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| 1 | Type 2 diabetes mellitus and Alzheimer's disease显示文摘Epidemiological and biological evidences support a link between type 2 diabetes mellitus(DM2) and Alzheimer's disease(AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the areas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after controlling for diabetic vascular disease and inadequate cerebral circulation. Most recent studies have focused on the role of insulin and insulin resistance as possible links between diabetes and AD. Disturbances in brain insulin signaling mechanisms may contribute to the molecular, biochemical, and histopathological lesions in AD. Hyperglycemia itself is a risk factor for cognitive dysfunction and dementia. Hypoglycemia may also have deleterious effects on cognitive function. Recurrent symptomatic and asymptomatic hypoglycemic episodes have been suggested to cause sub-clinical brain damage, and permanent cognitive impairment. Futuretrials are required to clarify the mechanistic link, to address the question whether cognitive decline may be prevented by an adequate metabolic control, and to elucidate the role of drugs that may cause hypoglycemic episodes. | Mario Barbagallo Ligia J Dominguez | 2014 | World Journal of Diabetes2014，5，6： | 22 |
| 2 | Increased postoperative complications after protective ileostomy closure delay: An institutional study显示文摘AIM: To study the morbidity and complications as-sociated to ileostomy reversal in colorectal surgery pa-tients, and if these are related to the time of closure. METHODS: A retrospective analysis of 93 patients, who had undergone elective ileostomy closure between 2009 and 2013 was performed. Demographic, clinical and surgical variables were reviewed for analysis. All complications were recorded, and classified according to the Clavien-Dindo Classification. Statistical univariate and multivariate analysis was performed, setting a P value of 0.05 for significance.RESULTS: The patients had a mean age of 60.3 years, 58% male. The main procedure for ileostomy cre-ation was rectal cancer(56%), and 37% had received preoperative chemo-radiotherapy. The average delay from creation to closure of the ileostomy was 10.3 mo. Postoperative complications occurred in 40% of the pa-tients, with 1% mortality. The most frequent were ileus(13%) and wound infection(13%). Pseudomembra-nous colitis appeared in 4%. Increased postoperative complications were associated with delay in ileostomyclosure(P = 0.041). Male patients had more complica-tions(P = 0.042), mainly wound infections(P = 0.007). Pseudomembranous colitis was also associated with the delay in ileostomy closure(P = 0.003). End-to-end in-testinal anastomosis without resection was significantly associated with postoperative ileus(P = 0.037). CONCLUSION: Although closure of a protective il-eostomy is a fairly common surgical procedure, it has a high rate of complications, and this must be taken into account when the indication is made. The delay in stoma closure can increase the rate of complications in general, and specifically wound infections and colitis. | Ines Rubio-Perez Miguel Leon Daniel Pastor Joaquin Diaz Dominguez Ramon Cantero | 2014 | World Journal of Gastrointestinal Surgery2014，6，9： | 11 |
| 3 | 兆瓦级风力发电机组有功功率调节综述(英文)显示文摘大型兆瓦级风力发电机是近年来风电机组的发展趋势,其控制系统变得越来越重要,对其的设计要求也变得越来越苛刻。此外,对风电机组的性能和结构性载荷都取决于对控制器的认识为风电机组的研究带来的新动力。将控制器的任务扩展到减轻结构性载荷激励了对寻求新的利用叶片节距系统来使结构性载荷的减轻最大化的控制策略的探究。为了加强对用于兆瓦级风电机组的控制的可能性和潜力的认识,文章对其进行了概要介绍,并讨论了控制系统在风能技术中的地位及其作为一种综合了开发者的洞察力的技术的作用。 | William E.Leithead Sergio Dominguez | 2007 | 电网技术2007，31，20： | 8 |
| 4 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 5 | Magnesium and type 2 diabetes显示文摘Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium(Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulinand glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profiles in diabetic patients have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. The aim of this review is to revise current evidence on the mechanisms of Mg deficiency in diabetes and on the possible role of Mg supplementation in the prevention and management of the disease. | Mario Barbagallo Ligia J Dominguez | 2015 | World Journal of Diabetes2015，6，10： | 4 |
| 6 | The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells显示文摘 | Alice Cristina RODRIGUES Rui CURI Fabiana Dalla Vecchia GENVIGIR Mario Hiroyuki HIRATA Rosario Dominguez Crespo HIRATA | 2009 | Acta Pharmacologica Sinica2009，30，7： | 4 |
| 7 | Presacral venous bleeding during mobilization in rectal cancer显示文摘AIM To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal cancer.METHODS A review of the databases MEDLINE? and Embase? was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were defined.RESULTS This is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious complication.CONCLUSION A series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications. | Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 8 | Adsorption of NO on Activated Carbon: Equilibrium and Energetic Interactions显示文摘 | Rosario Hernandez-Huesca Gelacio Aguilar-Armenta Gerardo Dominguez | 2010 | 材料科学与工程(中英文版)2010，4，4： | 3 |
| 9 | Perforated duodenal diverticulum, a rare complication of a common pathology: A seven-patient case series显示文摘Duodenal diverticula (DD) are frequently encountered and are usually asymptomatic, with an incidence at autopsy of 22%. Perforation of DD is a rare complication (around 160 cases reported) with potentially dramatic consequences. However, little evidence regarding its treatment is available in the literature. The aim of this study was to review our experience of perforated DD, with a focus on surgical management. Between January 2001 and June 2011, all perforated DD were retrospectively reviewed at a single centre. Seven cases (5 women and 2 men; median age: 72.4 years old, rang: 48-91 years) were found. The median American Society of Anesthesiologists' score in this population was 3 (range: 3-4). The perforation was located in the second portion of duodenum (D2) in six patients and in the third portion (D3) in one patient. Six of these patients were treated surgically: five patients underwent DD resection with direct closure and one was treated by surgical drainage and laparostomy. One patient was treated conservatively. One patient died and one patient presented a leak that was successfully treated conservatively. The median hospital stay was 21.1 d (range: 15-30 d). Perforated DD is an uncommon presentation of a common pathology. Diverticular excision with direct closure seems to offer the best chance of survival and was associated with a low morbidity, even in fragile patients. | Andrea Rossetti Nicolas Christian Buchs Pascal Bucher Stephane Dominguez Philippe Morel | 2013 | World Journal of Gastrointestinal Surgery2013，5，3： | 3 |
| 10 | Quantitative Endoscopic Ultrasound Elastography: An Accurate Method for the Differentiation of Solid Pancreatic Masses显示文摘 | Julio Iglesias–Garcia Jose Larino–Noia Ihab Abdulkader Jeronimo Forteza J. Enrique Dominguez–Munoz | 2010 | Gastroenterology2010，，4： | 3 |
| 11 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 12 | A single subcutaneous dose of tramadol for mild to moderate musculoskeletal trauma in the emergency department显示文摘BACKGROUND: Mild to moderate musculoskeletal trauma is a common cause for an emergency room visit, and frequent pain is one of the cardinal symptoms of consultation. The objective of this study is to assess the perception of a single subcutaneous dose of 50 mg tramadol for pain management in patients with mild to moderate musculoskeletal trauma, likewise to appraise the perception of pain by subcutaneous injection.METHODS: A total of 77 patients, who met inclusion criteria, received a single subcutaneous dose of tramadol. Pain control was evaluated based on the verbal numerical pain scale(0–10) at baseline, 20 and 60 minutes; similarly, pain perception was evaluated secondary to subcutaneous injection of the analgesic.RESULTS: On admission, the average pain perceived by patients was 8; twenty minutes later, 89% of the patients reported fi ve or less, and after sixty minutes, 94% had three or less on the verbal numerical pain scale. Of the patients, 88% reported pain perception by verbal numeric scale of 3 or less by injection of the drug, and 6.5% required a second analgesic for pain control. Two events with drug administration(soft tissue infection and mild abdominal rectus injection) were reported.CONCLUSION: We conclude that a single subcutaneous dose of tramadol is a safe and effective option for the management of patients with mild to moderate pain and musculoskeletal disease in the emergency department. | Alejandro Cardozo Carlos Silva Luis Dominguez Beatriz Botero Paulo Zambrano Jose Bare?o | 2014 | World Journal of Emergency Medicine2014，5，4： | 2 |
| 13 | Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina显示文摘AIM To study the prevalence, characteristics, risk factors and mortality at 28 d of acute-on-chronic liver failure(ACLF).METHODS A total of 100 cirrhotic patients admitted to our hospital for more than one day were included during the period between June 2013 and December 2015. We used the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria for ACLF, considering it as the acute decompensation of cirrhosis associated with the presence of one or more organ failure. For the diagnosis of organic failure the Chronic Liver Failure-Sequential Organ Failure Assessment score was used. Our population was divided into patients with and without ACLF. Clinical characteristics, presence of precipitating events, potential risk factors for developing ACLF and causes of mortality were analyzed. Mortality at 28 d was evaluated.RESULTS Twenty-nine patients(29%) developed ACLF criteria. Alcoholism, detected in 58 patients(58%), was the major etiological agent of cirrhosis. Bacterial infections were recognized as a precipitating event in 41.3% of cases and gastrointestinal bleeding in 27.5%. No precipitating event was identifiable in 27.5% of patients with ACLF. Comparing patients with and without ACLF, statistically significant risk factors were: Child Pugh score 10.2 ± 2.1 vs 8.4 ± 1.6(P < 0.0001), MELD score 20.7 ± 8.5 vs 12.3 ± 4(P < 0.0001), presence of ascites 27(93%) vs 43(60.5%)(P = 0.001), leukocytosis 15300 ± 8033 per cubic millimeter vs 10770 ± 5601 per cubic millimeter(P < 0.0001), and high plasma levels of C reactive protein values 50.9 ± 46.4 mg/L vs 28.6 ± 23.4 mg/L(P < 0.0019). Mortality rate was 62%(18 patients) vs 5.6%(4 patients), respectively(P < 0.0001).CONCLUSION We observed that the ACLF is a frequent entity in this group of patients and has a significantly higher mortality rate. | Cristian Dominguez Eugenia Romero Jorgelina Graciano Jose Luis Fernandez Luis Viola | 2016 | World Journal of Hepatology2016，8，34： | 2 |
| 14 | Oncotarget:新型免疫疗法药物组合或可有效治疗癌症显示文摘2016年6月21日,刊登于国际杂志《Oncotarget》上的一项研究论文中,来自梅奥诊所的研究人员通过研究开发了一种新型药物组合,可以增强机体免疫系统精确狙击杀灭癌细胞的能力,这种新型药物组合或许可以在治疗小鼠机体恶性癌症及转移性癌症上具有一定的治疗效应。 | Manrique SZ Dominguez AL Mirza N | 2016 | 疾病监测2016，31，7： | 2 |
| 15 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 16 | Circulating cellular and humoral elements of immune function following splenic arterial embolisation or splenectomy in trauma patients显示文摘 | Mbaga S. Walusimbi Kathleen M. Dominguez Jean M. Sands Ronald J. Markert Mary C. McCarthy | 2011 | Injury2011，，2： | 2 |
| 17 | Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America显示文摘 | Javier Torres Pelayo Correa Catterina Ferreccio Gustavo Hernandez-Suarez Rolando Herrero Maria Cavazza-Porro Ricardo Dominguez Douglas Morgan | 2013 | Cancer Causes & Control2013，，2： | 2 |
| 18 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 19 | Validity of a modified 13C-urea breath test for pre- and posttreatment diagnosis of Helicobacterpylori infection in the routine clinical setting显示文摘 | Leodolter A Dominguez Munoz JE von Amim U | 1999 | Am J Gastroenterol1999，94，： | 2 |
| 20 | CT-scan vs.3D surface scanning of a skull:first considerations regarding reproducibility issues显示文摘Three-dimensional surface scanning(3DSS)and multi-detector computed tomography(MDCT)are two techniques that are used in legal medicine for digitalizing objects,a body or body parts such as bones.While these techniques are more and more commonly employed,surprisingly little information is known about the quality rendering of digitalized three-dimensional(3D)models provided by each of them.This paper presents findings related to the measurement precision of 3D models obtained through observation of a study case,where a fractured skull reconstructed by an anthropologist was digitalized using both post-mortem imaging methods.Computed tomography(CT)scans were performed using an 8-row MDCT unit with two different slice thicknesses.The variability of 3D CT models superimposition allowed to assess the reproducibility and robustness of this digitalization technique.Furthermore,two 3D surface scans were done using a professional high resolution 3D digitizer.The comparison of 3D CT-scans with 3D surface scans by superimposition demonstrated several regions with significant differences in topology(average difference between+1.45 and-1.22 mm).When comparing the reproducibility between these two digitalizing techniques,it appeared that MDCT 3D models led in general to greater variability for measurement precision between scanned surfaces.Also,the reproducibility was better achieved with the 3D surface digitizer,showing 3D models with fewer and less pronounced differences(from+0.32 to-0.31 mm).These experiments suggest that MDCT provides less reproducible body models than 3D surface scanning.But further studies must be undertaken in order to corroborate this first impression,and possibly explain the reason for these findings. | Stella Fahrni Lorenzo Campana Alejandro Dominguez Tanya Uldin Fabrice Dedouit Olivier Deleemont Silke Grabherr | 2017 | Forensic Sciences Research2017，2，2： | 2 |
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