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| 1 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 2 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 3 | Laboratory-simulated acid-sulfate weathering of basaltic materials:implications for formation of sulfates at meridiani planum and gusev crater,mars显示文摘 | Golden D C Douglas Ming W Richard Morris V | 2005 | Journal of Geophysical Research E Planets2005，110，12： | 1 |
| 4 | A theory of production 显示文摘 | Cobb C W Douglas P H | 1928 | American Economic Review1928，，1： | 1 |
| 5 | Primary structure of the Aecquorea Victoria green fluorescent protein 显示文摘 | Douglas C P Virginia K Wiliam W W | 1992 | Gene1992，111，2： | 1 |
| 6 | 显示文摘 | PILIEGO C HOLCOMBE T W DOUGLAS J D | 2010 | J Am Chem Soc2010，132，22： | 1 |
| 7 | Identity of viridans streptococci isolated from cases of infective endocarditis 显示文摘 | DOUGLAS C W HEATH J HAMPTON K K | 1993 | J Med Microbiol1993，39，3： | 1 |
| 8 | Nutritional evaluation of lectin-free soybeans for poultry 显示文摘 | Douglas M W Parsons C M Hymowitz T | 1999 | Pouh Sci1999，78，： | 1 |
| 9 | A theory of production显示文摘 | COBB C W DOUGLAS P H | 1928 | American E- conomic Review1928，，18： | 1 |
| 10 | Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-D/L-Val sequence in Gram-positive and Gram-negative bacteria显示文摘 | CHARNLEY M MOIR A J DOUGLAS C W | 2008 | Peptides2008，29，6： | 1 |
| 11 | :The Economic Theory of Index Numbers and the Measurement of Input,Output and Productivity显示文摘 | DOUGLAS W C | 1982 | Econometrics1982，50，6： | 1 |
| 12 | A Theory of Production显示文摘 | COBB C W DOUGLAS P H | 1928 | The American Economic Review1928，，： | 1 |
| 13 | Leader Political Skill and Employee Reactions 显示文摘 | Treadway D C Hochwarter W A Ferris G R Kacmar C J Douglas C Ammeter A P Buckley M R | 2004 | The Leadership Quarterly2004，15，4： | 1 |
| 14 | Inhibitory effect of gar- lic extract on oral bacteria 显示文摘 | BAKRI I M DOUGLAS C W I | 2005 | Archives of 0ral Biology2005，50，7： | 1 |
| 15 | Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes显示文摘 | Shimareet Kumar Lazlo Krenacs Jeffrey Medeiros Kojo S.J Elenitoba-Johnson Timothy C Greiner Lynne Sorbara Douglas W Kingma Mark Raffeld Elaine S Jaffe | 1998 | Human Pathology1998，，4： | 1 |
| 16 | A Theory of production显示文摘 | Cobb C W Douglas P H | 1928 | The American Economic Review1928，18，1： | 1 |
| 17 | Orientationorder in block copolymer films zone annealedbelow the order-disorder transition temperature 显示文摘 | BERRY B C BOSSE A W DOUGLAS J F | 2007 | Nano Letters-2007，7，： | 1 |
| 18 | A theory of production 显示文摘 | Cobb C W and Douglas P H | 1928 | American Economic Review1928，18，： | 1 |
| 19 | The Impact of Cognitive Expenditure on the Ethical Decision - Making Process: The Cognitive Elaboration Model 显示文摘 | Street M D Douglas S C Geiger S W | 2001 | Organizational Behavior and Human Decision Processes2001，86，2： | 1 |
| 20 | Analysis of high molecular-mass polycyclic aromatic hydrocarbons in environmental samples using liquid-chromatography-atmospheric pressure chemical ionization mass spectrometry 显示文摘 | Marvin C H Richard W Smith Douglas W Bryant | 1999 | Journal of Chromatography A1999，863，： | 1 |
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