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| 1 | Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss显示文摘Patients with Alzheimer’s disease(AD)often have lower bone mass than healthy individuals.However,the mechanisms underlying this change remain elusive.Previously,we found that Tg2576 mice,an AD animal model that ubiquitously expresses Swedish mutant amyloid precursor protein(APPswe),shows osteoporotic changes,reduced bone formation,and increased bone resorption.To understand how bone deficits develop in Tg2576 mice,we used a multiplex antibody array to screen for serum proteins that are altered in Tg2576 mice and identified hepcidin,a master regulator of iron homeostasis.We further investigated hepcidin’s function in bone homeostasis and found that hepcidin levels were increased not only in the serum but also in the liver,muscle,and osteoblast(OB)lineage cells in Tg2576 mice at both the mRNA and protein levels.We then generated mice selectively expressing hepcidin in hepatocytes or OB lineage cells,which showed trabecular bone loss and increased osteoclast(OC)-mediated bone resorption.Further cell studies suggested that hepcidin increased OC precursor proliferation and differentiation by downregulating ferroportin(FPN)expression and increasing intracellular iron levels.In OB lineage cells,APPswe enhanced hepcidin expression by inducing ER stress and increasing OC formation,in part through hepcidin.Together,these results suggest that increased hepcidin expression in hepatocytes and OB lineage cells in Tg2576 mice contributes to enhanced osteoclastogenesis and trabecular bone loss,identifying the hepcidin-FPN-iron axis as a potential therapeutic target to prevent AD-associated bone loss. | Hao-Han Guo Lei Xiong Jin-Xiu Pan Daehoon Lee Kevin Liu Xiao Ren Bo Wang Xiao Yang Shun Cui Lin Mei Wen-Cheng Xiong | 2021 | Bone Research2021，9，3： | 2 |
| 2 | The prognostic impact of occult nodalmetastasis in early breast carcinoma显示文摘 | Daehoon Park Roll Karesen Bjom Naume | 2009 | Breast Cancer Res Treat2009，118，1： | 1 |
| 3 | The Determinants of Employment Choice of Rural Migrant Workers in China: SOEs and Non-SOEs显示文摘 | Yuling Cui Massimiliano Tani Daehoon Nahm | 2012 | Procedia Economics and Finance2012，，： | 1 |
| 4 | Alternative natural dyes in water purification: Anthocyanin as TiO 2 -sensitizer in methyl orange photo-degradation显示文摘 | Ahed Zyoud Nidal Zaatar Iyad Saadeddin Muath H. Helal Guy Campet Moulki Hakim DaeHoon Park Hikmat S. Hilal | 2011 | Solid State Sciences2011，，6： | 1 |
| 5 | The prognostic impact of occult nodal metastasis in early breast carcinoma显示文摘 | Daehoon Park Rolf K?resen Bj?rn Naume Marit Synnestvedt Elsa Beraki Torill Sauer | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
| 6 | Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation 显示文摘 | Zhou Zheng Xie Jian-xin Daehoon Lee | 2010 | Dev Cell2010，19，1： | 1 |
| 7 | Expression pattern of adhesion molecules (E-cadherin,-,-,-catenin and claudin-7),their influence on survival in primary breast carcinoma,and their corresponding axillary lymph node metastasis显示文摘 | Park Daehoon Karesen | 2007 | APMIS2007，115，1： | 1 |
| 8 | Knowledge-base constructionof a garment manufacturingexpert system 显示文摘 | Chang Kyu Park DaeHoon Lee Tae Jin Kang | 1996 | Inter- national Journal of Clothing Science and Technology1996，，5： | 1 |
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