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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | A mitochondria- specific visible-light sensitized europium β-diketonate complex with red emission 显示文摘 | DIVYA V SANKAR V RAGHU K G | 2013 | Dalton Transactions2013，42，12： | 1 |
| 3 | Colonization ofprobiotic iDacteria and its impact on ornamental fish Puntius conchonius显示文摘 | DIVYA KR ISAMMA A RAMASUBRAMANIAN V | 2012 | J Environ Biol2012，33，3： | 1 |
| 4 | Cloning and characterization of truncated crylAb gene from a new in- digenous isolate of Bacillus thuringiensis 显示文摘 | Darsi S Divya Prakash G Udayasuriyan V | 2010 | Biotechnol Lett2010，32，9： | 1 |
| 5 | Synthesis, characterization, cytotoxicity and antibacterial studies of chi- tosan, O-carboxymethyl and NO-carboxymethyl chitosan nanopar- ticles 显示文摘 | ANITHA A DIVYA RANI V KRISHNA R | 2009 | Carbohydrate polymers2009，78，4： | 1 |
| 6 | Laundry detergents: an overview显示文摘 | Bajpai Divya Tyagi V K | 2007 | Journal of oleo science2007，56，7： | 1 |
| 7 | Fatty imidazolines: chemistry, synthesis, properties and their industrial applications显示文摘 | Divya B tyagi V K | 2006 | Journal of Oleo Science2006，55，7： | 1 |
| 8 | Fabrication of chitin-chitosan/nano TiO2 -composite scaffolds for tissue engineering applications 显示文摘 | Jayakumar R Ramachandran R Divya Rani V V | 2011 | Int J Biol Macromol2011，48，2： | 1 |
| 9 | Fatty imidazoline: Chemistry, synthesis, properties and their industrial applications 显示文摘 | Divya Bajpai Tyagi V K | 2006 | J Oleo Sci2006，55，7： | 1 |
| 10 | Carbon fiberbismaleimide composites filled with nickel-coated singlewalled carbon nanotubes for lightning-strike protection显示文摘 | Divya K C Valery N K Ranji V | | 0，，： | 1 |
| 11 | Synthesis, characterization, cytotoxicity and antibacterial studies of chitosan, O-carboxymethyl and N,O- carboxymethyl chitosan nanoparticles显示文摘 | ANITHA A DIVYA R V V KRISHNA R | 2009 | Carbohydrate Polymers2009，78，4： | 1 |
| 12 | Fatty imidazolines: chemistry, synthesis, properties and their industrial applications显示文摘 | DIVYA B TYAGI V K | 2006 | Journal of oleo science2006，55，7： | 1 |
| 13 | Evaluation of Tensile Strength-Strain Characteristics of Fiber-Reinforced Soil through Laboratory Tests显示文摘 | DIVYA P V VISWANADHAM B V S GOURC J P | 2014 | Journal of Materials in Civil Engineer- ing2014，26，1： | 1 |
| 14 | Pseudospectral methods for solving infinite-horizon optimal control problems显示文摘 | Garg Divya Hager W W Rao A V | 2011 | Automatica2011，47，4： | 1 |
| 15 | Significance of platelet volumeindices and platelet count in ischaemic heart disease显示文摘 | Ranjith M P Divya R Mehta V K | 2009 | J Clin Path2009，62，： | 1 |
| 16 | Fabrication of alginate/nanoTiO2 needle composite scaffolds for tissue engineering applications显示文摘 | Divya Rania V V Ramachandrana R Chennazhia K P | 2011 | Carbohydrate Polymers2011，83，： | 1 |
| 17 | Crystallization studies and properties of (Ba1-xSrx)TiO3 in borositicate glass 显示文摘 | DIVYA P V KUMAR V | 2007 | Journal of American Ceramic Society2007，90，2： | 1 |
| 18 | Prohexadione, a plant growth regulator, inhibits histonelysine demethylases and modulates epigenetics 显示文摘 | Divya T V Sujatha R S | 2014 | Toxicology Reports2014，，1： | 1 |
| 19 | Crystallization studies and properties of(Ba1–xSrx)TiO3 in borosilicate glass显示文摘 | DIVYA P V KUMAR V | 2007 | J Am Ceram Soc2007，90，47： | 1 |
| 20 | Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrolic effect through regulation of collagen production against pulmonary fibrosis显示文摘 | Divya T Dineshbabu V Somnyakrishnan S | 2016 | Chem Biol Interact2016，246，： | 1 |
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