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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Positive Solutions to Singular Boundary Value Problems with Sign Changing Nonlinearities on the Half-Line via Upper and Lower Solutions显示文摘This paper presents a lower and upper solution technique for singular second order boundaryvalue problems on the half line. | Bao Qiang YAN Donal O'REGAN Ravi P. AGARWAL | 2007 | Acta Mathematica Sinica,English Series2007，23，8： | 5 |
| 3 | Chronic pancreatitis:A diagnostic dilemma显示文摘Typical clinical symptoms of chronic pancreatitis are vague and non-specific and therefore diagnostic tests are required, none of which provide absolute diagnostic certainly, especially in the early stages of disease. Recently-published guidelines bring much needed structure to the diagnostic work-up of patients with suspected chronic pancreatitis. In addition, novel diagnostic modalities bring promise for the future. The assessment and diagnosis of pancreatic exocrine insufficiency remains challenging and this review contests the accepted perspective that steatorrhea only occurs with > 90% destruction of the gland. | Sinead N Duggan Hazel M NíChonchubhair Oladapo Lawal Donal B O’Connor Kevin C Conlon | 2016 | World Journal of Gastroenterology2016，22，7： | 4 |
| 4 | An Upper and Lower Solution Theory for the Problem(G′(y))′+f(t,y)=0 on Finite and Infinite Intervals显示文摘A new upper and lower solution theory is presented for the second order problem(G'(y))'+f(t,y)=0 on finite and infinite intervals.The theory on finite intervals is based on a Leray-Schauderalternative,whereas the theory on infinite intervals is based on results on the finite interval and adiagonalization process. | Ravi P.AGARWAL Donal O'REGAN Svatoslav STANEK | 2006 | Acta Mathematica Sinica,English Series2006，22，3： | 2 |
| 5 | 一个分数阶方程组积分边值问题的正解(英文)显示文摘本文研究一个分数阶方程组积分边值问题.利用不动点指数方法,采用非负凹凸函数刻画非线性项间的耦合行为,并借助单调有界原理,获得该问题正解的存在性结果,并构造了近似解的迭代序列,推广和完善了已有的一些结果. | 程伟 徐家发 Donal O’Regan | 2018 | 应用数学2018，31，2： | 2 |
| 6 | Unlocking quality in endoscopic mucosal resection显示文摘A review of the development of the key performance metrics of endoscopic mucosal resection(EMR),learning from the experience of the establishment of widespread colonoscopy quality measurements.Potential future performance markers for both colonoscopy and EMR are also evaluated to ensure continued high quality performance is maintained with a focus service framework and predictors of patient outcome. | Eoin Keating Jan Leyden Donal B O'Connor Conor Lahiff | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 2 |
| 7 | Prognostic significance of detection of microscopic peritoneal disease in colorectal cancer: A systematic review显示文摘 | Helen M. Mohan Donal B. O’Connor James M. O’Riordan Des C. Winter | 2013 | Surgical Oncology2013，，： | 2 |
| 8 | The extinction and persistence of the stochastic SIS epidemic model with vaccination显示文摘 | ZHAO Yanan JIANG Daqing O'Regan Donal | 2013 | Physica A Statistical Mechanics and its Applications2013，392，： | 1 |
| 9 | Positive solution for singular p-Laplaeian equations with sign-changing nonlinearities using inequality theory显示文摘 | LU Hai-shen DONAL O' Regan RAVI P Agarwal | 2005 | Applied Mathematics and Computation2005，165，3： | 1 |
| 10 | A Prospective Study of Common Bile Duct Calculi in Patients Undergoing Laparoscopic Cholecystectomy: Natural History of Choledocholithiasis Revisited显示文摘 | Chris Collins Donal Maguire Adrian Ireland Edward Fitzgerald Gerald C. O'Sullivan | 2004 | Annals of Surgery2004，，1： | 1 |
| 11 | Multiple positive solutions for the one-dimensional singular p-Laplacian显示文摘 | LV H S Donal O' Regan Zhong C K | 2002 | Applied Mathematics and Computation2002，133，： | 1 |
| 12 | Existence and uniqueness of positive solutions for fourth-order nonlinear singular continuous and discrete boundary value problems显示文摘 | Yuan Chengjun Jiang Daqing O' Regan Donal | 2008 | Applied Mathematics and Computation2008，203，： | 1 |
| 13 | Corneal Hysteresis and Corneal Resistance Factor in Keratoectasia: Findings Using the Reichert Ocular Response Analyzer显示文摘 | Kirwan Caitriona O'malley Donal O'keefe Michael | 2008 | Ophthalmologica2008，，5： | 1 |
| 14 | Some fixed point theorems for concentrative mappings between locally convex linear topological spaces显示文摘 | Donal O'Regan | 1996 | Nonlinear analysis theory methods applications1996，27，12： | 1 |
| 15 | Oscillation of second-order damped dynamic equations on time scales显示文摘 | Samir H. Saker Ravi P. Agarwal Donal O’Regan | 2006 | Journal of Mathematical Analysis and Applications2006，，2： | 1 |
| 16 | The periodic boundary value problem for semilinear elastic beam equations : The resonance case显示文摘 | CHEN Jin-hai O' REGAN Donal | 2007 | Computers & Mathematics with Applications2007，53，8： | 1 |
| 17 | Existence of positive solutions for singular initial and boundary value problems via the classical upper and lower solution approach显示文摘 | Agarwal R P Donal O'Regan Lakshmikantham V | 2002 | Nonlinear Anal2002，50，： | 1 |
| 18 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 19 | Emergency planning and the Control of Major Accident Hazards ( COMAH/Seveso Ⅱ) Directive: An approach to determine the public safety zone for toxic cloud releases 显示文摘 | MARY T MAHONY O DONAL D | 2008 | Journal of Hazardous Materials2008，154，13： | 1 |
| 20 | Some fixed point theorems for concentrative mapping between locally convex linear topological spaces 显示文摘 | | 1996 | Nonlinear Analysis1996，27，12： | 1 |
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