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| 1 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 2 | Summary of Report on Cardiovascular Diseases in China,2012显示文摘The prevalence of cardiovascular diseases(CVDs)is associated with the socioeconomic prosperity,lifestyle changes,accelerated process of ageing and urbanization.The prevalence of CVDs is continuously increasing in China and will remain an upward trend in the next 10 years.CVDs are the leading cause of death for Chinese in both urban area and rural area. | WANG Wen HU Sheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Yong Jun WU Zhao Su CHEN Wei Wei YANG Jin Gang MALi Yuan LIU Ming Bo For the editorial board | 2014 | Biomedical and Environmental Sciences2014，27，7： | 31 |
| 3 | The impact of minimally invasive surgeries for the treatment of symptomatic benign prostatic hyperplasia on male sexual function: a systematic review显示文摘使随机化的控制试用和队研究的系统的评论被进行在男性功能上为征兆的良性的 prostatic 增生(BPH ) 的处理为最低限度地侵略的过程的效果评估数据。寻找的研究是与征兆的 BPH 注册了人的试用与激光手术,经尿道的微波治疗( TUMT ),前列腺(金枪鱼)的经尿道的针脱离,前列腺( TEAP )的经尿道的乙醇脱离和高紧张的频率超声( HIFU )被对待,与前列腺( TURP )或假冒的操作的传统的经尿道的切除术比较。72 研究的一个总数被识别,哪个 33 满足了包括标准。33 研究, 21 涉及了激光手术,六与 TUMT,四与金枪鱼并且二与包含信息考虑的 TEAP 男性功能。没有学习关于为男性功能上的 BPH 的 HIFU 的效果是可得到的。我们的分析证明为 BPH 的最低限度地侵略的手术在男可勃起的功能上 TURP 有可比较的效果到那些。一起,分别地,不到 15.4% 病人或 15.2% 将在激光过程, TUMT 和金枪鱼以后可勃起的功能有减少或增加。是与 TURP 观察了,射精的机能障碍(EjD ) 的高发生在有钬, potassium-titanyl-phosphate 和铥激光治疗的 BPH 的治疗以后是普通的(>33.6%) 。TUMT,金枪鱼和 neodymium:yttrium 铝石榴石为 BPH 的视觉激光脱离或空隙的激光凝结有更少的发生 EjD,而是这些过程为 BPH 治疗被认为更少有效什么时候与 TURP 相比。 | Ryan W. Frieben Hao-Cheng Lin Peter E Hinh Francesco Berardinelli Steven E. Canfield Run Wang | 2010 | Asian Journal of Andrology2010，12，4： | 13 |
| 4 | Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence显示文摘我们的以前的学习显示出可勃起的设备(VED ) 治疗改进了的那真空在有双边的多孔的神经压碎(BCNC ) 的老鼠的可勃起的功能损害。这研究被设计由分析多孔的氧浸透在阴茎康复探索 VED 的机制(那么 2) 并且在在 BCNC 以后阻止阴茎收缩上检验 VED 治疗的效果。三十只成年 Sprague-Dawley 老鼠随机被分配进三个组:组织 1,假冒的外科;组织 2, BCNC;并且组织 3, BCNC+ VED。阴茎长度和直径在一个每周的基础上被测量。在 4 星期治疗以后,阴茎血被三个方法为血气体分析(BGA ) 提取:方法 1,多孔的血以松驰的状态被把发成送气音;方法 2,多孔的血以拖拉状态被把发成送气音;并且方法 3,多孔的血在使用 VED 以后立即被把发成送气音。2 价值被血气体分析器因此测试。结果证明那 VED 治疗在阻止 BCNC 导致的阴茎收缩是有效的(阴茎弄短:BCNC 组 1.9 ± 1.1 公里;VED 组 0.3 ± 1.0 公里;P< 0.01。阴茎直径减小:BCNC 组 0.28 ± 0.14 公里;VED 组 0.04 ± 0.14 公里;P< 0.01 ) 。2±s.d. 因此珍视的平均数被 VED 申请增加(88.25 % ± 4.94 %) 与相比松驰(76.53 % ± 4.16 %) 或拖拉组(78.93 % ± 2.56 %)(P< 0.05 ) 。在在 VED 申请以后的阴茎海绵体权利的计算的血构造是 62 %动脉并且 38 %静脉的血。这些调查结果建议那 VED 治疗能有效地与 BCNC 损害在老鼠保存阴茎尺寸。VED 治疗的有益的效果与由那么增加多孔的血的 antihypoxia 有关是 2 。 | Hao-Cheng Lin Wen-Li Yang Jun-Lan Zhang Yu-Tian Dai Run Wang | 2013 | Asian Journal of Andrology2013，15，3： | 9 |
| 5 | 勃起功能障碍(ED)的联合疗法显示文摘二十世纪九十年代末二十一世纪初,口服PDE5抑制剂(PDE5Is)的引入在很大程度上革新了性医学领域。目前PDE5I已经成为勃起功能障碍(ED)的首选单一疗法。然而,对一些复杂型ED患者来说,PDE5I单一疗法的疗效还不尽人意。目前越来越多不易治疗的ED病例开始采用联合疗法治疗,但还缺少对当前使用的联合疗法的严格评估。基于此,本综述在Pubmed和Cochrane Library数据库中进行了全面的文献检索.主要检索对象是1990年1月到2010年12月间研究PDE5I单一治疗失败后接受联合疗法的所有相关综述、随机对照试验、队列研究和回顾性研究。同时还对检索所得文献的参考文献进行了人工筛选,获得了其它一些相关的文献资料。目前发表的联合疗法主要包括PDE5I加真空吸引器(VED)、尿道给药、阴茎注射(ICI)、雄激素补充疗法、α-阻断剂,还有其它一些联合疗法。本综述发现,有些联合疗法的初步试验结果是有效的。然而,进行治疗时还是要谨慎,因为近十年来发表的大部分联合疗法相关文章的研究方法有很多问题,比如研究偏见和样本量小等。尽管如此,目前的研究结果还是在为将来复杂型ED的治疗研究方面奠定了坚实的基础。 | Rohit R Dhir Hao-Cheng Lin Steven E Canfield Run Wang | 2011 | Asian Journal of Andrology2011，13，3： | 7 |
| 6 | Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era显示文摘Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era. | ZHAO Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei GAO Li Jian GAO Zhan QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 7 | 内皮祖细胞的动员:糖尿病大鼠长期服用褪黑素预防勃起功能障碍的一个可能机制显示文摘糖尿病引起的氧化应激会对内皮祖细胞从骨髓中的动员产生重要影响。本文旨在探索长期给予褪黑素对提高I型糖尿病大鼠内皮祖细胞的动员作用,以及其对勃起功能障碍的预防功效。链脲佐菌素诱导的I型糖尿病大鼠被给予褪黑素。流式细胞术用于测定内皮祖细胞水平。骨髓组织中超氧化物歧化酶和丙二醛的水平用于反映骨髓组织中氧化应激水平。电刺激勃起神经记录海绵体内压力用于评价大鼠勃起功能。组织学评估阴茎海绵体组织中内皮密度及纤维化程度。结果显示长期给予褪黑素能够提高骨髓组织中超氧化物歧化酶的水平而降低丙二醛的水平,同时提高循环中内皮祖细胞的数量。治疗组大鼠海绵体内压和平均动脉压的比值较糖尿病对照组明显提高。组织学分析显示褪黑素治疗能够提高阴茎海绵体组织中内皮的密度。但是,褪黑素治疗并没有改善糖尿病大鼠阴茎海绵体组织中的纤维化状态。长期给予褪黑素对于保护I型糖尿病大鼠勃起功能具有一定的效果。改善内皮祖细胞的动员是可能的机制之一。 | Xue-Feng Qiu Xiao-Xin Li Yun Chen Hao-Cheng Lin Wen Yu Run Wang Yu-Tian Dai | 2012 | Asian Journal of Andrology2012，14，3： | 5 |
| 8 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 9 | THE p-VERSION OF FINITE ELEMENT METHODS FOR STEADY VISCOELASTIC FLOWS BETWEEN ECCENTRIC ROTATING CYLINDERS显示文摘The steady state, two dimensional creeping flow of an upper convected Maxwell (UCM) fluid between two eccentric cylinders, with the inner one rotating,is computed by p version of EVSS/SUPG finite element method. The solutions converge as the polynomial order of the approximation increases. An upper Deborah number (De) limit attains 30 (p≤5). With De increasing, The boundary layers form and develop in the stress, which match closely with those predicted by asymptotic analysis. The results show that numerical oscillations is caused by the boundary layers of stress and can be reduced by increasing the polynomial order of the approximation. | Lu Zhu min Department of Mechanics, Zhejiang University, Hangzhou 310027, P.R.China Wang Lin xiang State Key Laboratory for Fluid Power Transmission & Control, Zhejiang University, Hangzhou 310027, P.R.China Fan Yu run Department of Mechanics, | 1999 | Journal of Hydrodynamics1999，11，3： | 4 |
| 10 | The effects of long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via a local antioxidative mechanism显示文摘类型 5 phosphodiesterase 禁止者(PDE5Is ) 是众所周知的经由氮的氧化物和周期的 guanosine monophosphate (NO-cGMP ) 小径是有效的并且广泛地在糖尿病的可勃起的机能障碍(编辑) 的治疗被使用。然而,另外的小径是否可以与 PDE5Is 涉及糖尿病的编辑的处理,是不清楚的。这研究的目的是通过 PDE5Is 的长期的管理在糖尿病的编辑治疗澄清抗氧化剂的角色。三组 Sprague-Dawley 老鼠被利用:组 N,正常控制;组 D, streptozotocin (STZ ) 作为控制导致了糖尿病的老鼠;并且组织 D+ T,导致 STZ 的糖尿病的老鼠收到了 tadalafil 的口头的管理 8 个星期。可勃起的功能被 intracavernous 压力(ICP ) 和吝啬的动脉的压力(地图) 在无痛苦的死亡前在多孔的神经的电的刺激期间估计。malondialdehyde (MDA ) 的层次, superoxide dismutase (草皮) 和多孔的织物的 mitochondrial 膜潜力(MMP ) 被生物化学的分析估计。线粒体的形态学被电子显微镜学观察。ICP/MAP 比率在组 D+ 是更高的; T 比在组 D (P< 0.05 ) 。MDA 的层次减少了,草皮的活动在组 D+ 增加了;与组 D 比较的 T (P< 0.05 ) 。在糖尿病的老鼠的多孔的组织的 mitochondrial 膜潜力水平被 tadalafil 治疗部分恢复 8 个星期。线粒体的形态学变化显著地也在组 D+ 被改善; T。一起,在糖尿病的老鼠的 tadalafil 的长期的管理部分经由一条本地抗氧化的压力小径减少了阴茎的氧化压力损害。一旦每日的开始,在糖尿病的发作可以帮助阻止老鼠开发糖尿病的编辑后不久,给的 tadalafil 的长期的剂量。 | Yun Chen Xiao-Xin Li Hao-Cheng Lin Xue-Feng Qiu Jing Gao Yu-Tian Dai Run Wang | 2012 | Asian Journal of Andrology2012，14，4： | 4 |
| 11 | Microneedle-array patch with pH-sensitive formulation for glucoseresponsive insulin delivery显示文摘Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with diabetes.Herein,a new microneedle-array patch containing pH-sensitive insulin-loaded nanoparticles(NPs)(SNP(I))together with glucose oxidase(GOx)-and catalase(CAT)-loaded pH-insensitive NPs(iSNP(G+C))is constructed for transcutaneous glucose-responsive insulin delivery.SNP(I)are prepared via double emulsion from a pH-sensitive amphiphilic block copolymer,and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C)under hyperglycemic conditions.CAT in iSNP(G+C)can further consume excess H_(2)O_(2) generated during GOx oxidation,and thus reduce the risk of inflammation toward the normal skin.The in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period. | Feng-Qin Luo Guojun Chen Wei Xu Daojia Zhou Jia-Xian Li Yong-Cong Huang Run Lin Zhen Gu Jin-Zhi Du | 2021 | Nano Research2021，14，8： | 4 |
| 12 | 抗EGFR治疗转移性结直肠癌:耐药机制及潜在对策显示文摘作为表皮生长因子受体(EGFR)的高效靶向药物,西妥昔单抗和帕尼单抗常用于转移性结直肠癌(mCRC)患者的临床治疗。尽管这些药物取得良好的疗效,但耐药现象也常伴相随。目前,研究人员已经明确了KRAS、NRAS、BRAF突变以及HER2扩增对上述药物疗效的影响,并提出了相应的对策。但EGFR及其配体的异常,PIK3CA、PTEN、TP53、MET、HER3、IRS2、FGFR1和MAP2K1等基因的突变或扩增,胰岛素生长因子-1(IGF-1)的过表达,Bcl-2介导的细胞凋亡调节蛋白(Bim)的低表达,错配修复基因缺陷(dMMR),以及表观遗传不稳定等因素,也可导致mCRC的耐药。尽管耐药的出现具有遗传或表观遗传的异质性,但上述与此有关的分子改变大都集中在某些关键的信号通路上,如RAS/RAF/MAPK通路和PI3K/Akt/mTOR通路。因此,许多研究开始尝试靶向这些信号以期开发出新的治疗方案。本文中,我们对抗EGFR治疗耐药性的产生机制进行了综述,并提出了临床实践中的潜在对策。 | Qing-Hai Li Ying-Zhao Wang Jian Tu Chu-Wei Liu Yu-Jie Yuan Run Lin Wei-Ling He Shi-Rong Cai Yu-Long He Jin-Ning Ye | 2020 | Gastroenterology Report2020，8，3： | 3 |
| 13 | Testosterone replacement therapy and the risk of prostate cancer显示文摘 | Daniel Warburton Christopher Hobaugh Grace Wang Haocheng Lin Run Wang | 2015 | Asian Journal of Andrology2015，17，6： | 3 |
| 14 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 15 | Prospective and long-term evaluation of erect penile length obtained with inflatable penile prosthesis to that induced by intracavernosal injection显示文摘在有那的可膨胀的阴茎修复术(IPP ) 培植在外科前由 in-tracavernosal 注射(帝国化学工业公司) 导致了以后,我们比较了直立的阴茎长度。有充分勃起的 11 个病人的一个总数在阴茎颜色的时候由 Trimix (papaverine, phentolamine 和前列腺素 E1 ) 的 0.25 mL 的帝国化学工业公司导致了双 Doppler ultrasonography 在这研究被注册。病人随后为他们的可勃起的机能障碍(编辑) 作为最终的治疗经历了 IPP 培植。对 IPP 培植作为结果的直立的阴茎长度在 6 个星期被测量, 6 个月并且在在外科以后的 1 年。为男人(填隙用木片) 的性健康库存在 IPP 培植以后被管理在前,并且在 6 个月和 1 年。是导致了由树立阴茎长度(吝啬的 s.e ) 而与 IPP 达到的长度是 12.4,帝国化学工业公司是 13.2 0.4 厘米 0.3,在第六个星期,第六个月和 1 年的后续的 12.5 0.3 和 12.5 0.4 厘米分别地。有 0.83 0.25,分别地, 0.75 0.20 和 0.74 0.15 厘米在 IPP 培植以后在 6 个星期, 6 个月和 1 年在直立的阴茎长度减少什么时候与那相比在帝国化学工业公司以后(P < 0.05 ) 。没有抱怨,为报导更短的阴茎的病人的填隙用木片分数与为病人的那些一样(P > 0.05 ) 。到我们的知识,这是第一研究客观地在 IPP 培植以后在直立的阴茎长度看重要减少是否与那相比在帝国化学工业公司以后。然而,这减少没在对待编辑影响 IPP 的有效性。 | Run Wang Galen E Howard Anthony Hoang Jiu-Hong Yuan Hao-Cheng Lin Yu-Tian Dai | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 16 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 17 | Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population显示文摘Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P < 0.001), and rs3217986 G(P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders. | XU Jing Jing JIANG Lin XU Lian Jun GAO Zhan ZHAO Xue Yan ZHANG Yin SONG Ying LIU Ru SUN Kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，11： | 3 |
| 18 | 医源性男性尿失禁的手术治疗显示文摘前列腺外科手术、冷冻消融术、放射治疗以及尿道重建手术可导致医源性男性尿失禁(IMI),其中前列腺癌根治术是最常见的原因。IMI保守治疗方法有凯格尔训练和盆底肌肉电刺激等,而手术是有效的治疗方式,包括人工括约肌(AUS)植入术、球海绵体悬吊术、经尿道注射填充剂等。这些方法都是通过增加尿道阻力来达到治疗目的。AUS植入术被认为是前列腺切除术后尿失禁治疗的金标准,但它较高的并发症发生率和高昂的费用促使人们寻求更经济、更微创的治疗方法。 | ROMERO Claudio A LIN Hao-cheng WANG Run(撰文) 张林琳 曾津 贺大林(翻译) | 2011 | 现代泌尿外科杂志2011，16，1： | 3 |
| 19 | Risk or Beneficial Factors Associated with Unplanned Revascularization Risk Following Percutaneous Coronary Intervention: A Large Single-Center Data显示文摘Objective To analyze factors associated with unplanned revascularization(UR) risk in patients with coronary artery disease(CAD) who underwent percutaneous coronary intervention(PCI).Methods A total of 10,640 cases with CAD who underwent PCI were analyzed. Multivariate COX regressions and competing risk regressions were applied.Results The patients who underwent UR following PCI in 30 days, 1, and 2 years accounted for 0.3%,6.5%, and 8.7%, respectively. After multivariate adjustment, the number of target lesions [hazard ratio(HR) = 2.320;95% confidence interval(CI): 1.643–3.277;P < 0.001], time of procedure(HR = 1.006;95%CI: 1.001–1.010;P = 0.014), body mass index(HR = 1.104;95% CI: 1.006–1.210;P = 0.036), incomplete revascularization(ICR)(HR = 2.476;95% CI: 1.030–5.952;P = 0.043), and age(HR = 1.037;95% CI:1.000–1.075;P = 0.048) were determined as independent risk factors of 30-day UR. Factors, including low-molecular-weight heparin or fondaparinux(HR = 0.618;95% CI: 0.531–0.719;P < 0.001), secondgeneration durable polymer drug-eluting stent(HR = 0.713;95% CI: 0.624–0.814;P < 0.001), left anterior descending artery involvement(HR = 0.654;95% CI: 0.530–0.807;P < 0.001), and age(HR = 0.992;95%CI: 0.985–0.998;P = 0.014), were independently associated with decreased two-year UR risk. While,Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery score(HR =1.024;95% CI: 1.014–1.033;P < 0.001) and ICR(HR = 1.549;95% CI: 1.290–1.860;P < 0.001) were negatively associated with two-year UR risk.Conclusion Specific factors were positively or negatively associated with short-and medium-long-term UR following PCI. | LIU Ru GAO Zhan GAO Li Jian ZHAO Xue Yan CHEN Jue QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2020 | Biomedical and Environmental Sciences2020，33，6： | 2 |
| 20 | Meiotic nuclear divisions 1(MND1)fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma显示文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients. | Quanli Zhang Run Shi Yongkang Bai Lijuan Meng Jingwen Hu Hongyu Zhu Tongyan Liu Xiaomeng De Siwei Wang Jie Wang Lin Xu Guoren Zhou Rong Yin | 2021 | Cancer Communications2021，41，6： | 2 |
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