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| 1 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006,12,29: | 5 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002,,6: | 3 |
| 3 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011,,9790: | 2 |
| 4 | Difference in dietary intake between women with polycystic ovary syndrome and healthy controls 显示文摘 | Douglas C C Norris L E Oster R A | 2006 | Fertil Steril2006,86,2: | 1 |
| 5 | Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and re- generation显示文摘 | All Z A Rinze R Douglas G | 2013 | Circulation2013,128,111: | 1 |
| 6 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008,,4: | 1 |
| 7 | Environmentalstability of selected petroleum hydrocarbon source and weatheringratios显示文摘 | Douglas G S Bence A E Prince R C | 1996 | Environmental Science&Technology1996,30,7: | 1 |
| 8 | Multicriteria optimization with a multiobjective golden section line search显示文摘 | Douglas A G V Ricardo H C T Rodney R S | 2012 | Mathematical Programming2012,131,12: | 1 |
| 9 | Spinodal dewetting of thin polymer films 显示文摘 | Xie R Karim A Douglas J F Han C C Weiss R A | 1998 | Physical Review Letters1998,81,: | 1 |
| 10 | Crown profile models based on branch attributes in coastal Douglas-fir显示文摘 | RANDY L R DOUGLAS A M | 1997 | For Ecol and Manage1997,96,: | 1 |
| 11 | Fecal calprotectin levels predict colorectal inflammation among patients with chronic diarrhea referred for colonoscopy显示文摘 | Paul J Limburg David A Ahlquist William J Sandborn Douglas W Mahoney Mary E Devens Jonathan J Harrington Alan R Zinsmeister | 2000 | The American Journal of Gastroenterology2000,,10: | 1 |
| 12 | Ballistic magnetoresistance in nickel single-atom conductorswithout magnetostriction显示文摘 | Sullivan Matthew R Boehm Douglas A Ateya Daniel A | 2005 | Phys Rev B2005,71,: | 1 |
| 13 | The functional gastrointestinal disorders and the Rome III process显示文摘 | Douglas A Drossman R | 2006 | Gastroenterolo- gy2006,130,5: | 1 |
| 14 | The peroxisome proliferator-activated receptor-γ2 Pro12Ala variant:association with type 2 diabetes and trait differences 显示文摘 | Douglas J A Erdos M R Waranabe R M | 2001 | Diabetes2001,50,: | 1 |
| 15 | Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury显示文摘 | Medford A R L Douglas S K Godinho S I H | 2009 | Respiratory Research2009,10,1: | 1 |
| 16 | Speaker Verification Using Adapted Gaussian Mixture Models显示文摘 | Douglas A R Thomas F Q Robert B D | 2000 | Digital Signal Processing2000,10,13: | 1 |
| 17 | Electroantenno- gram responses of Hyles lineate (Sphingidae: Lepidoptera) to volatiles from Clarkia breweri (Onagraceae) and other moth-pollinated 显示文摘 | ROBERT A R DOUGLAS M L ERAN P | 1996 | Journal o{ Chemical Ecology1996,22,10: | 1 |
| 18 | Radioactive properties of high wire number tungsten arrays with implosion times up to 250ns显示文摘 | Deeney C Coverdale C A Douglas M R | 1999 | Phys Plasma1999,6,9: | 1 |
| 19 | A Study of the Tribological Behaviour of Piston Ring/cylinder Liner Interaction in Diesel Engines Using Acoustic Emission显示文摘 | Douglas R M Steel J A Reuben R L | 2006 | Tribology International2006,39,: | 1 |
| 20 | Three-dimen-sional structure of an antigenic mutant of the influenza virushemagglutinin显示文摘 | Knossow M Daniels R S Douglas A R | 1984 | Nature1984,311,5987: | 1 |