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| 1 | Toxicity of Graphene Quantum Dots in Zebrafish Embryo显示文摘Objective To evaluate the bio-safety of graphene quantum dots(GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/m L for 4-96 h post-fertilization(hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs(200 μg/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 μg/mL. The larval behavior testing(visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 μg/mL showed hyperactivity while exposure to higher concentrations(25, 50, 100, and 200 μg/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 μg/mL. | WANG Zhen Guo ZHOU Rong JIANG Dan SONG Jing E XU Qian SI Jing CHEN Yun Ping ZHOU Xin GAN Lu LI Jian Zhen ZHANG Hong LIU Bin | 2015 | Biomedical and Environmental Sciences2015，28，5： | 6 |
| 2 | A comparison of surgical efficacy between a 1.8-mm microincision and 3.2-mm and 5.5-mm incisions for phacoemulsification显示文摘Phacoemulsification is a commonly used surgical method in cataract surgery. This paper observes and compares the surgical efficacy of three incisions of different length for phacoemulsification to identify the optimal method for cataract surgery. Ninety patients were enrolled in the present study and divided into three groups. The 1.8-mm group received Bausch & Lomb MI60 foldable intraocular lens(IOL) implantation(n=30), 3.2-mm group received Bausch & Lomb Akreos AO foldable lens implantation(n=30), and 5.5-mm group received Alcon TYPE 05 rigid IOL implantation(n=30). Visual acuity, Oculyzer-based anterior segment analysis, and corneal endothelial cell count before surgery, and 3, 7, 30, and 90 d after surgery were recorded and compared. Pseudophakic accommodation three days, one week, one month, and three months after surgery was determined. Intraoperative ultrasound time and ultrasonic energy were recorded. It was finally concluded that for phacoemulsification with the same phaco tip, a 1.8-mm microincision can lead to quicker recovery of visual acuity, more stable astigmatism, and higher pseudophakic accommodation than conventional incision. | E Song Xin Li Ming-Chao Bi Hua Ren Dan Wang Zhi-Hua Cui Wei Yang Hui Shi Ya-Bin Sun | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 3 | 日地物理学在生物周期研究中的应用(英文)显示文摘在过去的半个世纪中,对于感光生物的近日、近年周期的研究已深入到了基因层面。而在近二十年中,大量的研究主要集中在处于某些太阳周期和地理区域的非感光生物的周期中。生物圈的空间天气在时间和空间上的差别变得越加明显,这一发现指出了日-地-月相互作用生物学中非常重要的物理标记,对于物理学家来说极有意义。通过望远镜的观测记录,这一生物学迹象首次向我们描述了地磁场与精确的七日周期不同的接近七日的周期,以及太阳风和太阳磁场的近年周期。因此,目前需要对以前的和现在新发现的理论、机制进行重新定位,将以前单独的生物和环境节律合并为一个交叉系统,使每一条途径都进一步完善,在适当措施下可同时适用于感光和非感光条件。这些都是值得我们每一个研究者来认真思索的问题。我们也相信不管是关于物理学还是生物圈的研究,随着更多的研究者的努力,都将取得巨大的进步。 | Franz Halberg Germaine Cornélissen George Katinas Sergey Chibisov Dan Holley Jerzy Czaplicki Kuniaki Otsuka Earl E Bakken | 2007 | 西部医学2007，19，2： | 2 |
| 4 | Effect of endothelial progenitor cells derived from human umbilical cord blood on oxygen-induced retinopathy in mice by intravitreal transplantation显示文摘·AIM: To investigate the effect of endothelial progenitor cells(EPCs) labeled by carboxy fluorescein diacetate succinimidyl ester(CFSE) on murine oxygen-induced retinopathy(OIR) by intravitreal transplantation.·METHODS: After isolated from human umbilical cord blood mononuclear cells, EPCs were cultivated and then labeled with CFSE in vitro. C57BL/6J mice were placed to75% hyperoxia chamber from P7 to P12 to establish OIR model. At P12, OIR mice were intravitreally injected with1 μL suspension contained 2×105EPCs(EPCs group) or isometric phosphate buffered saline(PBS group). The contralateral eye of each mice received no injection(OIR group). Evans blue angiography and frozen section were examined to track the labeled cells in OIR group at P15 and P19. Using retina paraffin sections and adenosinediphos phatase staining at P12 and P19, the effect of EPCs on OIR mice was evaluated quantitatively and qualitatively.· RESULTS: The retinas from EPCs group with less non-perfusion area and fewer peripheral tufts wereobserved at P19, comparing with that from PBS or OIR group. The retinopathy in EPCs group receded earlier with less non-ganglion cells and neovascular nuclei,together with relatively regular distribution. The counts of the neovascular nuclei at P19 were reduced by 44% or45%, compared with those of OIR group or PBS group respectively. Three days after EPCs injection, a large number of EPCs appeared in the vitreous cavity and adhered to the retinal surface. While at one week, the cells gathered between the internal plexiform layer and the inner limiting membrane, and some EPCs appeared in retinal vessels.·CONCLUSION: EPCs transplantation can participate in the reparative procedure of the neovascularization in OIR. | Dan Wang Bo Zhang Hui Shi Wei Yang Ming-Chao Bi Xiang-Fu Song Chen Zhang Jian-Hui Cheng Ji-Long Hao E Song | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 2 |
| 5 | Heavy off-road vehicletire-pavement interactions and response 显示文摘 | Siddharthan Raj V Sebaaly Peter E Magdy El-Desouky Strand Dan Huft David | 2005 | Journal ofTransportation Engineering2005，131，3： | 1 |
| 6 | The Future of Nuclear Power: Value Orientations and Risk Perception 显示文摘 | WHITFIELD S C ROSA E A DAN A | 2009 | Risk Analysis2009，29，3： | 1 |
| 7 | Numerical Analysis of Permanent Magnet DC Motor Performances 显示文摘 | Craiu O Dan N Badea E A | 1995 | IEEE Transactions on Magnetics1995，31，6： | 1 |
| 8 | Finite-elementmodeling and calibration of temperature prediction ofhydrating portland cement concrete pavements显示文摘 | Jeong Jin-Hoon Dan G Zollinger P E | 2006 | Journal of Materials in Civil Engineering ASCE2006，18，3： | 1 |
| 9 | Precise Global Collision Detection in Multi-axis NC-machining显示文摘 | Oleg I Gershon E Dan H | | 0，，09： | 1 |
| 10 | An Automated Method for Analysis of Flow Characteristics of Circulating Particles From In vivo Video Microscopy 显示文摘 | Dan E Dan W Michael R | 2008 | IEEE Transactions on Biomedical Engineering2008，55，1： | 1 |
| 11 | Green processing using ionic liquids and CO2 显示文摘 | Blanchard L A Hancu Dan Beckman E J | | Nature0，399，： | 1 |
| 12 | Markers of ap- optosis in cardiovascular tissues: focus on Annexin V 显示文摘 | van Heerde WL Robert-Offerman S Dumont E Hofstra L Doeven- dans PA Smits JF Daemen M J Reutelingsperger CP | 2000 | Cardiovasc Res2000，45，3： | 1 |
| 13 | 查看详情显示文摘 | Zhang J Chu T S Dong S L Yuan S P Fu A E Dan Y B | | 0，，： | 1 |
| 14 | Controlling the false discovery rate in behavior genetics research显示文摘 | Yoav Bi Dan D Greg E Neri K Ilan G | 2001 | Behavioural Brain Research2001，125，1： | 1 |
| 15 | New trie data structures which support very fast search operations 显示文摘 | Dan E W | 1984 | Journal of Computer and System Sciences1984，28，3： | 1 |
| 16 | Hydrogen peroxide pre-treatment induces salt-stress acclimation in maize plant显示文摘 | ANDRE DAN JOSE T P JOAQUIM E | 2005 | Plant physiology2005，，162： | 1 |
| 17 | Physiological reponses of spring durum wheat cultiwurs to early-season drought in a mediterranean environment显示文摘 | Hafid R E L Dan H S Karitou M | 1998 | Ann Bot1998，81，2： | 1 |
| 18 | Probabilistic analysis of resistance degradation of reinforced concrete bridge beams under corrosion显示文摘 | MICHAEL P E DAN M F | 1998 | Engineering Structures1998，，20： | 1 |
| 19 | Cinehonain Ib isolated from Eriobotryajaponica induces insulin secretion in vitro and in vivo 显示文摘 | Qa'dan F Verspohl E J Nahrstedt A | 2009 | J Ethnopharmacol2009，124，2： | 1 |
| 20 | The ring-opening polymerization of D,L-lactide in the melt initiated with tetra- phenyltin 显示文摘 | KOHN F E WAN DEN BERG J W A DAN DE RIDDER G | 1984 | Journal of Applied Polymer Science1984，29，12： | 1 |
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