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4篇 您的检索式：作者名="Danting Su"

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		题名	作者	年代	出处	被引量
	1	PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma显示文摘ERK pathway regulated the programmed death ligand-1(PD-L1)expression which was linked to the response of programmed death-1(PD-1)/PD-L1 blockade therapy.So it is deducible that ERK inhibitor could enhance the efficacy of PD-1 inhibitor in cancer immunotherapy.In this study,PD0325901,an oral potent ERK inhibitor,strongly enhanced the efficacy of PD-1 antibody in vitro and in vivo models in non-small cell lung carcinoma(NSCLC)cells.Mechanistically,PD0325901 or shRNA-ERK1/2 significantly downregulated the PD-L1 expression in NSCLC cells and increased the CD3+T cells infiltration and functions in tumor tissue.There was a positive correlation between the p-ERK1/2 expression and PD-L1 expression in patients with NSCLC.And the patients with low p-ERK1/2 expression were observed a high response rate of PD-1/PD-L1 blockage therapy.Our results demonstrate that PD0325901,an ERK inhibitor,can enhance the efficacy of PD-1 blockage against NSCLC in vitro and in vivo models.And the combination of ERK inhibitor such as PD0325901 and PD-1/PD-L1 blockage is a promising regimen and encouraged to be further confirmed in the treatment of patients with NSCLC.	Min Luo Yuhui Xia Fang Wang Hong Zhang Danting Su Chaoyue Su Chuan Yang Shaocong Wu Sainan An Suxia Lin Liwu Fu	2021	Acta Pharmaceutica Sinica B2021，11，10：	1
	2	Fine mapping of S32(t), a new gene causing hybrid embryo sac sterility in a Chinese landrace rice (Oryza sativa L.)显示文摘	Danting Li Liangming Chen Ling Jiang Susong Zhu Zhigang Zhao Shijia Liu Ning Su Huqu Zhai Hiroshi Ikehashi Jianmin Wan	2007	Theoretical and Applied Genetics2007，，3：	1
	3	Immune responses induced by DNA vaccines bearing Spike gene of PEDV combined with porcine IL-18显示文摘	Siqingaowa Suo Yudong Ren Guangxing Li Dante Zarlenga Ri-e Bu Dingding Su Xunliang Li Pengchong Li Fandan Meng Chao Wang Xiaofeng Ren	2012	Virus Research2012，，2：	1
	4	RuxCrySex electrocatalyst for oxygen reduction in a polymer electrolyte membrane fuel cell 显示文摘	Su'arez-Alc'antara K Rodr'y'guez-Castellanos Dante A R	2006	J Power Sources2006，，157：	1

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