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您的检索式：作者名="Bangyi Lin"
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| 1 | Phospholipase C Delta 3 inhibits apoptosis and promotes proliferation,migration,and invasion of thyroid cancer cells via Hippo pathway显示文摘In recent decades,the incidence of thyroid cancer(TC)has rapidly increased,leading us to explore the complex underlying mechanisms.We identified the gene Phospholipase C Delta 3(PLCD3)as a potential oncogene in TC by conducting the whole transcriptome sequencing.Our study is to understand the oncogenic role of PLCD3 in TC.We verified the overexpression of PLCD3 in TC from The Cancer Genome Atlas,Gene Expression Omnibus databases,and a locally validated cohort.Clinical correlation analysis showed that PLCD3 expression was related to histological type,T stage,lymph node metastasis(LNM),and disease stage.The high expression of PLCD3 could be a distinguishing factor for TC and its LNM.The biological function was examined using small interfering RNA-transfected TC cell lines.Silenced PLCD3 could inhibit colony formation,migration,and invasion ability and promote apoptosis of TC cell lines.PLCD3 silencing reversed the epithelial-mesenchymal transition but induced the apoptotic progress.Further exploration revealed that PLCD3 might be associated with critical genes of the Hippo pathway.The expressions of RHOA,YAP1/TAZ,and their downstream targets were decreased significantly when PLCD3 was down-regulated.YAP1 overexpression rescued the tumor-suppressive effect caused by PLCD3 silencing.This study demonstrates that PLCD3 is an oncogene that supports tumorigenesis and progression in TC,and PLCD3 may be a potential target gene for TC treatment. | Lizhi Lin Jialiang Wen Bangyi Lin Hao Chen Adheesh Bhandari Yufeng Qi Danni Zheng Ouchen Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 4 |
| 2 | The proportions and variations of the light absorption coefficients of major ocean color components in the East China Sea显示文摘The East China Sea (ECS),one of the largest continental seas,has dynamic hydrology and complex optical characteristics that make ocean color remote-sensing retrieval difficult.The distributions and proportions of the light absorption coefficients of major ocean color components based on two large-scale investigations in the ECS are presented,showing these features in typical summer and winter seasons.The absorption coefficient a CDOM,a NAP and a phy of colored dissolved organic matter,non-algal particle,and pigment of phytoplankton show a decreasing trend from the coast to the outer shelf.According to the a CDOM distribution at 440 nm,the Changjiang River plume shows an abnormal southeastward transport.An extremely high a NAP value patch at 440 nm is present in the middle coast.The chlorophyll-a-specific phytoplankton pigment absorption (a phy) is much higher in winter than in summer,which may cause serious underestimated results when applying the averaged a phy into remote-sensing algorithms for chlorophyll concentration retrieval.The importance of phytoplankton size was evident in outer shelf waters.The absorption of a CDOM (440) is a dominant component accounting for over half of the total seawater absorption in summer.The a NAP (440) accounts for 64% of the absorption of the ECS coastal area in winter. | LEI Hui PAN Delu BAI Yan TAO Bangyi SUN Jun ZHANG Lin ZHANG Xuan | 2012 | Acta Oceanologica Sinica2012，31，2： | 3 |
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