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| 1 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 2 | Temperature monitoring utilising thermoacoustic signals during pulsed microwave thermotherapy:A feasibility study 显示文摘 | LOU Cunguang XING Da | 2010 | International Journal of Hyperthermia2010，26，4： | 1 |
| 3 | Thermal for- mation of mesoporous single-crystal Co3 04 nano-needles and their lithium storage properties 显示文摘 | Lou Xiongwen Deng Da Lee Jimyang | 2008 | J Mater Chem2008，18，： | 1 |
| 4 | Self-suppor- ted formation of needlelike Co3 04 nanotubes and their ap- plication as lithium-ion battery electrodes 显示文摘 | Lou Xiongwen Deng Da Lee Jimyang | 2008 | Adv Ma- ter2008，20，： | 1 |
| 5 | Characteristics of the Cretaceous Magmatism in Huanghua Depression and Their Relationships with Hydrocarbon Enrichment显示文摘The Huanghua depression located in the hinterland of the Bohai Bay Basin in eastern China is a typical area for the research of multistage magmatic activities with hydrocarbon enrichment,many high-yield wells related to igneous rocks were discovered within the Cretaceous strata in recent years.However,the spatial and temporal distribution of Cretaceous igneous rocks remains unclear,and the relationships among magmatic sequence,lithology,and hydrocarbon enrichment have been poorly studied.In order to solve these problems,core observation,logging analysis,major element analysis,zircon U-Pb chronology,oil-bearing grade statistics and reservoir spaces analysis were used to subdivide the magmatism cycles and to investigate the characteristics of igneous reservoirs.Our results show that the Mesozoic magmatism in Huanghua depression started in 140.1±1.4 Ma and could be divided into two stages including the Early Cretaceous stage and Late Cretaceous stage.The Early Cretaceous magmatism principally developed basic-intermediate rocks in the north zone,and could be subdivided into 3 cycles with their forming ages of 140,125–119,and 118–111 Ma,respectively.By contrast,the late stage mainly developed intermediate-acid rocks centralized in the south zone and formed at 75–70 Ma.The GR and SP curves are good indicators for the contrast of different lithologies,lithofacies and for magmatic sequences division.Intensive magmatism may have an advantage to form reservoirs,since basalt in cycle III in the Early Cretaceous and dacite porphyrite in the Late Cretaceous have great exploration potential.Lithology and tectonic fractures have an important influence on the formation of reservoir spaces and hydrocarbon enrichment.The characteristics of Cretaceous magmatism and igneous reservoirs in Huanghua depression and adjacent areas are summarized,providing important information for igneous reservoirs research and oil-gas exploration in the Cretaceous in related areas. | Fengming Jin Jian Huang Xiugang Pu Changqian Ma Lixin Fu Chongbiao Leng Da Lou Mutian Qin | 2020 | Journal of Earth Science2020，31，6： | 1 |
| 6 | Hydrothermal synthesis of nitrogen-containing carbon nanodots as the high-efficient sensor for copper(II) ions显示文摘 | Yunfei Sha Jiaying Lou Shizhe Bai Da Wu Baizhan Liu Yun Ling | 2012 | Materials Research Bulletin2012，，： | 1 |
| 7 | Discriminating hydrocarbon generation potential of coaly source rocks and their contribution:a case study from the Upper Paleozoic of Bohai Bay Basin,China显示文摘Although various coaly source rocks widely developed in the Carboniferous-Permian(C-P)of the Bohai Bay Basin,their geochemical characteristics and hydrocarbon generation potential are poorly understood.This study aims to discriminate the contribution of hydrocarbon generation from different C-P coaly source rocks and clarify the differences within generated oils using organic geochemistry,organic petrology,and thermal simulation experiments.The coaly source rocks containt coal clarain and durain,carbonaceous shale,and shale deposited in deltaic and lagoonal environment.The results indicated that clarain,durain,and carbonaceous shale exhibited higher hydrogen index and liquid-gas hydrocarbon yields than lagoonal and deltaic shales,which was mainly associated with the concentrations of sporinite,cutinite,and hydrogen-rich collodetrinite.Aliphatic hydro-carbons originated firom coal and carbonaceous shale presented lower Ts/(Ts+Tm),Ga/17α(H)21β(H)-C_(30)hopane,18α(H)-oleanane/17α(H)21β(H)-C_(30)hopane ratios,and higher 17β3(H)21α(H)-C_(30)Morane/17α(H)21β(H)-C_(30)hopane than deltaic lagoonal shales.Parameters of aromatic hydrocarbons generated from five lithologies of coaly source rocks trended as clear group distribution,e.g.,clarain and durain showing lower MNR,DBT/Fluorene(F)ratios and higher DBF/F ratio than coaly shales.The distinct descending trend of hydrocarbon potential is obtained from clarain,durain,carbonaceous shale to lagoonal and deltaic shales,implying dominated the petroleum and natural gas supplement from coal and carbonaceous shale.The difference between aliphatic and aromatic hydrocarbons provides a significant contribution to analyze the generic relationship between coaly source rock and lacustrine shale.Our results illustrate the importance of coaly source rocks for the in-depth oil-gas exploration of the Bohai Bay Basin and understanding hydrocarbon generation potential of source rocks in coal bearing strata. | Jinjun XU Da LOU Qiang JIN Lixin FU Fuqi CHENG Shuhui ZHOU Xiuhong WANG Chao LIANG Fulai LI | 2021 | Frontiers of Earth Science2021，15，4： | 1 |
| 8 | Preparation of SnO2/carbon composite hollow spheres and their lithium storage properties显示文摘 | Lou Xiongwen Deng Da JimYang Lee | 2008 | Chem Mater2008，20，20： | 1 |
| 9 | Characteristics of Helicobacter pylori natural transformation显示文摘 | Israel DA Lou AS Blair MJ | 2000 | FEMS Microbiol Lett2000，186，2： | 1 |
| 10 | Evolution characteristics and exploration targets of Permian clastic rock reservoirs in Bohai Bay Basin,East China显示文摘Based on core observation, thin section examination, fluid inclusions analysis, carbon and oxygen isotopic composition analysis, and other approaches, the structural and burial evolution histories were investigated, and the diagenetic evolution process and genetic/development models were systematically discussed of the Upper Paleozoic Permian clastic rock reservoirs in the Bohai Bay Basin, East China. The Bohai Bay Basin underwent three stages of burial and two stages of uplifting in the Upper Paleozoic. Consequently, three stages of acid dissolution generated by the thermal evolution of kerogen, and two stages of meteoric freshwater leaching occurred. Dissolution in deeply buried, nearly closed diagenetic system was associated with the precipitation of authigenic clay and quartz, leading to a limited increase in storage space. Different structural uplifting–subsidence processes of tectonic zones resulted in varying diagenetic–reservoir-forming processes of the Permian clastic reservoirs. Three genetic models of reservoirs are recognized. The Model I reservoirs with pores formed in shallow strata and buried in shallow to medium strata underwent two stages of exposure to long-term open environment and two stages of meteoric freshwater leaching to enhance pores near the surface, and were shallowly buried in the late stage, exhibiting the dominance of secondary pores and the best physical properties. The Model Ⅱ reservoirs with pores formed in shallow strata and preserved due to modification after deep burial experienced an early exposure-open to late burial-closed environment, where pore types were modified due to dissolution, exhibiting the dominance of numerous secondary solution pores in feldspar and the physical properties inferior to Model I. The Model Ⅲ reservoirs with pores formed after being regulated after multiple periods of burial and dissolution experienced a dissolution of acidic fluids of organic origin under a near-closed to closed environment, exhibiting the dominance of intercrystalline micropores in kaolinite and the poorest physical properties. The target reservoirs lied in the waterflood area in the geological period of meteoric freshwater leaching, and are now the Model Ⅱ deep reservoirs in the slope zone–depression zone. They are determined as favorable options for subsequent exploration. | CAO Yingchang SUN Peipei ZHOU Lihong YUAN Guanghui LIU Huimin LOU Da WU Zhiping JIN Qiang JIANG Youlu | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 11 | Formation of the primary petroleum reservoir in Wumaying inner buried-hill of Huanghua Depression, Bohai Bay Basin, China显示文摘Well Yinggu 1 drilled on the tectonic belt of the Wumaying buried-hill in Huanghua Depression obtained non-H2S high-yield oil and gas flow from the Permian Lower Shihezi Formation sandstone. The oil and gas are derived from the Upper Paleozoic coal source rock, the petroleum reservoir is an inner buried-hill primary oil and gas accumulation, showing a good prospect of the Paleozoic inner buried-hill primary reservoir exploration. The formation and accumulation of the primary petroleum reservoir in the Wumaying inner buried-hill are discussed by studying the primary source conditions, the inner buried-hill reservoir-cap combinations and the hydrocarbon accumulation period. The primary petroleum reservoir has three preponderant characteristics of accumulation: secondary large-scale gas generation of coal source rock, multi reservoir-cap combinations and mainly late hydrocarbon charging, which formed the compound hydrocarbon accumulation of the above-source sandstone and under-source carbonate rock in the Paleozoic inner buried-hill. Along with the Mesozoic and Cenozoic tectonic activities, the formation of the primary reservoir in Wumaying inner buried-hill is characterized by 'mixed oil and gas charge in local parts in early stage, adjustment accumulation due to structural high migration in middle stage, and large-scale natural gas charge and compound accumulation in late stage'. | JIN Fengming WANG Xin LI Hongjun WU Xuesong FU Lixin LOU Da ZHANG Jinning FENG Jianyuan | 2019 | Petroleum Exploration and Development2019，46，3： | 0 |
| 12 | Decipher hydrocarbon generation and accumulation based on fluid inclusion and chronology:A case study from the Upper Paleozoic buried-hills in Huanghua Depression,Bohai Bay Basin显示文摘Deciphering hydrocarbon generation and accumulation stage is of significance to understand oil and gas evolution and seek exploration targets.Taking the Upper Paleozoic buried-hills in the Huanghua Depression,Bohai Bay Basin,as a case study,hydrocarbon generation environment and detailed accumulation process are revealed by fluid inclusions observations,Laser Raman spectroscopy,Fourier Infrared spectroscopy,and K-Ar isotope measurements.The results show that both oil and gas inclusion were captured in the quartz overgrowth,dissolved feldspar and calcite microfractures,showing blue to dark brown fluoresce.The grains containing oil inclusions index(GOI)of oil,oil&gas and gas being 25%,65%,and 10%and the inclusions with abundant methyl groups and short chains,both indicate high thermal maturity.One series of fluids inclusion is generally observed,evidenced by the concentrated homogenization temperature of 135-145℃ and salinity of 3%-15 w.t.%NaCl equiv,indicating one primary charging stage.The gas and gas&liquid inclusions mainly contain CH_(4),with also peaks indicating CO_(2) and N_(2.)The Carboniferous and Permian biomarkers show reducing environment with brackish water,with organic matter sources both from marine and continental.The relative content ofααα20RC_(27),ααα20RC_(28),andααα20RC_(29) exhibit source contributions both from algae and higher plants,and mainly of II2 to III kerogen.Both coal derived gas and oil associated hydrocarbons are identified from most of the buried-hills.Combining the fluid homogenization temperature and salinity,as well as the thermal evolution history,the hydrocarbon generated from the Upper Paleozoic was concentrated at the end of the Eocene(40 Ma±),while the beginning of charging is 60 Ma±.The Wumaying Buried-hill is of only coal derived gas and has potential for inner coal measure natural gas exploration.The results provide a detailed understanding of hydrocarbon accumulations in the study area,which can also be reference for improving petroleum exploration efficiency in similar basins. | Li-Hong Zhou Yong Li Feng-Ming Jin Jin-Feng Xie Xiu-Gang Pu Li-Xin Fu Da Lou Yang Tian | 2023 | Petroleum Science2023，20，4： | 0 |
| 13 | Magmatic hydrothermal fluid genesis of zeolite in the Paleogene Kongdian Formation of Zaoyuan oilfield,Bohai Bay Basin,China显示文摘Electronic probe,fluid inclusion homogenization temperature,Raman spectroscopy and laser ablation inductively coupled plasma mass spectrometry were utilized to identify the hydrothermal fluid-rock interactions in the second member of the Paleogene Kongdian Formation of Zaoyuan oilfield in Bohai Bay Basin(Kong 2 Member for short)of Well Z56 to find out the relationship between zeolite and hydrothermal fluid.The experimental results show that:(1)Pyrobitumen coexists with hydrothermal fluid characteristic minerals such as chlorite,barite,chalcopyrite,pyrite,natrolite and analcime in mudstone fractures.(2)The temperatures calculated from laser Raman spectrum of pyrobitumen,from the chlorite geothermometer and from measured homogenization temperature of natrolite inclusions are 324-354℃,124-166℃ and 89-196℃,respectively;although vary widely,all the temperatures are obviously higher than the normal geothermal temperature.(3)The positive Eu anomaly of chlorite and barite,and the similar distribution pattern in rare earth elements between natrolite and basalt indicate they are from magmatic hydrothermal fluid.Moreover,drilling data shows that the Kong 2 Member in Well Z56 has several sets of basalt interlayers,suggesting there was geologic base of magmatic hydrothermal fluid activity.The magmatic hydrothermal fluid-rock interaction may be one of the reasons for the abnormal enrichment of zeolite in Kong 2 Member of the Cangdong Sag. | HAN Guomeng WANG Li XIAO Dunqing LOU Da XU Muyue ZHAO Yonggang PEI Yanlu GUO Xiaowen TENG Jiancheng' HAN Yuanjia | 2021 | Petroleum Exploration and Development2021，48，5： | 0 |
| 14 | Effect of Sterilization Methods on Cell Binding Activity of Surface-immobilized Fibronectin显示文摘在 biomaterials 的表面上的 fibronectin 的生物活动的消毒方法的效果在现在的学习被详细描述。无菌的修改蛋白质的 biomaterials 被 microfilter 过滤和紫外照耀分别地制作。紫外照耀改变了吸附表面的 fibronectin 的符合构造并且进一步影响了附件,形态学和 endothelial 房间的生物功能。然而, microfilter 过滤改变 fibronectin,或增长和 endothelial 房间的生物功能的正常符合构造,显示那 microfilter 过滤消毒是为蛋白质底层的最合适的方法。 | XING Hai Bo PAN Qin WANG Kai Feng LOU Fang LI Da | 2014 | Biomedical and Environmental Sciences2014，27，5： | 0 |
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