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| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Constructing Straight Pores and Improving Mechanical Properties of GangueBased Porous Ceramics显示文摘The large-scale accumulation and pollution of solid mining waste is an urgent issue.Coal gangue is a prominent type of solid waste,and shows promise for use in high value-added products due to its content of many important compounds,including SiO_(2) and Al2O3.This study proposed the preparation of highly porous ceramics from coal gangue,coal slime,and coconut palm fibers.The ceramics were produced at a sintering temperature of 950℃ with a fiber content of 6 wt%,which led to the formation of porous ceramics with a porosity of 66.93%,volume density of 1.0329 g/cm^(3),compressive strength of 1.1025 MPa,and thermal conductivity is 0.3919 K(W/mk).A finite element model of the porous ceramics was established using the Abaqus module in ANSYS software,where the stress distribution and compressive strength were simulated.Further,the relationship between porosity and compressive strength was analyzed.The thermal properties of the porous ceramics were analyzed using the Fluent module,where the simulated changes in porosity under various sintering temperatures were consistent with the experimental data.The preparation of this highly porous ceramic from solid waste coal gangue shows promise for the minimizing the impact of waste gas and wastewater pollution in the future. | Hang Xu Huiling Du Le Kang Qiudi Cheng Danni Feng Siyu Xia | 2021 | Journal of Renewable Materials2021，9，12： | 4 |
| 3 | Removal of trimethoprim and sulfamethoxazole in artificial composite soil treatment systems and diversity of microbial communities显示文摘Four artificial composite soil treatment systems(ACSTs)fed with reclaimed water containing trimethoprim(TMP)and sulfamethoxazole(SMX)were constructed to investigate SMX and TMP biodegradation efficiency,ammonia and nitrite removal conditions and the microbial community within ACST layers.Results showed SMX and TMP removal rates could reach 80% and 95%,respectively,and removal rates of ammonia and nitrite could reach 80% and 90%,respectively,in ACSTs.The MiSeq sequencing results showed that microbial community structures of the ACSTs were similar.The dominant microbial community in the adsorption and biodegradation layers of the ACSTs contained Proteobacteria,Chloroflexi,Acidobacteria,Firmicutes,Actinobacteria and Nitrospirae.Firmicutes and Proteobacteria were considerably dominant in the ACST biodegradation layers.The entire experimental results indicated that Nitrosomonadaceae_uncultured,Nitrospira and Bacillus were associated with nitrification processes,while Bacillus and Lactococcus were associated with SMX and TMP removal processes.The findings suggest that ACSTs are appropriate for engineering applications. | Qinqin Liu Miao Li Rui Liu Quan Zhang Di Wu Danni Zhu Xuhui Shen Chuanping Feng Fawang Zhang Xiang Liu | 2019 | Frontiers of Environmental Science & Engineering2019，13，2： | 2 |
| 4 | Model based ISAR ship classification显示文摘 | FENG R TRISTROM C DANNY G | 2006 | Digital Signal Processing2006，，16： | 1 |
| 5 | Identification of Q-Markers from Hedan Tablet by employing “spiderweb”mode and taking compounds'hepatotoxicity into account显示文摘Objective Due to the complicated compounds and the synergistic effect of multi-compounds,the quality control and assessment of Chinese materia medica(CMM)encounters a great challenge about how to identify the key compounds,which are directly correlated with its efficacy and safety.On the guidance of study on quality marker(Q-Marker),identification of Q-Markers was performed from Hedan Tablet(HDT)by the aid of the“spider-web”mode and hepatotoxicity evaluation derived from our previous researches and literatures.Methods By the established ultra performance liquid chromatography with photodiode array detector(UPLC-PDA)method,online UPLC-DPPH·and offline antioxidant assay,21 candidate compounds of HDT were systematically investigated and comprehensively evaluated by the“spider-web”mode for them properties of Q-Marker based on“content-stability-activity”.In addition,the Q-Markers related with hepatotoxicity based on our previous researches and literatures were identified.Results Salvianolic acid B(SaB),quercetin-3-O-glucuronide(Qug),isoquercitrin(IQ)and hyperoside(Hyp)were adopted as the preferable Q-Markers of HDT according to the shaded area(A)of tested compounds in“spider-web”mode.Psoralen(Ps),isopsoralen(IP),psoralenoside(PO)and isopsoralenoside(IPO)were also strongly recommended as Q-Markers closely related with safety by considering hepatotoxicity of the accumulated Ps and IP and conversion between glycoside(PO and IPO)and aglycone(Ps and IP).Conclusion This study provided scientific evidence for quality control and assessment of HDT,and also provided a meaningful reference for application of Q-Markers in CMM. | Danni Wang Jiamin Ding Xiafei Feng Xin Chai Jing Yang Chunlei Liu Yingzi Zeng Wanhui Zhou Yuefei Wang | 2022 | Chinese Herbal Medicines2022，14，4： | 1 |
| 6 | Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies显示文摘The global market demand for natural astaxanthin is rapidly increasing owing to its safety,the potential health benefits,and the diverse applications in food and pharmaceutical industries.The major native producers of natural astaxanthin on industrial scale are the alga Haematococcus pluvialis and the yeast Xanthopyllomyces dendrorhous.However,the natural production via these native producers is facing challenges of limited yield and high cost of cultivation and extraction.Alternatively,astaxanthin production via metabolically engineered non-native microbial cell factories such as Escherichia coli,Saccharomyces cerevisiae and Yarrowia lipolytica is another promising strategy to overcome these limitations.In this review we summarize the recent scientific and biotechnological progresses on astaxanthin biosynthetic pathways,transcriptional regulations,the interrelation with lipid metabolism,engineering strategies as well as fermentation process control in major native and non-native astaxanthin producers.These progresses illuminate the prospects of producing astaxanthin by microbial cell factories on industrial scale. | Mostafa Basiony Liming Ouyang Danni Wang Jiaming Yu Liming Zhou Mohan Zhu Xuyuan Wang Jie Feng Jing Dai Yijie Shen Chengguo Zhang Qiang Hua Xiuliang Yang Lixin Zhang | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 1 |
| 7 | Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells显示文摘 | Hong Tao Haiying Li Yanhuang Su Danni Feng Xilong Wang Chun Zhang Hui Ma Qikuan Hu | 2014 | Molecular and Cellular Biochemistry . 2014 (1-2)2014，，1： | 1 |
| 8 | New insights into the formation of ammonium nitrate from a physical and chemical level perspective显示文摘High levels of fine particulate matter(PM_(2.5))is linked to poor air quality and premature deaths,so haze pollution deserves the attention of the world.As abundant inorganic components in PM_(2.5),ammonium nitrate(NH_(4)NO_(3))formation includes two processes,the diffusion process(molecule of ammonia and nitric acid move from gas phase to liquid phase)and the ionization process(subsequent dissociation to form ions).In this study,we discuss the impact of meteorological factors,emission sources,and gaseous precursors on NH4NO3 formation based on thermodynamic theory,and identify the dominant factors during clean periods and haze periods.Results show that aerosol liquid water content has a more significant effect on ammonium nitrate formation regardless of the severity of pollution.The dust source is dominant emission source in clean periods;while a combination of coal combustion and vehicle exhaust sources is more important in haze periods.And the control of ammonia emission is more effective in reducing the formation of ammonium nitrate.The findings of this work inform the design of effective strategies to control particulate matter pollution. | Yuting Wei Xiao Tian Junbo Huang Zaihua Wang Bo Huang Jinxing Liu Jie Gao Danni Liang Haofei Yu Yinchang Feng Guoliang Shi | 2023 | Frontiers of Environmental Science & Engineering2023，17，11： | 0 |
| 9 | CHALLENGES AND CAPACITY GAPS IN SMALLHOLDER ACCESS TO DIGITAL EXTENSION AND ADVISORY SERVICES IN KENYA AND UGANDA显示文摘An assessment of the challenges and capacity gaps in smallholder access to digital extension and advisory services(EAS)was made by surveying 197 female and 239 male farmers in Kenya and Uganda.Non-digital extension approaches remain dominant but at least 78%of farmers accessed EAS from electronic sources dominated by radio.This is attributed to the fact that ownership of radios was more widespread than of other digital devices.Challenges that particularly limit the use of digital services included low digital literacy and prohibitive cost of internet and mobile devices.Female and elderly farmers were more likely to report these challenges than their counterparts.Logistic regression model results show that ownership of digital devices,participation in post-production activities,and access to extension were enablers of digital EAS use.Farmers mentioned gaps in obtaining information on crop pest/disease diagnosis and management,fertilizer application,pesticide safety and quality seed.Given the diversity in smallholder technological capabilities and information needs,the recommendations made include integration of digital communication within multimode advisory services that use different but linked communication channels,continued farmer digital innovation capacity enhancement,and participatory design approaches that deliver relevant and actionable information for inclusive scaling of extension activities. | Monica K.KANSIIME Idah MUGAMBI Harrison RWARE Christine ALOKIT Caroline ALIAMO Feng ZHANG Jakob LATZKO Puyun YANG Daniel KARANJA Dannie ROMNEY | 2022 | Frontiers of Agricultural Science and Engineering2022，9，4： | 0 |
| 10 | Single-phase formation mechanism and dielectric properties of sol-gel-derived Ba(Ti_(0.2)Zr_(0.2)Sn_(0.2)Hf_(0.2)Ce_(0.2))O_(3) high-entropy ceramics显示文摘Single-phase Ba(Ti_(0.2)Zr_(0.2)Sn_(0.2)Hf_(0.2)Ce_(0.2))O_(3)(BTZSHC) high-entropy ceramics(HECs) with the perovskite structure were successfully prepared via the sol-gel method.The results reveal that the as-prepared ceramics exhibit a single cubic phase belonging to the Pm3 m space group.The high entropy is the driving force of the formation of single-phase ceramics.A larger entropy(ΔS_(mix)) and a negative enthalpy(ΔH_(mix)) are conducive to the formation of single-phase compounds.Herein,ΔS_(mix)=0.323 R mole-1andΔH_(mix)=43.88 kJ/mol.The sluggish-diffusion effect ensures the thermal stability of high-entropy systems.Dielectric measurements reveal that the as-prepared BTZSHC high-entropy ceramics are relaxor ferroelectrics,and the degree of relaxor(γ) is 1.9.The relaxor behavior of the as-prepared ceramics can be ascribed to the relaxation and thermal evolution of their polar units(PUs).The findings of this work provide a theoretical basis and technical support for the preparation of single-phase high-entropy ceramics. | Jia Liu Cuiying Ma Lianli Wang Ke Ren Hongpei Ran Danni Feng Huiling Du Yiguang Wang | 2022 | Journal of Materials Science & Technology2022，，35： | 0 |
| 11 | In-situ growth of low-dimensional perovskite-based insular nanocrystals for highly efficient light emitting diodes显示文摘Regulation of perovskite growth plays a critical role in the development of high-performance optoelectronic devices.However,judicious control of the grain growth for perovskite light emitting diodes is elusive due to its multiple requirements in terms of morphology,composition,and defect.Herein,we demonstrate a supramolecular dynamic coordination strategy to regulate perovskite crystallization.The combined use of crown ether and sodium trifluoroacetate can coordinate with A site and B site cations in ABX_(3) perovskite,respectively.The formation of supramolecular structure retard perovskite nucleation,while the transformation of supramolecular intermediate structure enables the release of components for slow perovskite growth.This judicious control enables a segmented growth,inducing the growth of insular nanocrystal consist of low-dimensional structure.Light emitting diode based on this perovskite film eventually brings a peak external quantum efficiency up to 23.9%,ranking among the highest efficiency achieved.The homogeneous nano-island structure also enables high-efficiency large area(1 cm^(2))device up to 21.6%,and a record high value of 13.6%for highly semi-transparent ones. | Hao Wang Weidong Xu Qi Wei Si Peng Yuequn Shang Xianyuan Jiang Danni Yu Kai Wang Ruihua Pu Chenxi Zhao Zihao Zang Hansheng Li Yile Zhang Ting Pan Zijian Peng Xiaoqin Shen Shengjie Ling Weimin Liu Feng Gao Zhijun Ning | 2023 | Light(Science & Applications)2023，12，3： | 0 |
| 12 | Fungal diversity notes 1151-1276:taxonomic and phylogenetic contributions on genera and species of fungal taxa显示文摘Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa worldwide.This article is the 11th contribution to the fungal diversity notes series,in which 126 taxa distributed in two phyla,six classes,24 orders and 55 families are described and illustrated.Taxa in this study were mainly collected from Italy by Erio Camporesi and also collected from China,India and Thailand,as well as in some other European,North American and South American countries.Taxa described in the present study include two new families,12 new genera,82 new species,five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual reports.The two new families are Eriomycetaceae(Dothideomycetes,family incertae sedis)and Fasciatisporaceae(Xylariales,Sordariomycetes).The twelve new genera comprise Bhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),Eriocamporesia(Cryphonectriaceae),Eriomyces(Eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae,genus incertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae)and Xenoanthostomella(Xylariales,genera incertae sedis).The 82 new species comprise Acremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispora,Cytospora rosigena,Diaporthe camporesii,Diaporthe nigra,Diatrypella yunnanensis,Dictyosporium muriformis,Didymella camporesii,Diutina bernali,Diutina sipiczkii,Eriocamporesia aurantia,Eriomyces heveae,Ernakulamia tanakae,Falciformispora uttaraditensis,Fasciatispora cocoes,Foliophoma camporesii,Fuscostagonospora camporesii,Helvella subtinta,Kalmusia erioi,Keissleriella camporesiana,Keissleriella camporesii,Lanspora cylindrospora,Loratospora arezzoensis,Mariannaea atlantica,Melanographium phoenicis,Montagnula camporesii,Neodidymelliopsis camporesii,Neokalmusia kunmingensis,Neoleptosporella camporesiana,Neomonodictys muriformis,Neomyrmecridium guizhouense,Neosetophoma camporesii,Paraloratospora camporesii,Paramonodictys solitarius,Periconia palmicola,Plenodomus triseptatus,Pseudocamarosporium camporesii,Pseudocercospora maetaengensis,Pseudochaetosphaeronema kunmingense,Pseudoconlarium punctiforme,Pseudodactylaria camporesiana,Pseudomurilentithecium camporesii,Pseudotetraploa rajmachiensis,Pseudotruncatella camporesii,Rhexocercosporidium senecionis,Rhytidhysteron camporesii,Rhytidhysteron erioi,Septoriella camporesii,Setoapiospora thailandica,Srinivasanomyces kangrensis,Tetraploa dwibahubeeja,Tetraploa pseudoaristata,Tetraploa thrayabahubeeja,Torula camporesii,Tremateia camporesii,Tremateia lamiacearum,Uzbekistanica pruni,Verruconis mangrovei,Wilcoxina verruculosa,Xenoanthostomella chromolaenae and Xenodidymella camporesii.The five new combinations are Camporesiomyces patagoniensis,Camporesiomyces vaccinia,Camposporium lycopodiellae,Paraloratospora gahniae and Rhexocercosporidium microsporum.The 22 new records on host and geographical distribution comprise Arthrinium marii,Ascochyta medicaginicola,Ascochyta pisi,Astrocystis bambusicola,Camposporium pellucidum,Dendryphiella phitsanulokensis,Diaporthe foeniculina,Didymella macrostoma,Diplodia mutila,Diplodia seriata,Heterosphaeria patella,Hysterobrevium constrictum,Neodidymelliopsis ranunculi,Neovaginatispora fuckelii,Nothophoma quercina,Occultibambusa bambusae,Phaeosphaeria chinensis,Pseudopestalotiopsis theae,Pyxine berteriana,Tetraploa sasicola,Torula gaodangensis and Wojnowiciella dactylidis.In addition,the sexual morphs of Dissoconium eucalypti and Phaeosphaeriopsis pseudoagavacearum are reported from Laurus nobilis and Yucca gloriosa in Italy,respectively.The holomorph of Diaporthe cynaroidis is also reported for the first time. | Kevin DHyde Yang Dong Rungtiwa Phookamsak Rajesh Jeewon DJayarama Bhat EBGareth Jones Ning‑Guo Liu Pranami DAbeywickrama Ausana Mapook Deping Wei Rekhani HPerera Ishara SManawasinghe Dhandevi Pem Digvijayini Bundhun Anuruddha Karunarathna Anusha HEkanayaka Dan‑Feng Bao Junfu Li Milan CSamarakoon Napalai Chaiwan Chuan‑Gen Lin Kunthida Phutthacharoen Sheng‑Nan Zhang Indunil CSenanayake Ishani DGoonasekara Kasun MThambugala Chayanard Phukhamsakda Danushka STennakoon Hong‑Bo Jiang Jing Yang Ming Zeng Naruemon Huanraluek Jian‑Kui(Jack)Liu Subodini NWijesinghe Qing Tian Saowaluck Tibpromma Rashika SBrahmanage Saranyaphat Boonmee Shi‑Ke Huang Vinodhini Thiyagaraja Yong‑Zhong Lu Ruvishika SJayawardena Wei Dong Er‑Fu Yang Sanjay KSingh Shiv Mohan Singh Shiwali Rana Sneha SLad Garima Anand Bandarupalli Devadatha MNiranjan VVenkateswara Sarma Kare Liimatainen 馻‑ Tuula Niskanen Andy Overall Renato Lúcio Mendes Alvarenga Tatiana Baptista Gibertoni Walter PPfliegler EnikőHorváth Alexandra Imre Amanda Lucia Alves Ana Carla da Silva Santos Patricia Vieira Tiago Timur SBulgakov Dhanushaka NWanasinghe Ali HBahkali Mingkwan Doilom Abdallah MElgorban Sajeewa SNMaharachchikumbura Kunhiraman CRajeshkumar Danny Haelewaters Peter EMortimer Qi Zhao Saisamorn Lumyong Jianchu Xu Jun Sheng | 2020 | Fungal Diversity2020，，1： | 0 |
| 13 | MAFLD was more easily diagnosed than NAFLD in liver transplant recipients with abnormal liver function显示文摘Background and aims:Nonalcoholic fatty liver disease(NAFLD)is hepatic steatosis that is require the exclusion of certain etiologies,including drug usage or alcoholic consumption.Conversely,metabolic dysfunction-associated fatty liver disease(MAFLD)needs not to.In this study,we aimed to examine whether MAFLD is more easily diagnosed than NAFLD in liver transplant(LT)recipients with abnormal liver function.Methods:In this cross-sectional study,LT recipients with abnormal liver function were investigated for the prevalence of MAFLD and NAFLD.Results:We recruited 57 LT recipients with abnormal liver function at a referral hospital.Among these patients,the prevalence of MAFLD and NAFLD was 37.8%and 11.1%,respectively.17 patients showed hepatic steatosis,with an average NAFLD activity score of 3.5 and a fibrosis score of 1.0.Compared with non-MAFLD patients,MAFLD patients had a significant difference in fasting blood glucose levels(p?0.009).Among 17 MAFLD patients,12 were overweight and four were diagnosed with diabetes mellitus.The majority of MAFLD diagnoses were based on body mass index(70.6%)and diabetes mellitus history(23.5%),biomarkers that are easily obtained.At 6,12,24,and 36 months after LT,MAFLD patients had higher levels of fasting blood glucose(6 months:p?0.004,12 months:p?0.038)and higher trend of body mass index value and plasma triglyceride level but no significance.Conclusions:MAFLD was more easily diagnosed in LT recipients with abnormal liver function and higher in prevalence than NAFLD.A larger sample size research is required to validate these conclusions. | Dali Zhang Hongbo Wang Xi He Danni Feng Yanling Sun Zhenwen Liu Yinjie Gao Hongling Liu | 2022 | iLIVER2022，1，3： | 0 |
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