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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Advances in endoscopic ultrasound imaging of colorectaldiseases显示文摘The development of endoscopic ultrasound(EUS) has had a significant impact for patients with digestive diseases, enabling enhanced diagnostic and therapeutic procedures, with most of the available evidence focusing on upper gastrointestinal(GI) and pancreaticobiliary diseases. For the lower GI tract the main application of EUS has been in staging rectal cancer, as a complementary technique to other cross-sectional imaging methods. EUS can provide highly accurate indepth assessments of tumour infiltration, performing best in the diagnosis of early rectal tumours. In the light of recent developments other EUS applications for colorectal diseases have been also envisaged and are currently under investigation, including beyond-rectum tumour staging by means of the newly developed forward-viewing radial array echoendoscope. Due to its high resolution, EUS might be also regarded as an ideal method for the evaluation of subepithelial lesions. Their differential diagnosis is possible by imaging the originating wall layer and the associated echostructure, and cytological and histological confirmation can be obtained through EUS-guided fine needle aspiration or trucut biopsy. However, reports on the use of EUS in colorectal subepithelial lesions are currently limited. EUS allows detailed examination of perirectal and perianal complications in Crohn's disease and, as a safe and less expensive investigation, can be used to monitor therapeutic response of fistulae, which seems to improve outcomes and reduce the need for additional surgery. Furthermore, EUS image enhancement techniques, such as the use of contrast agents or elastography, have recently been evaluated for colorectal indications as well. Possible applications of contrast enhancement include the assessment of tumour angiogenesis in colorectal cancer, the monitoring of disease activity in inflammatory bowel disease based on quantification of bowel wall vascularization, and differentiating between benign and malignant subepithelial tumours. Recent reports suggest that EUS elastography enables highly accurate discrimination of colorectal adenocarcinomas from adenomas, while inflammatory bowel disease phenotypes can be distinguished based on the strain ratio calculation. Among EUS-guided therapies, the drainage of abdominal and pelvic collections has been regarded as a safe and effective procedure to be used as an alternative for the transcutaneous route, while the placing of fiducial markers under EUS guidance for targeted radiotherapy in rectal cancer or the use of contrast microbubbles as drug-delivery vehicles represent experimental therapeutic applications that could greatly impact the forthcoming management of patients with colorectal diseases, pending on further investigations. | Elena Tatiana Cârțână Dan IonuțGheonea Adrian Săftoiu | 2016 | World Journal of Gastroenterology2016，22，5： | 14 |
| 3 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 5 | Hepatic and extrahepatic malignancies in primary sclerosing cholangitis显示文摘 | Annika Bergquist Anders Ekbom Rolf Olsson Dan Kornfeldt Lars L??f ?ke Danielsson Rolf Hultcrantz Stefan Lindgren Hanne Prytz Hanna Sandberg-Gertzén Sven Almer Fredrik Granath Ulrika Broomé | 2002 | Journal of Hepatology2002，，3： | 2 |
| 6 | Multiphase equilibria calculation by direct minimization of Gibbs free energy with a global optimization method显示文摘 | Dan V N Susana G Eduardo L | 2002 | Computers and Chemical Engineering2002，26，3： | 1 |
| 7 | Numerical Analysis of Permanent Magnet DC Motor Performances 显示文摘 | Craiu O Dan N Badea E A | 1995 | IEEE Transactions on Magnetics1995，31，6： | 1 |
| 8 | JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis 显示文摘 | Prause M Dan PC Billestrup N | 2014 | PLoS One2014，9，87： | 1 |
| 9 | Two constructal routes to minimal heat flow resistance via greater internal complexity 显示文摘 | DAN N | 1999 | Trans ASME: J Heat Transfer1999，121，1： | 1 |
| 10 | Exergy analysis of energy conversion during the thermal interaction between hot particles andwater显示文摘 | BEJAN A DAN N CACUCI D G | 1998 | Energy1998，23，11： | 1 |
| 11 | M3-Deterministic multiscale multirobot Platform for Microsystems packaging显示文摘 | Popa Dan O Murthy Rakesh Das Aditya N | 2009 | IEEE Transactions on Automation Science and Engineering2009，6，2： | 1 |
| 12 | Oxaliplatin -- induced hyperensitivityreaction displayingrnarked elevation of immunoglobulin E显示文摘 | Kitada N Dan T Takara K | 2007 | Joncol Pharm Pratt2007，13，4： | 1 |
| 13 | Dewetting instability during the formation of polymersomes from block-copolymer-stabilized double emulsions显示文摘 | Hayward R C Utada A S Dan N | 2006 | Langmuir2006，22，10： | 1 |
| 14 | Immunobiology of endometriosis 显示文摘 | Dan I Lebovic M D M A Michael D Mueller M D Robert N Taylor M D | 2001 | Fertil Steril2001，75，1： | 1 |
| 15 | Ambient pres- sure effect on single-bubble sonoluminescence显示文摘 | DAN M CHEEKE J D N KONDIC L | 1999 | Physical Review Letters1999，83，9： | 1 |
| 16 | Xaliplatin-induced hyper-sensitivity reaction displaying marked elevation of immunoglobulin E显示文摘 | Kitada N Dan T Takara K | 2007 | J Oncolpharm Pract2007，13，4： | 1 |
| 17 | The amsterdam pleop- erative anxiety and information scale (APAIS) 显示文摘 | Moerman N Van Dan FS Muller MJ | 1996 | AnesthAnalg1996，82，3： | 1 |
| 18 | Ego - enhancement and tourism显示文摘 | DAN N G M S | 1977 | Annals of Tourism Research1977，，17： | 1 |
| 19 | Pathophysiology of duchenne muscular dystrophy: current hypotheses 显示文摘 | Deconinck N Dan B | 2007 | Pediatr Neurol2007，36，1： | 1 |
| 20 | Preparation and characterization of colla- gen - chitosan - chondroitin sulfate com- posite membranes 显示文摘 | Wang K J Dan N H Xiao S W | 2012 | The Journal of Membrane Biology2012，245，11： | 1 |
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