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| 1 | Hepatitis C virus infection in children in the era of directacting antiviral显示文摘Hepatitis C virus(HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral(DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C. | Malgorzata Pawlowska Malgorzata Sobolewska-Pilarczyk Krzysztof Domagalski | 2018 | World Journal of Gastroenterology2018，24，24： | 8 |
| 2 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 3 | Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp: Phosphorus dynamics显示文摘This is the third paper of the series about 'Dynamics of algae growth and nutrients in experimental enclosures culturing bighead carp and common carp'.In this paper,phosphorus dynamics were investigated under the condition of culturing bighead carp and common carp with added fish food(nitrogen dynamics is discussed in the second paper because their behaviors are so different from each other).Nearly fifty days' observation results indicated that the reservoir water was typical of 'phosphorus limited' water,and soluble reactive phosphorus(SRP) was the main constituent of measured total phosphorus(TP).The presence of fish food resulted in significantly higher SRP,dissolved total phosphorus(DTP) and TP concentrations in contrast with the reservoir water.Moreover,continuous supply of fish food led to the decline of total nitrogen to total phosphorus(TN:TP) from more than 100 to less than5.Variations in the ratio of TN to TP favored the growth of blue-green algae.Fish species affected phosphorus concentrations,and culturing bait-eating common carp contributed more to reducing the SRP,DTP and TP concentrations than culturing planktivorous bighead carp.0.5%,4.1%and 3.1%TP can be removed in enclosures with culturing bighead carp,common carp and mixed bighead carp and common carp,respectively.Abundant phosphorus in the fish culturing activities may be present as the uneaten food,algae cells,and within the water column and sediment,which should be taken into serious consideration for the target of future water eutrophication prevention and safety of the drinking water supply. | Suiliang Huang Min Wu Changjuan Zang Shenglan Du Joseph Domagalski Magdalena Gajewska Feng Gao Chao Lin Yong Guo Baoyan Liu Shaoming Wang Yang Luo Adam Szymkiewicz Romuald Szymkiewicz | 2016 | International Journal of Sediment Research2016，31，2： | 3 |
| 4 | What's new in hepatitis C virus infections in children?显示文摘The number of hepatitis C virus(HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently,mother-toinfant transmission is the most common cause of HCV infection amongst children in developed countries. It is important to introduce routine screening tests for HCV in pregnant women. The risk of vertical transmission of HCV is estimated at approximately 5%(3%-10%). Currently,we do not have HCV transmission prevention methods. Some factors could potentially be eliminated by elective caesarean section. Currently,the method of prevention of perinatal HCV infection is the early identification and effective treatment of infections in young women in the preconception period. We describe genetic tests(IL-28 B single nucleotide polymorphisms) to identify children with an increased chance of spontaneous clearance or sustained virologic response achievement and vitamin D level as a potential predictor of treatment response in children. It is also important to develop non-invasive tests that can predict liver fibrosis. The existence of differences in the mechanisms leading to liver injury between children and adults creates new perspectives of action to reduce liver disease progression in children in the early years of life. | Malgorzata Pawlowska Krzysztof Domagalski Anna Pniewska Beata Smok Waldemar Halota Andrzej Tretyn | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 5 | Ecological risk of heavy metals in sediments of the Luan River source water显示文摘 | Jingling Liu Yongli Li Bao Zhang Jinling Cao Zhiguo Cao Joseph Domagalski | 2009 | Ecotoxicology2009，，6： | 2 |
| 6 | Ecological risk of heavy metals in sediments of the Luan River source water显示文摘 | Jingling Liu Yongli Li Bao Zhang Jinling Cao Zhiguo Cao Joseph Domagalski | 2009 | Ecotoxicology2009，，6： | 1 |
| 7 | Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4显示文摘 | K. Domagalski M. Paw?owska A. Tretyn W. Halota M. Pilarczyk E. Smukalska K. Linkowska T. Grzybowski | 2013 | European Journal of Clinical Microbiology & Infectious Diseases2013，，6： | 1 |
| 8 | Eutrophication study at the Panjiakou-Daheiting Reservoir system, northern Hebei Province, People's Republic of China: Chlorophyll-a model and sources of phosphorus and nitrogen 显示文摘 | JOSEPH DOMAGALSKI CHAO LIN YANG LUO | 2007 | Agricultural Water Management2007，94，： | 1 |
| 9 | Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary显示文摘 | Balvers M Spiess AN Domagalski R | 1998 | Endocrinology1998，139，6： | 1 |
| 10 | Distribution of pesticides and organic contaminants between water and suspended sediment,San Francisco Bay,California显示文摘 | DOMAGALSKI J L KUIVILA K M | 1993 | Estuaries1993，16，3： | 1 |
| 11 | Occurrence of dicofol in the San Joaquin River, California 显示文摘 | Domagalski J | 1996 | Bulletin of Environmental Contamina- tion and Toxicology1996，57，2： | 1 |
| 12 | Eutrophication study at the Panjiakou-Daheiting reservoir system,northern Hebei province,people's republic of China:Chlorophyll-a model and sources of phosphorus and nitrogen显示文摘 | Domagalski J Lin C Luo Y | 2007 | Agricultural Water Management2007，94，13： | 1 |
| 13 | Emotion in Organizations: Main Currents 显示文摘 | Domagalski T A | 1999 | Human Relations1999，52，： | 1 |
| 14 | Eutrophication study at the Panjiakou-Daheiting reservoir system,northern Hebei province,people's republic of China:Chlorophyll-a model and sources of phosphorus and nitrogen显示文摘 | Domagalski J Lin C Luo Y | 2007 | Agricultural Water Management2007，94，13： | 1 |
| 15 | Eutrophication study at the Panjiakou-Daheiting Reservoir system, northern Hebei province, People' s Republic of China: Chlorophyll-a model and sources of phosphorus and nitrogen显示文摘 | Domagalski J Lin C Luo Y | 2007 | Agricultural Wa- ter Management2007，94，13： | 1 |
| 16 | Relaxin-like factor as a marker of differentiation in the mouse testis and ovary显示文摘 | Balvers M Spiess AN Domagalski R | 1998 | Endocrinology1998，139，6： | 1 |
| 17 | Distribution of pesticides and organic contaminants between water and suspended sediment, San Francisco Bay, California 显示文摘 | Domagalski J L Kuivila K M | 1993 | Estuaries1993，16，3： | 1 |
| 18 | Analysis of relative expression level of VEGF(vascular endothelial growth factor),HIF-1α(hypoxia inducible factor 1α)and CTGF(connective tissue growth factor)genes in chronic glomerulonephritis(CGN)patients显示文摘 | Donderski R Szczepanek J Domagalski K | 2013 | Kidney Blood Press Res2013，38，1： | 1 |
| 19 | Occurrence and accumulation of pesticides and organic contaminants in river sediment, water and clam tissues from the San, Joaquin river and tributaries, California显示文摘 | PIERARD W E DOMAGALSKI J L HOSTETTLER F D | 1996 | Environment Toxicity Chemical1996，15，： | 1 |
| 20 | Nulls for the major soybean Bowman-Birk proteasc inhibitor in the genus Glycine显示文摘 | Domagalski J M Kollipara K P Bates A H | 1992 | Crop Science1992，32，6： | 1 |
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