 pg/cell.Results from a wide-area sampling campaign in the Huangpu River watershed showed that,other than the large tributaries receiving water from Tai Lake,several small creeks close to the intake may have contributed most of the 2-MIB and the Phormidium spp.to the Huangpu River source water.This study provides methodology for the investigation of odor causing compounds and microorganisms in river-type source water,and the result will be useful for water quality control in both source water and drinking water. | Daolin Sun Jianwei Yu Wei An Min Yang Guoguang Chen Shujun Zhang | 2013 | Journal of Environmental Sciences2013，25，3： | 6 |
| 12 | Numerical and Experimental Investigations on Tunable Low-frequency Locally Resonant Metamaterials显示文摘In this paper,a tunable locally resonant metamaterial is proposed for low-frequency band gaps.The local resonator composed of two pairs of folded slender beams and a proof mass is designed based on the theory of compliant mechanism.The design optimization on geometric parameters is carried out to fulfil the quasi-zero-stiffness property.The locally resonant metamaterial is formed by periodically arranged unit cells,and the transmittance of longitudinal wave is studied through three aspects:numerical predictions,finite element simulations and experimental tests.The variation trends revealed by these three methods match well with one another:the band gap moves to lower frequency and both its depth and width get smaller and smaller with the increase of pre-compression(Δ).The band gap overlays the frequency range of 73.10–92.38 Hz and 16.78–19.49 Hz atΔ=0mm andΔ=10mm,respectively,providing a wide range of tunability.Besides,the ultralow-frequency band gap can be achieved asΔapproaches 10 mm.This study may provide an avenue for achieving the tunable ultralow-frequency locally resonant band gap. | Qida Lin Jiaxi Zhou Hongbin Pan Daolin Xu Guilin Wen | 2021 | Acta Mechanica Solida Sinica2021，34，5： | 4 |
| 13 | Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells.Recent works have revealed that the dynamic interaction between cancer cells and neuronal cells leads to perineural invasion(PNI),a clinical pathological feature of PDAC.The formation and function of PNI are dually regulated by molecular(e.g.,involving neurotrophins,cytokines,chemokines,and neurotransmitters),metabolic(e.g.,serine metabolism),and cellular mechanisms(e.g.,involving Schwann cells,stromal cells,T cells,and macrophages).Such integrated mechanisms of PNI not only support tumor development,growth,invasion,and metastasis but also mediate the formation of pain,all of which are closely related to poor disease prognosis in PDAC.This review details the modulation,signaling pathways,detection,and clinical relevance of PNI and highlights the opportunities for further exploration that may benefit PDAC patients. | Jingbo Li Rui Kang Daolin Tang | 2021 | Cancer Communications2021，41，8： | 4 |
| 14 | The BET family in immunity and disease显示文摘Innate immunity serves as the rapid and frst-line defense against invading pathogens,and this process can be regulated at various levels,including epigenetic mechanisms.The bromodomain and extraterminal domain(BET)family of proteins consists of four conserved mammalian members(BRD2,BRD3,BRD4,and BRDT)that regulate the expression of many immunity-associated genes and pathways.In particular,in response to infection and sterile inflammation,abnormally expressed or dysfunctional BETs are involved in the activation of pattern recognition receptor(e.g,TLR,NLR,and CGAS)pathways,thereby linking chromatin machinery to innate immunity under disease or pathological conditions.Mechanistically,the BET family controls the transcription of a wide range of proinflammatory and immunoregulatory genes by recognizing acetylated histones(mainly H3 and H4)and recruiting transcription factors(e.g.,RELA)and transcription elongation complex(e.g.P-TEFb)to the chromatin,thereby promoting the phosphorylation of RNA polymerase II and subsequent transcription initiation and elongation.This review covers the accumulating data about the roles of the BET family in innate immunity,and discusses the attractive prospect of manipulating the BET family as a new treatment for disease. | Nian Wang Runliu Wu Daolin Tang Rui Kang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 4 |
| 15 | Agricultural land loss in China's urbanization process显示文摘In China, urbanization of agricultural land around city agglomerations increases rapidly. Rapid urbaniza-tion of agricultural land affects food supply, land value and ecological balance in the society. In China, the urban built-up area had increased by 40% from 1996 to 2003. This increase came predominantly from farmland surrounding thecities. How the ongoing urbanization of China affects its agricultural land is the focus of this paper. In current studies, wehave found that population density; urbanization degree and personal income are key factors that influence the urbaniza-tion process. Based on this, relation model has been established and to predict the general trends of the urban areaexpansion in China in 2020. In 2020, the constructed urban area of China would be increased by 1.3 times compared with2003. In 2020, this study anticipates the conversion of about 32,562 sq. km. agricultural land of China for urban use. | Li Xiaoyun Cai Yinyin Zhu Daolin Zhang Anlu | 2006 | Ecological Economy2006，2，1： | 3 |
| 16 | A Phase Change Memory Chip Based on Ti Sb Te Alloy in 40-nm Standard CMOS Technology显示文摘In this letter, a phase change random access memory(PCRAM) chip based on Ti0.4Sb2Te3 alloy material was fabricated in a 40-nm 4-metal level complementary metal-oxide semiconductor(CMOS) technology. The phase change resistor was then integrated after CMOS logic fabrication. The PCRAM was successfully embedded without changing any logic device and process, in which 1.1 V negative-channel metal-oxide semiconductor device was used as the memory cell selector. The currents and the time of SET and RESET operations were found to be 0.2 and 0.5 m A, 100 and 10 ns,respectively. The high speed performance of this chip may highlight the design advantages in many embedded applications. | Zhitang Song Yi Peng Zhan Daolin Cai Bo Liu Yifeng Chen Jiadong Ren | 2015 | Nano-Micro Letters2015，7，2： | 2 |
| 17 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 18 | 生物入侵过程中的植物-土壤反馈:一种入侵植物的凋落物分解对其本地近缘植物的影响显示文摘植物入侵可通过正或负的植物-土壤反馈效应改变土壤的生物和非生物性质,从而影响入侵栖息地的土壤理化性质。许多入侵物种的凋落物分解可增加土壤养分,降低本地植物多样性,并导致进一步的植物入侵。关于入侵植物凋落物在不同土壤类型及深度分解及反馈效应的研究依然很少。本研究旨在明确入侵植物南美蟛蜞菊(Sphagneticola trilobata)凋落物在不同土壤类型和不同土壤深度条件下的分解情况及其对本地近缘植物蟛蜞菊(S.calendulacea)生理生长的影响。将装有南美蟛蜞菊凋落物的尼龙袋加入到不同深度(即0、2、4和6 cm)的砂土、营养土和粘土中,经6个月的分解后,回收凋落物袋并计算分解速率,随后在凋落物分解处理后的土壤中种植本地蟛蜞菊,并在生长期结束时测量其生理生态指标。研究结果表明,所有处理土壤类型中,凋落物在土壤深度为2和4 cm处分解后显著增加了土壤养分,而对本地蟛蜞菊的叶片叶绿素、叶氮含量等生长指标表现为负效应。因此,入侵植物南美蟛蜞菊凋落物分解对土壤养分表现为正的反馈效应,而对本地植物蟛蜞菊的生长表现为负效应。我们的研究结果还表明,入侵植物的凋落物分解对土壤和本地物种的影响还因凋落物分解所在的土壤深度而显著不同。未来的研究应侧重于入侵栖息地中更多本地和入侵物种的植物-土壤反馈效应,以及更多土壤类型和土壤深度的入侵植物凋落物效应。 | Jianfan Sun Susan Rutherford Muhammad Saif Ullah Ikram Ullah Qaiser Javed Ghulam Rasool Muhammad Ajmal Ahmad Azeem Muhammad Junaid Nazir Daolin Du | 2022 | Journal of Plant Ecology2022，15，3： | 2 |
| 19 | The STING 1 network regulates autophagy and cell death显示文摘Cell death and immune response are at the core of life.In past decades,the endoplasmic reticulum(ER)protein STING!(also known as STING or TMEM173)was found to play a fundamental role in the production of type I interferons(IFNs)and pro-inflammatory cytokines in response to DNA derived from invading microbial pathogens or damaged hosts by activating multiple transcription factors.In addition to this well-known function in infection,inflammation,and immunity,emerging evidence suggests that the STING 1-dependent signaling network is implicated in health and disease by regulating autophagic degradation or various cell death modalities(e.g.,apoptosis,necroptosis,pyroptosis,ferroptosis,mitotic cell death,and immunogenic cell death[ICD]).Here,we outline the latest advances in our understanding of the regulating mechanisms and signaling pathways of STING1 in autophagy and cell death,which may shed light on new targets for therapeutic interventions. | Ruoxi Zhang Rui Kang Daolin Tang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 20 | Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat显示文摘 | Daolin Fu Péter Sz?cs Liuling Yan Marcelo Helguera Jeffrey S. Skinner Jarislav von Zitzewitz Patrick M. Hayes Jorge Dubcovsky | 2005 | Molecular Genetics and Genomics2005，，1： | 2 |
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