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| 1 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 2 | Degradation of Microcystin-RR by Sphingomonas sp. CBA4 isolated from San Roque reservoir (Córdoba – Argentina)显示文摘 | Amé María Valeria Echenique José Ricardo Pflugmacher Stephan Wunderlin Daniel Alberto | 2006 | Biodegradation2006，，5： | 1 |
| 3 | Contrast-en- hanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model显示文摘 | Barry BG Daniel AM Ji-Bin Liu | 2011 | J Ultrasound Med2011，30，： | 1 |
| 4 | Postoperative Pain Facilitates Nonthermoregulatory Tremor显示文摘 | Ernst-Peter Horn Frank Schroeder Stefan Wilhelm Daniel I. Sessler Thomas Standl Katja von dem Busche Jochen Schulte am Esch | 1999 | Anesthesiology1999，，4： | 1 |
| 5 | A new look at nurse burnout: the effects of environmental uncertainty and social climate 显示文摘 | Carrett DK MC Daniel AM | 2001 | J NursAlmin2001，31，2： | 1 |
| 6 | Prospect theory: An analysis of decisian under risk 显示文摘 | Kahneman Daniel Ames Tversky | 1979 | Econometrica1979，47，： | 1 |
| 7 | Role of the opioid system in incentive downshift situations显示文摘 | Daniel AM Ortega LA Papini MR | 2009 | Neurobiol Learn Mem2009，92，3： | 1 |
| 8 | Matrix metalloproteinases in sterile corneal melts 显示文摘 | Geerling G Joussen AM Daniels JT | 1999 | Ann N Y Acad Sci1999，878，： | 1 |
| 9 | New mutes to hyperbranched poly (acrylic acid) surface grafts on polyethylene films and powders 显示文摘 | Bergbreiter DE Danielle BD Kippenberger AM | 2004 | Macromolecules2004，37，23： | 1 |
| 10 | Cyclin D1,p53,MIB1,intratumoral microvessel density,and human papillomavirus in advanced laryngeal carcinoma:association with nodal metastasis显示文摘 | Kumar RV Shenoy AM Daniel R | 2004 | Otolaryngol Head Neck Surg2004，131，4： | 1 |
| 11 | Irreversible telomere shortening by 3′-azido-2′,3′-dideoxythymidine (AZT) treatment显示文摘 | Tejera AM Olive OA | 1998 | Biochem Biophy Res Commun1998，246，1： | 1 |
| 12 | Genetically modified human keratinocytes overexpressing PDGF-A enhance the performance of a composite skin graft显示文摘 | Sabine AE Daniel AM Ronald GT | 1998 | Human Gene Therapy1998，9，： | 1 |
| 13 | Predicting obesity in early adulth-hood from childhood and parental obesity显示文摘 | MAGAREY AM DANIELS LA | 2003 | Int J Obes2003，27，4： | 1 |
| 14 | The emerging role of dairy protein and bioactive peptide in nutrition and health显示文摘 | Richard J F Brain AM Daniel JW | | 0，，04： | 1 |
| 15 | Maternal feeding practices and feeding behaviors of Australian children aged 12 to 36 months 显示文摘 | Chan L Magarey AM Daniels LA | 2011 | Matem Child Health J2011，15，8： | 1 |
| 16 | Prospect Theory:An Analysis of Decision under Risk显示文摘 | Kahneman Daniel Ames Tversky | 1979 | Econometrica1979，47，： | 1 |
| 17 | Prevalence of over-weight and obesity in Australian children and adolescents: reas-international definitions 显示文摘 | Magarey AM Daniels LA Boulton TJ | 2001 | Med J Aust2001，174，： | 1 |
| 18 | The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen显示文摘 | Vincenzi B Daniele S Frezza AM | 2012 | Support Care Cancer2012，20，1： | 1 |
| 19 | Measures of arterial stiffness in youth with type 1 and type 2 diabetes:the SEARCH for diabetes in youth study显示文摘 | Wadwa RP Urbina EM Anderson AM Hamman RF Dolan LM Rodriguez BL Daniels SR Dabelea D | | 0，，： | 1 |
| 20 | Combined colposcopy, loop conization, and laser vaporization reduces recurrent abnormal cytology and residual disease in cervical dysplasia 显示文摘 | Bar - Am A Daniel Y Ron IG | 2000 | Gynecol Oncology2000，78，1： | 1 |
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