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| 1 | Cross-talk between NMDA and GABA_A receptors in cultured neurons of the rat inferior colliculus显示文摘Neuronal ion channels of different types often do not function independently but will inhibit or potentiate the activity of other types of channels,a process called cross-talk.The N-methyl-D-aspartate receptor (NMDA receptor) and the γ-aminobutyric acid type A receptor (GABAA receptor) are important excitatory and inhibitory receptors in the central nervous system,respectively.Currently,cross-talk between the NMDA receptor and the GABAA receptor,particularly in the central auditory system,is not well understood.In the present study,we investigated functional interactions between the NMDA receptor and the GABAA receptor using whole-cell patch-clamp techniques in cultured neurons from the inferior colliculus,which is an important nucleus in the central auditory system.We found that the currents induced by aspartate at 100 μmol L-1 were suppressed by the pre-perfusion of GABA at 100 μmol L-1,indicating cross-inhibition of NMDA receptors by activation of GABAA receptors.Moreover,we found that the currents induced by GABA at 100 μmol L-1 (IGABA) were not suppressed by the pre-perfusion of 100 μmol L-1 aspartate,but those induced by GABA at 3 μmol L-1 were suppressed,indicating concentration-dependent cross-inhibition of GABAA receptors by activation of NMDA receptors.In addition,inhibition of IGABA by aspartate was not affected by blockade of voltage-dependent Ca2+ channels with CdCl2 in a solution that contained Ca2+,however,CdCl2 effectively attenuated the inhibition of IGABA by aspartate when it was perfused in a solution that contained Ba2+ instead of Ca2+ or a solution that contained Ca2+ and 10 mmol L-1 BAPTA,a membrane-permeable Ca2+ chelator,suggesting that this inhibition is mediated by Ca2+ influx through NMDA receptors,rather than voltage-dependent Ca2+ channels.Finally,KN-62,a potent inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII),reduced the inhibition of IGABA by aspartate,indicating the involvement of CaMKII in this cross-inhibition.Our study demonstrates a functional interaction between NMDA and GABAA receptors in the inferior colliculus of rats.The presence of cross-talk between these receptors suggests that the mechanisms underlying information processing in the central auditory system may be more complex than previously believed. | CONG DanNi TANG ZhengQuan LI LongZhu HUANG YiNa WANG Jun CHEN Lin | 2011 | Science China(Life Sciences)2011，54，6： | 9 |
| 2 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 3 | Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration显示文摘The design of orthopedic biomaterials has gradually shifted from“immune-friendly”to“immunomodulatory,”in which the biomaterials are able to modulate the inflammatory response via macrophage polarization in a local immune microenvironment that favors osteogenesis and implant-to-bone osseointegration.Despite the well-known effects of bioactive metallic ions on osteogenesis,how extracellular metallic ions manipulate immune cells in bone tissue microenvironments toward osteogenesis and subsequent bone formation has rarely been studied.Herein,we investigate the osteoimmunomodulatory effect of an extracellular bioactive cation(Mg^(2+))in the bone tissue microenvironment using custom-made poly lactic-co-glycolic acid(PLGA)/MgO-alendronate microspheres that endow controllable release of magnesium ions.The results suggest that the Mg^(2+)-controlled tissue microenvironment can effectively induce macrophage polarization from the M0 to M2 phenotype via the enhancement of anti-inflammatory(IL-10)and pro-osteogenic(BMP-2 and TGF-β1)cytokines production.It also generates a favorable osteoimmune microenvironment that facilitates the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells.The in vivo results further verify that a large amount of bony tissue,with comparable bone mineral density and mechanical properties,has been generated at an early post-surgical stage in rat intramedullary bone defect models.This study demonstrates that the concept of in situ immunomodulated osteogenesis can be realized in a controlled magnesium tissue microenvironment. | Zhengjie Lin Danni Shen Weixiao Zhou Yufeng Zheng Tiantian Kong Xuanyong Liu Shuilin Wu Paul K.Chu Ying Zhao Jun Wu Kenneth M.C.Cheung Kelvin W.K.Yeung | 2021 | Bioactive Materials2021，6，8： | 5 |
| 4 | Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation,migration,and invasion of thyroid cancer cells via Hippo pathway显示文摘In recent decades,the incidence of thyroid cancer(TC)has rapidly increased,leading us to explore the complex underlying mechanisms.We identified the gene Phospholipase C Delta 3(PLCD3)as a potential oncogene in TC by conducting the whole transcriptome sequencing.Our study is to understand the oncogenic role of PLCD3 in TC.We verified the overexpression of PLCD3 in TC from The Cancer Genome Atlas,Gene Expression Omnibus databases,and a locally validated cohort.Clinical correlation analysis showed that PLCD3 expression was related to histological type,T stage,lymph node metastasis(LNM),and disease stage.The high expression of PLCD3 could be a distinguishing factor for TC and its LNM.The biological function was examined using small interfering RNA-transfected TC cell lines.Silenced PLCD3 could inhibit colony formation,migration,and invasion ability and promote apoptosis of TC cell lines.PLCD3 silencing reversed the epithelial-mesenchymal transition but induced the apoptotic progress.Further exploration revealed that PLCD3 might be associated with critical genes of the Hippo pathway.The expressions of RHOA,YAP1/TAZ,and their downstream targets were decreased significantly when PLCD3 was down-regulated.YAP1 overexpression rescued the tumor-suppressive effect caused by PLCD3 silencing.This study demonstrates that PLCD3 is an oncogene that supports tumorigenesis and progression in TC,and PLCD3 may be a potential target gene for TC treatment. | Lizhi Lin Jialiang Wen Bangyi Lin Hao Chen Adheesh Bhandari Yufeng Qi Danni Zheng Ouchen Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 4 |
| 5 | Congenital bifurcation of tympanic segment of facial nerve显示文摘Congenital aural atresia is usually associated with facial nerve (the seventh cranial nerve,CN7) anomalies with an incidence rate of 60%-75%.These anomalies include facial nerve displacement,facial nerve component overlying the oval window,bony canal dehiscence,and bifurcation,which increase the risk of surgical facial nerve injuries.Among all these anomalies,congenital bifurcation of the tympanic segment of facial nerve is the most confusing situation that significantly increases the surgical risk during hearing reconstruction. | Wang Danni Zhao Shouqin Zhao Yanling Chen Shubin Yang Lin | 2014 | Chinese Medical Journal2014，，9： | 3 |
| 6 | Magnetic resonance (MR) safety and compatibility of a novel iron bioresorbable scaffold显示文摘Fully bioresorbable scaffolds have been designed to overcome the limitations of traditional drug-eluting stents(DESs),which permanently cage the native vessel wall and pose possible complications.The ultrathin-strut designed sirolimus-eluting iron bioresorbable coronary scaffold system(IBS)shows comparable mechanical properties to traditional DESs and exhibits an adaptive degradation profile during target vessel healing,which makes it a promising candidate in all-comers patient population.For implanted medical devices,magnetic resonance(MR)imaging properties,including MR safety and compatibility,should be evaluated before its clinical use,especially for devices with intrinsic ferromagnetism.In this study,MR safety and compatibility of the IBS scaffold were evaluated based on a series of well-designed in-vitro,ex-vivo and in-vivo experiments,considering possible risks,including scaffold movement,over-heating,image artifact,and possible vessel injury,under typical MR condition.Traditional ASTM standards for MR safety and compatibility evaluation of intravascular devices were referred,but not only limited to that.The unique time-relevant MR properties of bioresorbable scaffolds were also discussed.Possible forces imposed on the scaffold during MR scanning and MR image artifacts gradually decreased along with scaffold degradation/absorption.Rigorous experiments designed based on a scientifically based rationale revealed that the IBS scaffold is MR conditional,though not MR compatible before complete absorption.The methodology used in the present study can give insight into the MR evaluation of magnetic scaffolds(bioresorbable)or stents(permanent). | Dong Bian Li Qin Wenjiao Lin Danni Shen Haiping Qi Xiaoli Shi Gui Zhang Hongwei Liu Han Yang Jin Wang Deyuan Zhang Yufeng Zheng | 2020 | Bioactive Materials2020，5，2： | 2 |
| 7 | Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study显示文摘 | Xian-Feng Lin Ke-Qing Shi Jie You Wen-Yue Liu Ying-Wan Luo Fa-Ling Wu Yong-Ping Chen Danny Ka-Ho Wong Man-Fung Yuen Ming-Hua Zheng | 2014 | Molecular Biology Reports2014，，5： | 1 |
| 8 | Food Availability,Enti-tlements and the Chinese Famine of 1959-61显示文摘 | | 2000 | The Eco-nomic Journal2000，，： | 1 |
| 9 | Misdiagnosis of neck sinus infection in congenital external auditory canal stenosis with cholesteatoma显示文摘 | Yang Lin Zhao Shouqin Liu Zhonglin Wang Danni Ren Ran | 2014 | Chinese Medical Journal2014，，13： | 1 |
| 10 | Network Curriculum Design of Traditional Chinese Medicine Pharmacy Specialty Formed by Introducing Guangxi Minority Medicine显示文摘Starting from the background and significance of the development and design of the network course of traditional Chinese medicine pharmacy specialty formed by introducing Guangxi minority medicine,this paper discusses the teaching design scheme and module construction of the network course in the development process,and summarizes the design,production and construction experience of the network course.Through practice,the teaching effect and achievement of the network course of traditional Chinese medicine pharmacy specialty formed by introducing Guangxi minority medicine are obvious. | Anda WEI Hua ZHU Liqun SHEN Lin KANG Fengfeng XIE Danni LI | 2022 | Medicinal Plant2022，13，2： | 1 |
| 11 | Atomically Dispersed Fe-N_4 Modified with Precisely Located S for Highly Efficient Oxygen Reduction显示文摘Immobilizing metal atoms by multiple nitrogen atoms has triggered exceptional catalytic activity toward many critical electrochemical reactions due to their merits of highly unsaturated coordination and strong metal-substrate interaction.Herein,atomically dispersed Fe-NC material with precise sulfur modification to Fe periphery(termed as Fe-NSC) was synthesized,X-ray absorption near edge structure analysis confirmed the central Fe atom being stabilized in a specific configuration of Fe(N3)(N-C-S).By enabling precisely localized S doping,the electronic structure of Fe-N4 moiety could be mediated,leading to the beneficial adjustment of absorption/desorption properties of reactant/intermediate on Fe center.Density functional theory simulation suggested that more negative charge density would be localized over Fe-N4 moiety after S doping,allowing weakened binding capability to *OH intermediates and faster charge transfer from Fe center to O species.Electrochemical measurements revealed that the Fe-NSC sample exhibited significantly enhanced oxygen reduction reaction performance compared to the S-free Fe-NC material(termed as Fe-NC),showing an excellent onset potential of 1.09 V and half-wave potential of 0.92 V in 0.1 M KOH.Our work may enlighten relevant studies regarding to accessing improvement on the catalytic performance of atomically dispersed M-NC materials by managing precisely tuned local environments of M-Nx moiety. | Yin Jia Xuya Xiong Danni Wang Xinxuan Duan Kai Sun Yajie Li Lirong Zheng Wenfeng Lin Mingdong Dong Guoxin Zhang Wen Liu Xiaoming Sun | 2020 | Nano-Micro Letters2020，12，9： | 1 |
| 12 | Custom-contoured ablation pattern method for the treatment of decentered laser ablations显示文摘 | Danny Y Lin Edward E Manche | 2004 | Journal of Cataract & Refractive Surgery2004，，8： | 1 |
| 13 | The Impacts of Country-of-Origin on Brand Equity显示文摘 | Danny T Kao | 2004 | Journal of American Academy of Business Sep2004，5，： | 1 |
| 14 | Herbal formula FBD extracts prevented brain injury and inflammation induced by cerebral ischemia-reperfusion显示文摘 | Zhihong Lin Danni Zhu Yongqing Yan | | 0，，： | 1 |
| 15 | The Impacts of Country -of-Origin on Brand Equity显示文摘 | Chien-Huang Lin Danny T Kao | 2004 | Journal of American Academy of Business Cambridge2004，9，5： | 1 |
| 16 | Protective effects of FBD-an experimental Chinese traditional medic- inal formula on memory dysfunction in mice induced by cerebral ischemia-reperfusion 显示文摘 | Zhihong Lin Yongqing Yan Danni Zhu | 2005 | Journal of Ethnophar-rnacology2005，97，： | 1 |
| 17 | Herbal formula FBD extracts prevented brain injury and inflammation induced by cerebral ischemia-reperfusion 显示文摘 | Lin Zhihong Zhu Danni Yan Yongqing | 2008 | J Ethnopharmacol2008，118，1： | 1 |
| 18 | Characterization of homoisoflavonoidsin different cultivation regions of Ophiopogon japonicusand related antioxidant activity显示文摘 | Yining Lin Danni Zhu Jin Qi | 2010 | J Pharm BiomedAnal2010，52，： | 1 |
| 19 | The Development of Nietzsche’s Aesthetics显示文摘Aesthetics is an important part of F.Nietzsche’s ideological system.This paper is based on Nietzsche’s experience and masterpieces of different periods,reviewing the changes of his aesthetic idea,in order to grasp the development of Nietzsche’s Aesthetic theory,then we found that Nietzsche’s Aesthetics has a close relationship with the life,practice and politics. | LIN Danni | 2019 | Journal of Literature and Art Studies2019，9，1： | 0 |
| 20 | Research and Practice on Curriculum Reform of Chinese Pharmaceutical Manufacturing Major against the Backdrop of'Comprehensive Health'显示文摘Against the backdrop of Comprehensive Health,the Chinese Pharmaceutical Manufacturing major faces both opportunities and challenges.This paper describes some problems encountered in the development of the Chinese Pharmaceutical Manufacturing major,puts forward some suggestions and measures to adapt to the training of talents of Chinese pharmaceutical manufacturing against the backdrop of Comprehensive Health,and discusses the practical research on curriculum reform. | Hua ZHU Liqun SHEN Anda WEI Lin KANG Fengfeng XIE Danni LI | 2022 | Asian Agricultural Research2022，14，4： | 0 |
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