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| 1 | Angiographic evaluation and management of acute gastrointestinal hemorrhage显示文摘Although most cases of acute nonvariceal gastrointestinal hemorrhage either spontaneously resolve or respond to medical management or endoscopic treatment,there are still a significant number of patients who require emergency angiography and transcatheter treatment.Evaluation with noninvasive imaging such as nuclear scintigraphy or computed tomography may localize the bleeding source and/or confirm active hemorrhage prior to angiography.Any angiographic evaluation should begin with selective catheterization of the artery supplying the most likely site of bleeding,as determined by the available clinical,endoscopic and imaging data.If a hemorrhage source is identified,superselective catheterization followed by transcatheter microcoil embolization is usually the most effective means of successfully controlling hemorrhage while minimizing potential complications.This is now wellrecognized as a viable and safe alternative to emergency surgery.In selected situations transcatheter intra-arterial infusion of vasopressin may also be useful in controlling acute gastrointestinal bleeding.One must be aware of the various side effects and potential complications associated with this treatment,however,and recognize the high re-bleeding rate.In this article we review the current role of angiography,transcatheter arterial embolization and infusion therapy in the evaluation and management of nonvariceal gastrointestinal hemorrhage. | T Gregory Walker Gloria M Salazar Arthur C Waltman | 2012 | World Journal of Gastroenterology2012，18，11： | 24 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 4 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 5 | New Explanation for the Brightness of Electrodeposits Produced by Ultrasound 显示文摘 | Walker R Walker C T | 1975 | Ultrasonics1975，13，2： | 2 |
| 6 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 7 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 8 | Mitral pseudostenosis due to a large left atrial myxoma显示文摘 | Konstantinos C Theodoropoulos Giovanni Masoero Gianpiero Pagnano Nicola Walker Alexandros Papachristidis Mark J Monaghan | 2018 | Journal of Geriatric Cardiology2018，15，3： | 2 |
| 9 | Ammonia production by ruminal microorganisms and enumeration,isolation,and characterization of bacteria capable of growth on peptides and amino acids from the sheep rumen显示文摘 | Eschenlauer S C McKain N Walker N D | 2002 | Appl Environ Microbiol2002，68，10： | 2 |
| 10 | Testosterone activates mitogen- activated protein kinase and the cAMP responses dement binding protein transcription factor in Sertoli cells 显示文摘 | Fix C Jordan C Cano P Walker WH | 2004 | Proc Natl Acad Sci USA2004，，10： | 1 |
| 11 | Genome-wide expression analysis reveals dysregulation of myelination- related genes in chronic schizophrenia显示文摘 | Hakak Y Walker JR Li C | 2001 | Proc Natl Acad Sci U S A2001，98，8： | 1 |
| 12 | Molecularpanthology and clinical characteristics of oligodondroglialneoplasms显示文摘 | du Plessis DG Joyce KA | 2005 | Ann Neurol2005，57，6： | 1 |
| 13 | RANKL, osteopontin, and osteoclast homeostasis in a hyper - occlusion mouse model 显示文摘 | Walker C Ito Y Dangaria S | 2008 | Eur J Oral Sci2008，116，4： | 1 |
| 14 | Selecting influential busi- ness-to-business customers in new product development: re- lational embeddedness and knowledge heterogeneity eonsid- erations显示文摘 | BONNER M J WALKER C O | 2004 | Product Development and Management Associa- tion2004，21，3： | 1 |
| 15 | Spontaneous intracranial hypotension masquerading as frontotemporal dementia 显示文摘 | Walker L De Meulemeester C | 2008 | Clin Neuropsyehol2008，22，6： | 1 |
| 16 | High speed continuous casting of steel billets Part 2: Mould heat transfer and mould design 显示文摘 | Chow C Samarasekera I V Walker BN etal | 2002 | Ironmaking and Steelmaking2002，29，1： | 1 |
| 17 | Cationic polymerization of emulsified epoxy resins 显示文摘 | Walker F H Dickenson J B Hegedus C R | 2002 | Prog Organ Coat2002，45，23： | 1 |
| 18 | The potential biocontrol agent Pseudomonas antimicrobica inhibits germination of conidia and outgrowth of Botrytis cinerea 显示文摘 | Walker R Innes C Allan E | 2001 | Letters in Applied Microbiology2001，32，： | 1 |
| 19 | Fabrication of a mechanical antireflection switch for fiber-to-thehcme systems 显示文摘 | Walker J A Goossen K W Amey S C | 1996 | J Microelectromech Syst1996，，5： | 1 |
| 20 | Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy显示文摘 | Walker J Martin C Callaghan R | 2002 | Euro J Cancer2002，40，4： | 1 |
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