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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic显示文摘AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. | Patrícia Koehler-Santos Patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 3 | Acute heart failure syndromes and coronary perfusion显示文摘 | Beohar N Erdogan AK Daniel CL | 2008 | J Am Coll Cardiol2008，52，1： | 1 |
| 4 | Mucinous colorectal adenocarcinoma: influence of mucin expression (Muc1, 2 and 5) on clinico-pathological features and prognosis显示文摘 | Rodrigo Oliva Perez Bárbara Helou Bresciani Cláudio Bresciani Igor Proscurshim Desiderio Kiss Joaquim Gama-Rodrigues Diego Daniel Pereira Viviane Rawet Ivan Cecconnello Angelita Habr-Gama | 2008 | International Journal of Colorectal Disease2008，，： | 1 |
| 5 | WWOX,the FRA 16 D gene,behsves as a suppressor of turn or growth显示文摘 | Bednarek AK Keck-Waggoner CL Daniel RL | 2001 | cancer Res2001，61，22： | 1 |
| 6 | The CXC chemokine receptor 2,CXCR2,is the putative receptor for ELR+CXC chemokine-induced angiogenic activity 显示文摘 | Addison CL Daniel TO Burdick MD | 2000 | J Immunol2000，165，9： | 1 |
| 7 | Medial support by fibula bone graft in angular stable plate fixation of proximal humeral fractures: an in vitro study with synthetic bone显示文摘 | Georg Osterhoff Daniel Baumgartner Philippe Favre Guido A. Wanner Hans Gerber Hans-Peter Simmen Clément M.L. Werner | 2011 | Journal of Shoulder and Elbow Surgery2011，，5： | 1 |
| 8 | The great potential of the intercostal flap for torso reconstruction显示文摘 | Daniel RK Kerrigan CL Gard DA | 1978 | Plast Reconstr Surg1978，61，5： | 1 |
| 9 | Fetoplacental Oxygenation in an Intrauterine Growth Restriction Rat Model by Using Blood Oxygen Level–Dependent MR Imaging at 4.7 T显示文摘 | Gihad E. Chalouhi Marianne Alison Benjamin Deloison Rokhaya Thiam Gwennhael Autret Daniel Balvay Charles A. Cuenod Olivier Clément Laurent J. Salomon Nathalie Siauve | 2013 | Radiology2013，，1： | 1 |
| 10 | Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young,American Heart Association 显示文摘 | Williams CL Hayman LL Daniels SR | 2002 | Circulation2002，106，1： | 1 |
| 11 | WWOX, the FRA16D Gene, behaves as a Suppressor of-Tumor Growth 显示文摘 | Bednarek AK Keck-Waggoner CL Daniel RL | 2001 | Cancer Res2001，61，22： | 1 |
| 12 | Immunogenicity andreactogenicity of a 13-valent-pneumococcal conjugate vaccineadministered at 2,4,and 12 months of age:a double-blindrandomized active-controlled trial显示文摘 | Snape MD Klinger CL Daniels ED | 2010 | Pediatr Infect Dis J2010，29，12： | 1 |
| 13 | WWOX,the FRA16D gene,behaves as a suppressor of tumor growth 显示文摘 | Bednarek AK Keck-Waggoner CL Daniel RL | 2001 | Cancer Res2001，61，： | 1 |
| 14 | The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity 显示文摘 | Addison CL Daniel TO Burdick MD | 2000 | J Immunol2000，165，9： | 1 |
| 15 | A comparison of glomerular filtra- tion rate estimating equation performance in an older adult popula-tion sample 显示文摘 | Daniel K Cason CL Shrestha S | 2011 | Nephrol Nuts J2011，38，4： | 1 |
| 16 | WWOX, the FRA16D gene, behaves as a suppressor of tumor growth 显示文摘 | Bednarek AK Keck-Waggoner CL Daniel RL | 2001 | Cancer Res2001，61，22： | 1 |
| 17 | WWOX, theFRA16D gene, behaves as a suppressor of tumor growth 显示文摘 | Bednarek AK Keck-Waggoner CL Daniel RL | 2001 | CancerRes2001，61，22： | 1 |
| 18 | The omnipotential pig buttock flap显示文摘 | Daniel RK Kerrigan CL | 1982 | Plast Reconstr Surg1982，70，1： | 1 |
| 19 | The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR + CXC chemokine induced angiogenic activity显示文摘 | Addison CL Daniel TO Burdick MD | 2000 | J Immunol2000，165，9： | 1 |
| 20 | The intercostal flap: an anatomical and hemodynamic approach 显示文摘 | Kerrigan CL Daniel RK | 1979 | Ann Plast Surg1979，2，5： | 1 |
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