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| 1 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 2 | Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease:an update显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Niki Katsiki Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，，22： | 2 |
| 3 | Divergent reti- nal vascular abnormalities in normotensive persons and patients with never-treated, masked, white coat hypertension 显示文摘 | Triantafyllou A Doumas M Anyfanti P | 2013 | Am J Hypertens2013，26，3： | 1 |
| 4 | Divergent retinal vascular abnormalities in normotensive persons and patients with never-treated, masked, white coat hypertension 显示文摘 | Triantafyllou A Doumas M Anyfanti P | 2013 | Am J Hypertens2013，26，3： | 1 |
| 5 | Calibrating assays of direct bilirubin显示文摘 | Bland E Rosenthal P Doumas BT | 1991 | Clin Chem1991，37，1： | 1 |
| 6 | Use of proteome strategy for tagging proteins present at the plasma membrane显示文摘 | Santoni V Rouquie D Doumas P | 1998 | Plant J1998，16，： | 1 |
| 7 | Strategic alliances: Managing the dynamics of fit显示文摘 | Douma M U Bilderbeek J Idenburg P J | 2000 | Long Range Planning2000，33，4： | 1 |
| 8 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 9 | Divergent retinal vascular abnormalities in normotensive persons and patients with never-treated, masked, white-coat hypertension 显示文摘 | Triantafyllou A Doumas M Anyfanti P | 2013 | Am J Hypertens2013，26，3： | 1 |
| 10 | Strategic alliances:Managing the dynamics of fit 显示文摘 | Douma M U Bilberbeek J Idenburg P J | 2000 | Long Range Planning2000，，33： | 1 |
| 11 | Associations of fetuin-A and osteoprotegerin with arterial stiffness and early atherosclerosis in chronichemodialysis patients显示文摘 | Pateinakis P Papagianni A Douma S | 2013 | BMC Nephro12013，14，： | 1 |
| 12 | Heart rate recovery,exercise capacity,and mortality risk in male veterans显示文摘 | Kokkinos P Myers J Doumas M | 2012 | Eur J Prev Cardiol2012，19，2： | 1 |
| 13 | A randomised compar ision of int ravenous remifentanil patient-cont rolled analgesia with epidural ropivacaine/sufentanil during labour显示文摘 | Douma MR Middeldor p JM Ver wey R A | 2011 | Int J Obstet Anesth2011，20，2： | 1 |
| 14 | Endogenous cytokinins as biochemical markers of rubber-tree (Hevea brasiliensis) clone rejuvenation显示文摘 | Doumas P Lardet L | 1996 | Plant Cell Tissue and Organ Culture1996，47，3： | 1 |
| 15 | Strategie alliances : managing the dynamics of fit 显示文摘 | DOUMA M U BILDERBEEK J IDENBURG P J ET AL | 2000 | Long Range Planning2000，，33： | 1 |
| 16 | Strategic allianecs: Managing the dynamics of fit 显示文摘 | Douma M U Bilderbeek J Idenburg P J | 2000 | Long Range Planning2000，，4： | 1 |
| 17 | Large scale characterization of plant plasma membrane proteins 显示文摘 | Santoni V Doumas P Rouquie D et al | 1999 | Biochimie1999，81，6： | 1 |
| 18 | Use of a proteome strategy for tagging proteins present at the plasma membrane 显示文摘 | Santoni V Rouqui6 D Doumas P | 1998 | Plant J1998，16，5： | 1 |
| 19 | Strategic alliances:managing the dynamics of fit 显示文摘 | DOUMA M U BILDERBEEK J IDENBURG P J | 2000 | Longrange planning2000，，4： | 1 |
| 20 | Associations of fetuin-A and osteoprotegerin with arterial stiffness and early atherosclerosis in chronic hemodialysis patients显示文摘 | Pateinakis P Papagianni A Douma SA | 2013 | BMC Nephrol2013，14，1： | 1 |
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