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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 3 | Human aminopeptidase N is a receptor for human coronavirus 229E 显示文摘 | Yeager CL Ashmun RA Williams RK | 1992 | Nature1992，357，： | 2 |
| 4 | The effect of short - term withdrawal from continuous positive airway pressure therapy on sym- pathetic activity and markers of vascular inflammation in subjects with obstructive sleep apneea显示文摘 | Phillips CL Yang Q Williams A | 2007 | J Sleep Res2007，16，2： | 1 |
| 5 | Comparison of the effects if Tai Chi and resistance training on bone metabolism in the elderly:a feasibility study显示文摘 | Shen CL Williams JS Chyu MC | | 0，，： | 1 |
| 6 | Muscarinic signaling in carcinoma cells显示文摘 | Williams CL | 2003 | Life Sci2003，72，1819： | 1 |
| 7 | Cytoplasmic calcium modulation and systolic versus diastolic dysfunction in myocardial hypertrophy and failure显示文摘 | Perreault CL Williams CP Morgan SP | 1993 | Circulation1993，，： | 1 |
| 8 | The influence of highcarbohydrate meals with different glycaemic indices on substrate utilisation during subsequent exercise显示文摘 | Wu CL Nicholas C Williams C | 2003 | Br J Nutr2003，90，6： | 1 |
| 9 | Stress -induced changes in intestinal transit in the rat: a model for irritable bowel syndrome显示文摘 | Williams CL Villar RG Peterson JM | 1988 | Gastroenterology1988，94，3： | 1 |
| 10 | Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia显示文摘 | Meck WH Williams CL Cermak JM et a1 | 2007 | Front Integr Neurosci2007，，： | 1 |
| 11 | What spouse caregivers know about communication in Alzheimer's disease:development of the AD Communication Knowledge Test显示文摘 | Williams CL | 2011 | Issues Ment Health Nurs2011，32，1： | 1 |
| 12 | A new recommendation for dietar fiker in childhood显示文摘 | Williams CL Bollella M Mynder EL | 1995 | Pediatrics1995，96，52： | 1 |
| 13 | Mortality associated with congenital syphilis in the united states,1992 ~ 1998显示文摘 | DEBORAH AG WILLIAM CL MICHAEL E | 2002 | Pediatrics2002，109，： | 1 |
| 14 | Cutting edge: influence of Tmevpgl, a long intergenic noncoding RNA, on the expression of Ifng by Thl cells显示文摘 | COLLIER SP COLLINS PL WILLIAMS CL | 2012 | J Immunol2012，189，5： | 1 |
| 15 | Childhood obesity:the health issue 显示文摘 | Deckelbaum RJ Williams CL | 2012 | Obesity2012，9，4： | 1 |
| 16 | Mesenchymal to epithelial transition in development and disease 显示文摘 | Chaffer CL Thompson EW Williams ED | 2007 | Cells Tissues Organs2007，185，13： | 1 |
| 17 | Statin-induced breast cancer cell death:role of inducible nitric oxide and arginase-dependent pathways显示文摘 | Kotamraju S Williams CL Kalyanaraman B | | 0，，07： | 1 |
| 18 | Stress - induced changes in intestinal transit in the rat : a model for irritable bowel syndrome 显示文摘 | Williams CL Villar RG Peterson JM | 1988 | Gastroenterology1988，94，3： | 1 |
| 19 | Development of nurse competencies to improve dementia care显示文摘 | Williams CL Hyer K Kelly A | 2005 | Geriatric Nurs2005，26，2： | 1 |
| 20 | Myocyte-enriched calcineurin-interacting protein,MCIPI,inhibits cardiac hypertrophy in vivo显示文摘 | Rothermel BA McKinsey TA Vega RB Nieol RL Mammen P Yang J Antos CL Shelton JM Bassel-Duby R Olson EN Williams RS | 2001 | Proo Nail Aead Sei U S A2001，98，6： | 1 |
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