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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Carbonyl sulfide removal with compost and wood chip biofilters, and in the presence of hydrogen sulfide显示文摘 | Melanie L S Divya R G Chandraprakash S N | 2009 | Journal of the Air & Waste Management Association2009，59，12： | 1 |
| 3 | A review on current aspects and diverse prospects for enhancing hiogas production in sustainable means显示文摘 | D Divya L R Gopinath P Merlin Christy | 2015 | Renewable and Sus- tainable Energy Reviews2015，42，0： | 1 |
| 4 | Identifying theage cohort responsible for transmission in a natural outbreak of Bor-detella bronchiseptica显示文摘 | GRAINNE H L DIVYA S ANDREW F R | 2010 | PLoS Pathogens2010，6，12： | 1 |
| 5 | Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape 显示文摘 | Amber L J Hwajin K Divya S etal | | Proc Natl Acad Sci U S A0，，： | 1 |
| 6 | Ethyl p - methoxycinnamate iso- lated from a traditional anti - tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro 显示文摘 | Divya L Jim W Leny J | 2011 | Fitoterapia2011，82，5： | 1 |
| 7 | Kinetic and Equilibrium Characterization of Uranium (Ⅳ)Adsorption Onto Carboxylate-Functionalized PolyGrafted Lignocellulosics显示文摘 | Anirudhan T S Divya L Suchithra P S | | 0，，： | 1 |
| 8 | Kinetic and equilibrium characterization of uranium(Ⅵ) adsorption onto carboxylate-functionalized poly (hydroxyethylmethacrylate) -grafted lignocellulosics显示文摘 | Anirudhan T S Divya L Suchithra P S | 2009 | J Environmental Management2009，90，1： | 1 |
| 9 | Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms显示文摘 | Nilanjana C Divya S Mekonnen L D | 2011 | Nucleic Acids Research2011，39，19： | 1 |
| 10 | Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro显示文摘 | Divya L Jim W Leny J | 2011 | Fitoterapia2011，82，5： | 1 |
| 11 | Kinetic and equilib-rium characterization of uranium(VI)adsorption onto carboxylate-func-tionalized poly(hydroxyethylmethacrylate)-grafted lignocellulosics显示文摘 | ANIRUDHAN T S DIVYA L SUCHITHRA P S | 2009 | Journal of Environmental Management2009，90，1： | 1 |
| 12 | Synthesis and characterization of silane coated magnetic nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a drug carrier for the controlled delivery of 5-fluorouracil显示文摘 | ANIRUDHAN T S DIVYA P L NIMA J | 2015 | Mater Sci Eng C2015，55，： | 1 |
| 13 | Lyophilization/ Freeze Drying-An Review显示文摘 | NIREESHA G DIVYA L SOWMYA C | 2013 | International Journal of Novel Trends in Pharmcetical Science2013，3，4： | 1 |
| 14 | Low-grade endome- trial stromal sarcoma in young age: a clinicopathologieal report 显示文摘 | Jassal C D Patnaik B L Divya A Prasad S | 2012 | J Obstet Gynaecol India2012，62，1： | 1 |
| 15 | Antimicrobial Activity of Apple, Hibiscus, Olive, and Hydrogen Peroxide Formulations against Salmonella enterica on Organic Leafy Greens显示文摘 | Moore Katherine L Patel Jitendra Jaroni Divya Friedman Mendel Ravishankar Sadhana | 2011 | Journal of Food Protection2011，，10： | 1 |
| 16 | Antimi-crobial activity of apple,hibiscus,olive,and hydro-gen peroxide formulations against Salmonella entericaon organic leafy greens显示文摘 | Katherine L M Jitendra P Divya J | 2011 | Journal of Food Protection2011，74，10： | 1 |
| 17 | A review on anaerobic decomposition and enhancement of biogas production through enzymes and microorganisms显示文摘 | Merlin C P Gopinath L R Divya D | 2014 | Renewable and Sus- tainable Energy Reviews2014，34，： | 1 |
| 18 | In vitro differentiation of retinal gan- glion-like cells from embryonic stem cell derived neural progenitors显示文摘 | Jagatha B Divya M Sanalkumar R Chandrasekharan L Indulekha CL Vidyanand S | 2009 | Biochem Biophys Res Commun2009，380，2： | 1 |
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