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| 1 | Helicobacter pylori recurrence after eradication in Latin America:Implications for gastric cancer prevention显示文摘AIM To estimate Helicobacter pylori(H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden.METHODS Pub Med, LILACS, Sci ELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants' characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model. The I2 statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTS Literature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years(95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence,was 11.2(6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2(3.8-8.7).CONCLUSION H. pylori recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs. | Juan E Corral Robertino Mera Corey W Dye Douglas R Morgan | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 5 |
| 2 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 3 | Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury显示文摘 | Min HE Ni CHENG Wei-wei GAO Meng ZHANG Yue-yun ZHANG Richard DYE Ming-wei WANG | 2011 | Acta Pharmacologica Sinica2011，32，5： | 3 |
| 4 | Endoscopic and Radiographic Evaluation of the Small Bowel in 2012显示文摘 | Charles E. Dye Ryan R. Gaffney Thomas M. Dykes Matthew T. Moyer | 2012 | The American Journal of Medicine2012，，12： | 2 |
| 5 | Double Balloon Enteroscopy Detects Small Bowel Mass Lesions Missed by Capsule Endoscopy显示文摘 | Andrew Ross Shahab Mehdizadeh Jeffrey Tokar Jonathan A. Leighton Ahmad Kamal Ann Chen Drew Schembre Gary Chen Kenneth Binmoeller Richard Kozarek Irving Waxman Charles Dye Lauren Gerson M. Edwyn Harrison Oleh Haluszka Simon Lo Carol Semrad | 2008 | Digestive Diseases and Sciences2008，，8： | 2 |
| 6 | Thermomechanical processing of Ti–5Al–5Mo–5V–3Cr显示文摘 | N.G. Jones R.J. Dashwood D. Dye M. Jackson | 2008 | Materials Science & Engineering A2008，，1： | 2 |
| 7 | Topical Negative Pressure Stimulates Endothelial Migration and Proliferation: A Suggested Mechanism for Improved Integration of Integra显示文摘 | Christopher Baldwin Matthew Potter Elizabeth Clayton Laurie Irvine Julian Dye | 2009 | Annals of Plastic Surgery2009，，1： | 2 |
| 8 | TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance显示文摘Osimertinib(AZD9291)has been widely used for the treatment of EGFR mutant non-small cell lung cancer.However,resistance to osimertinib is inevitable.In this study we elucidated the molecular mechanisms of resistance in osimertinib-resistant NCI-H1975/OSIR cells.We showed that NCI-H1975/OSIR cells underwent epithelial–mesenchymal transition(EMT),which conferred sensitivity to the GPX4 inhibitor 1S,3R-RSL3 to induce ferroptotic cell death.The EMT occurrence resulted from osimertinib-induced upregulation of TGFβ2 that activated SMAD2.On the other hand,we revealed that NCI-H1975/OSIR cells were highly dependent on NF-κB pathway for survival,since treatment with the NF-κB pathway inhibitor BAY 11-7082 or genetic silence of p65 caused much greater cell death as compared with the parental NCI-H1975 cells.In NCI-H1975 cells,osimertinib activated NF-κB pathway,evidenced by the increased p65 nuclear translocation,which was abolished by knockdown of TGFβ2.In the cancer genome atlas lung adenocarcinoma data,TGFB2 transcript abundance significantly correlated with EMT-associated genes and NF-κB pathway.In addition,coexistence of EMT and activation of NF-κB pathway was observed in several NCI-H1975/OSIR clones.These findings shed new light on distinct roles of TGFβ2 in osimertinib-resistant cells and provide new strategies for treatment of this resistant status. | Xiao-ming Jiang Yu-lian Xu Luo-wei Yuan Le-le Zhang Mu-yang Huang Zi-han Ye Min-xia Su Xiu-ping Chen Hong Zhu Richard DYe Jin-jian Lu | 2021 | Acta Pharmacologica Sinica2021，42，3： | 2 |
| 9 | Complications Associated With Double Balloon Enteroscopy at Nine US Centers显示文摘 | Lauren B. Gerson Jeffrey Tokar Michael Chiorean Simon Lo G. Anton Decker David Cave Doumit BouHaidar Daniel Mishkin Charles Dye Oleh Haluszka Jonathan A. Leighton Alvin Zfass Carol Semrad | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 10 | 化疗使得结核病疫情下降:摩洛哥案例分析显示文摘背景:摩洛哥从20世纪90年代初期就开始实施世界卫生组织(WHO)推荐的DOTS策略,但在1996—2005年间结核病人报告率的年递降率仅为3%~4%。以目前的疫情下降趋势,到2050年(即实现全球消灭结核病的目标年),摩洛哥仍将新发生1万例以上的结核病人。方法:对1996—2005年间国家结核病控制规划报告的病人,按年龄、性别、临床分型和地区进行分析。以4个标准判断观察结果的准确性:统计学有效性、测量精度、生物学合理性,以及不同证据链显示的一致性和关联强度。结果:城市地区的结核病发病(病人数和发病率)高于农村,成年男性的发病率高于女性。男性结核病人中,痰涂片阳性(最具传染性)的比例高于女性。2005年,在所有痰涂片阳性病人中, 15~44岁的男性占了近一半。男性的发病率下降速度低于平均水平,但女性发病率的下降速度也较预期的慢。结论:在摩洛哥,城市男性人群是结核病防治的重点对象。就总体而言,应对常规监测数据进行深入研究,以发挥其对结核病控制活动的指导作用。 | C. Dye S. Ottmani L. Laasri N. Bencheikh 刘青(译) 贺晓新(校) 王雪静(审) | 2008 | 国际结核病与肺部疾病杂志2008，3，3： | 2 |
| 11 | Evaluating North American Net Primary Productivity with Satellite Observations显示文摘 | Dye D G | 1987 | Advances in Space Research1987，7，11： | 1 |
| 12 | Taxonomic clarification of Xanthomonas vesicatoria based upon host specificity, bacterio-phage sensitivity and cultural characteristics显示文摘 | Dye D W Starr M P Stolp H | 1964 | Phytopathol- ogische Zeitschrift1964，51，： | 1 |
| 13 | Gender and tuberculosis: a comparison of prevalence surveys with notification data to explore sex differences in case detection显示文摘 | Borgdorff MW Nagelkerke N J Dye C | 2000 | Int J Tuberc Lung Dis2000，4，： | 1 |
| 14 | Target modification in the excimer laser deposition of YBa2Cu3O7- x thin films显示文摘 | Foltyn S R Dye R C Ott K C | 1991 | Appl Phys Lett1991，59，： | 1 |
| 15 | An EOQ Model for Deteriorating Items with Time Varying Demand and Partial Backlogging显示文摘 | Chang H J Dye C Y | 1999 | J of the Operational Research Society1999，50，11： | 1 |
| 16 | Influence of bovine growth hormone on growth rate,appetite,and food conversion of yearling coho salmon (Oncorhyrtchus kisutch) fed two diets of different composition显示文摘 | MARKERT J R HIGGS D A DYE H M | 1977 | Can J Zool1977，55，1： | 1 |
| 17 | 显示文摘 | MAKERT J R HIGGS D A DYE H M | 1977 | Can J Zool1977，55，： | 1 |
| 18 | The effects of stress on plasma ACTH, alpha-MSH, and eortisol levels in salmonid fishes显示文摘 | Sumpter J P Dye H M Benfey T J | 1986 | Gen Comp Endocrinol1986，62，3： | 1 |
| 19 | Global epidemiology of tuberculosis 显示文摘 | Dye C | 2006 | Lancet2006，367，： | 1 |
| 20 | Global Burden of tu berculosis = Estimated incidence, prevalence, and mor- tality by country显示文摘 | Dye C Scheele S Dolin P | 1999 | Jama1999，282，7： | 1 |
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