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| 1 | Carbon Turnover in a Crop Rotation Under Free Air CO_2 Enrichment (FACE)显示文摘. Mostly based on assumptions derived from controlled-environment studies, predicted future atmospheric CO2 concen- trations [CO2] are expected to have considerable impacts on carbon (C) turnover in agro-ecosystems. In order to allow the in situ examination of C-transformations in the plant-soil system of arable crop rotations under future [CO2], a free air carbon dioxide enrichment (FACE) experiment (550 μmol mol-1 CO2) was started at Braunschweig, Germany in 1999. The crop rotation under investigation comprised winter barley, a cover crop (ryegrass), sugar beets and winter wheat. Assessments of CO2 effects included the determination of above- and belowground biomass production, measurements of canopy CO2- and H2O- fluxes, soil microbial biomass and in situ soil respiration. The results obtained during the 1st crop rotation cycle (3 years) showed that for the selected crops elevated [CO2] entailed significant positive effects (P < 0.05) on aboveground (6%-14% stimulation) and belowground biomass production (up to 90% stimulation), while canopy evapotranspiration was reduced. This resulted in increased soil water content. Also, depending on crop type and season, high CO2 stimulated in situ soil respiration (up to 30%), while soil microbial biomass did not show significant responses to elevated [CO2] during the first rotation cycle. | H. J. WEIGEL A. PACHOLSKI S. BURKART M. HELAL O. HEINEMEYER B. KLEIKAMP R. MANDERSCHEID C. FRüHAUF G. F. HENDREY K. LEWIN J. NAGY | 2005 | Pedosphere2005，15，6： | 12 |
| 2 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 3 | Multivariate metal-organic frameworks显示文摘Reticular chemistry is founded upon the principles of linking simple organic and inorganic building blocks through strong bonds to form extended,porous and crystalline solids,such as metal-organic frameworks(MOFs)[1].This field | Aasif Helal Zain H.Yamani Kyle E.Cordova Omar M.Yaghi | 2017 | National Science Review2017，4，3： | 10 |
| 4 | Size and spatial distribution of landslides induced by the2015 Gorkha earthquake in the Bhote Koshi river watershed显示文摘The Mw 7.8 Gorkha earthquake in Nepal on April 25, 2015, produced thousands of landslides in the Himalayan mountain range. After the earthquake, two field investigations along Araniko Highway were conducted. Then, using remote sensing technology and geographic information system(GIS)technology, 1481 landslides were identified along the Bhote Koshi river. Correlations between the spatial distribution of landslides with slope gradient and lithology were analyzed. The power-law relationship of the size distribution of earthquake-induced landslides was examined in both the Higher Himalaya and Lesser Himalaya. Possible reasons for the variability of the power exponent were explored by examining differences in the geological situations of these areas. Multi-threshold cellular automata were introduced to model the complexity of system components. Most of the landslides occurred at slope gradients of 30°–40°, and the landslide density was positively correlated with slope gradient. Landslides in hard rock areas were more common than in soft rock areas. The cumulative number-area distribution of landslides induced by the Gorkha earthquake exhibited a negative power-law relationship, but the power exponents were different: 1.13 in the Higher Himalaya, 1.36 and Lesser Himalaya. Furthermore,the geological conditions were more complex and varied in the Lesser Himalaya than in the Higher Himalaya, and the cellular automata simulation results indicated that, as the complexity of system components increased, the power exponent increased.Therefore, the variability of the power exponent of landslide size distribution should ascribe to the complexity of geological situations in the Bhote Koshi river watershed. | GUO Chen-wen HUANG Yi-dan YAO Ling-kan ALRADI Helal | 2017 | Journal of Mountain Science2017，14，10： | 6 |
| 5 | HBsAg, HBcAg, and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection显示文摘BACKGROUND: As the host immunity is diminished in patients with chronic hepatitis B (CHB), different approaches have been used to up-regulate their immune responses to produce therapeutic effects. But, cytokines, growth factors and polyclonal immune modulators could not exhibit sufficient therapeutic effects in these patients. Immune therapy with HBV-related antigens (vaccine therapy) has been used in CHB patients. But there is a paucity of information about the design of HBV antigen-based immune therapy in these patients. DATA SOURCE: Preclinical and clinical studies on immune therapy with HBsAg-based vaccine, HBcAg and combination of HBsAg/HBcAg-based vaccines have been discussed. RESULTS: HBsAg-based prophylactic vaccine was used as an immune therapeutic agent in CHB patients; however, monotherapy with HBsAg-based immune therapy could not lead to sustained control of HBV replication and/or liver damages. HBsAg-based vaccine was used as a combination therapy with cytokines, growth factors, and antiviral drugs. HBsAg-based vaccine was also used for cell-based therapy. However, satisfactory therapeutic effects of HBsAg-based vaccine could not be documented in CHB patients. In the mean time, evidences have supported that HBcAg-specific immunity is endowed with antiviral and liver protecting capacities in CHB patients. Recent data concentrate on the clinical use of combined HBsAg- and HBcAg-based vaccines in CHB patients.CONCLUSION: Antigen-based immune therapy with HBV- related antigens may be an alternative method for the treatment of CHB patients but proper designs of antigens, types of adjuvants, dose of vaccinations, and routes of administration need further analyses for the development of an effective regimen of immune therapy against HBV. | Sheikh Mohammad Fazle Akbar Mamun Al-Mahtab Mohammad Helal Uddin Md. Sakirul Islam Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 5 |
| 6 | Oxidative leaching kinetics of molybdenum-uranium ore in H2SO4 using H2O2 as an oxidizing agent显示文摘用氧化剂被调查了的氢过氧化物在一个硫磺的酸答案处理铝铀矿石。沥滤的温度,氢过氧化物集中,硫磺的酸集中,沥滤的时间,粒子尺寸, liquid-to-solid 比率和焦虑速度都在这个过程上有重要效果。 | T. A. Lasheen M. E. EI-Ahmady H. B. Hassib A. S. Helal | 2013 | Frontiers of Chemical Science and Engineering2013，7，1： | 5 |
| 7 | 基于激光跟踪仪的机身桶段测量技术研究显示文摘目前传统测量技术已难以满足飞机制造中不断提高的检测要求,数字化测量技术已成为提高飞机产品检测效率与质量的重要手段。针对这一发展趋势,通过基于激光跟踪仪的机身桶段测量技术研究,系统地总结了飞机产品测量中激光跟踪仪测量场的组成、建立飞机测量坐标系的方法以及激光跟踪仪转站的原理。结合某型飞机前机身桶段的测量过程,重点介绍了利用激光跟踪仪对机身桶段关键特性和关键对接点进行在线测量及数据分析的方法,分析验证了激光跟踪仪系统在飞机产品测量中的应用情况。 | 王巍 李昂 MD HELAL MIAH | 2017 | 装备制造技术2017，，12： | 4 |
| 8 | Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects显示文摘BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide.These defects generally result from severe trauma or resection of a whole large tumour.Autologous bone grafts are the current gold standard for the reconstruction of such defects.However,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be introduced.To find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone regeneration.AIM To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat model.METHODS Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur.Rats were allocated to three equal groups of 21 rats each.Group I bone defects were irrigated with normal saline and designed as negative controls.Defects of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs.Seven rats from each group were killed at 1,2 and 4 wk.The mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical staining.RESULTS Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone. | Muhammad A Awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish | 2020 | World Journal of Stem Cells2020，12，1： | 4 |
| 9 | Hydrodynamic Characteristics of Three Rows of Vertical Slotted Wall Breakwaters显示文摘In this study, we examine the hydrodynamic characteristics of three rows of vertical slotted wall breakwaters in which the front and middle walls are permeable and partially immersed in a water channel of constant depth, whereas the third wall is impermeable. The wave–structure interaction and flow behavior of this type of breakwater arrangement are complicated and must be analyzed before breakwaters can be appropriately designed. To study the hydrodynamic breakwater performance, we developed a mathematical model based on the eigenfunction expansion method and a least squares technique for predicting wave interaction with three rows of vertical slotted wall breakwaters. We theoretically examined the wave transmission, reflection, energy loss, wave runup, and wave force under normal regular waves. Comparisons with experimental measurements show that the mathematical model results adequately reproduce most of the important features. The results of this investigation provide a better understanding of the hydrodynamic performance of triple-row vertical slotted wall breakwaters. | Majed O. Alsaydalani Mohammed A. N. Saif Medhat M. Helal | 2017 | Journal of Marine Science and Application2017，16，3： | 4 |
| 10 | 基于投影寻踪分类法的甘蔗种质综合评价显示文摘基于投影寻踪分类法对40份从法国和菲律宾引进的甘蔗种质进行综合评价。方差分析结果表明,各种质间茎径、单茎质量、蔗糖分等主要工农艺性状均存在显著差异(P<0.01),变异系数介于5.68%~51.55%,变异广泛。对各种质的株高、茎径、有效茎、单茎质量、锤度、甘蔗蔗糖分、蔗汁蔗糖分、简纯度和纤维分等9个主要工农艺性状指标进行投影方向和投影值大小分析,结果表明:投影方向以甘蔗蔗糖分的最高,其后依次为锤度、蔗汁蔗糖分、简纯度、单茎质量和茎径等,株高和有效茎的较低;40份种质投影值大小各异,根据投影值大小,结合聚类分析将40份种质划分为5个类群,各类群投影值介于0.00~2.50,其中,第Ⅳ类群的5份种质资源(FR97–127、FR97–53、VMC95–29、VMC96–169和VMC97–30)综合性状表现优良,可供甘蔗杂交利用。综合来看,投影寻踪分类法可作为大量甘蔗种质资源评价的有效途径。 | 武晋宇 应雄美 朱建荣 赵俊 刘家勇 吴才文 Ibrahim Soliman Helal ELGAMAL 赵勇 | 2020 | 湖南农业大学学报(自然科学版)2020，46，2： | 2 |
| 11 | PI3K/AKT信号转导通路与人舌鳞癌细胞TCA8113顺铂耐药的相关性研究显示文摘目的:探讨PI3K特异性抑制剂LY294002逆转顺铂耐药口腔鳞癌细胞TCA8113/CDDP的可行性。方法:采用间歇性加药,逐步递增CDDP药量,体外连续诱导培养TCA8113/CDDP细胞;用不同浓度的LY294002和顺铂处理TCA8113和TCA8113/CDDP细胞;MTT法观察对细胞增殖的影响,Western印迹分析LY294002作用前后p-Akt、Akt、PI3K蛋白的表达。结果:建立了舌鳞癌耐药细胞TCA8113/CDDP,耐药指数为7.7;MTT实验显示LY294002对TCA8113和TCA8113/CDDP细胞的抑制作用与浓度及作用时间呈正相关;LY294002联合顺铂对2种细胞的抑制作用比单用顺铂效果好;PI3K、Akt、p-AKT蛋白表达明显降低,其中TCA8113/CDDP细胞中PI3K、AKT、p-AKT蛋白的表达比TCA8113细胞明显增多(P<0.05)。结论:LY294002能增加耐药口腔鳞癌顺铂化疗的敏感性。 | 齐长娥 李德超 朱杨 姚丛姗 Hussein Helal 赵艳宇 | 2014 | 生物技术通讯2014，25，3： | 2 |
| 12 | A new approach for fuel injection into a solar receiver/ reactor:Numerical and experimental investigation显示文摘An innovative and efficient design of solar receivers/reactors can enhance the production of clean fuels via concentrated solar energy.This study presents a new jet-type burner nozzle for gaseous feedstock injection into a cavity solar receiver inspired from the combustion technology.The nozzle design was adapted from a combustion burner and successfully implemented into a solar receiver and studied the influence of the nozzle design on the fluid mixing and temperature distribution inside the solar receiver using a 7 kW solar simulator and nitrogen as working fluid.Finally,a thorough computational fluid dynamics (CFD) analysis was performed and validated against the experimental results.The CFD results showed a variation of the gas flow pattern and gas mixing after the burner nozzle adaptation,which resulted an intense effect on the heat transfer inside the solar receiver. | M Helal Uddin Nesrin Ozalp Jens Heylen Cedric Ophoff | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 2 |
| 13 | Lymphocytic colitis: A clue to bacterial etiology显示文摘AIM: To find out the role of bacteria as a possible etiological factor in lymphocytic colitis.METHODS: Twenty patients with histopathological diagnosis of lymphocytic colitis and 10 normal controls were included in this study. Colonoscopic biopsies were obtained from three sites (hepatic and splenic flexures and rectosigmoid region). Each biopsy was divided into two parts. A fresh part was incubated on special cultures for bacterial growth. The other part was used for the preparation of histologic tissue sections that were examined for the presence of bacteria with the help of Giemsa stain.RESULTS: Culture of tissue biopsies revealed bacterial growth in 18 out of 20 patients with lymphocytic colitis mostly Escherichia coli(14/18), which was found in all rectosigmoid specimens (14/14), but only in 8/14 and 6/14 of splenic and hepatic flexure specimens respectively. In two of these cases, E coliwas associated with proteus. Proteus was found only in one case, Klebsiella in two cases, and Staphylococcus aureus in one case. In the control group, only 2 out of 10 controls showed the growth of E coliin their biopsy cultures.Histopathology showed rod-shaped bacilli in the tissue sections of 12 out of 14 cases with positive E coliin their specimen's culture. None of the controls showed these bacteria in histopathological sections.CONCLUSION: This preliminary study reports an association between E coliand lymphocytic colitis, based on histological and culture observations. Serotyping and molecular studies are in process to assess the role of E coliin the pathogenesis of lymphocytic colitis. | Thanaa EA Helal Naglaa S Ahmed Osama Abo El Fotoh | 2005 | World Journal of Gastroenterology2005，11，46： | 2 |
| 14 | Clinical impact of (18) F-FDG PET in thyroid carcinoma patients with elevated thyroglobulin levels and negative (131)I scanning results after therapy显示文摘 | Helal BO Merlet P Toubert ME | 2001 | J Nucl Med2001，42，： | 1 |
| 15 | The Hickman peel-away sheath:alternative for pediatric percutaneous nephrolithotomy显示文摘 | Helal M Blank T Lockhart J | 1997 | J Endourol1997，11，3： | 1 |
| 16 | Reduction of carbonyl compounds with chiral oxazaborolidine catalysts: a new paradigm for enantioselective catalysis and a powerful new synthetic method 显示文摘 | COREY E J HELAL C J | 1998 | Angew Chem Int Ed1998，37，15： | 1 |
| 17 | Association betweenNterminal propeptide B-type natriuretic peptide and markers ofhypervolemia显示文摘 | Gangji A S Helal B A Churchill D N | 2008 | Perit Dial Int2008，28，3： | 1 |
| 18 | Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome : relationship with oxidative stress 显示文摘 | Helal O Dcfoort C Robert S | 2011 | Nutr Metab Cardiovasc Dis2011，21，： | 1 |
| 19 | Varietal differences in root phosphatase activity as related to the utilization of organic phosphates显示文摘 | H. M. Helal | 1990 | Plant and Soil1990，，2： | 1 |
| 20 | Metallothionein Induction Reduces Caspase-3 Activity and Tnfα Levels with Preservation of Cognitive Function and Intact Hippocampal Neurons in Carmustine-Treated Rats显示文摘 | Gouda K. Helal Abdulaziz M. Aleisa Omayma K. Helal Salim S. Al-Rejaie Abdulaziz A. Al-Yahya Abdulhakeem A. Al-Majed Othman A. Al-Shabanah | 2009 | Oxidative Medicine and Cellular Longevity2009，，1： | 1 |
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