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| 1 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 2 | The earthquake-related disturbances in ionosphere and project of the first China seismo-electromagnetic satellite显示文摘Based on the case studies and statistical analysis of earthquake-related ionospheric disturbances mainly from DEMETER satellite,ground-based GPS and ionosounding data,this paper summarizes the statistical characteristics of earthquake-related ionospheric disturbances,including electromagnetic emissions,plasma perturbations and variation of energetic particle flux.According to the main results done by Chinese scientists, fusing with the existed study from global researches,seismo-ionospheric disturbances usually occurred a few days or hours before earthquake occurrence.Paralleling to these case studies,lithosphere-atmosphere-ionosphere (LAI) coupling mechanisms are checked and optimized.A thermo-electric model was proposed to explain the seismo-electromagnetic effects before earthquakes.A propagation model was put forward to explain the electromagnetic waves into the ionosphere.According to the requirement of earthquake prediction research,China seismo-electromagnetic satellite,the first space-based platform of Chinese earthquake stereoscopic observation system,is proposed and planned to launch at about the end of 2014.It focuses on checking the LAI model and distinguishing earthquake-related ionospheric disturbance.The preliminary design for the satellite will adopt CAST-2000 platform with eight payloads onboard.It is believed that the satellite will work together with the ground monitoring network to improve the capability to capture seismo-electromagnetic information,which is beneficial for earthquake monitoring and prediction researches. | Xuhui Shen Xuemin Zhang Lanwei Wang Huaran Chen Yun Wu Shigeng Yuan Junfeng Shen Shufan Zhao Jiadong Qian Jianhai Ding | 2011 | Earthquake Science2011，24，6： | 13 |
| 3 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 4 | Removal of Cs+ from water and soil by ammonium-pillared montmorillonite/Fe3O4 composite显示文摘To remove cesium ions from water and soil, a novel adsorbent was synthesized by following a one-step co-precipitation method and using non-toxic raw materials. By combining ammonium-pillared montmorillonite(MMT) and magnetic nanoparticles(Fe_3O_4), an MMT/Fe_3O_4 composite was prepared and characterized. The adsorbent exhibited high selectivity of Cs^+ and could be rapidly separated from the mixed solution under an external magnetic field. Above all, the adsorbent had high removal efficiency in cesium-contaminated samples(water and soil) and also showed good recycling performance, indicating that the MMT/Fe_3O_4 composite could be widely applied to the remediation of cesium-contaminated environments. It was observed that the pH, solid/liquid ratio and initial concentration affected adsorption capacity. In the presence of coexisting ions, the adsorption capacity decreased in the order of Ca^(2+)> Mg^(2+)> K^+> Na^+, which is consistent with our theoretical prediction. The adsorption behavior of this new adsorbent could be expressed by the pseudo-second-order model and Freundlich isotherm. In addition, the adsorption mechanism of Cs^+ was NH_4^+ ion exchange and surface hydroxyl group coordination, with the former being more predominant. | Xianming Zheng Junfeng Dou Jing Yuan Wei Qin Xiaoxi Hong Aizhong Ding | 2017 | Journal of Environmental Sciences2017，29，6： | 10 |
| 5 | Anaerobic benzene biodegradation by a pure bacterial culture of Bacillus cereus under nitrate reducing conditions显示文摘A pure culture using benzene as sole carbon and energy sources was isolated by screening procedure from gasoline contaminated soil.The analysis of the 16S rDNA gene sequence,morphological and physiological characteristics showed that the isolated strain was a member of genus Bacillus cereus.The biodegradation performance of benzene by B.cereus was evaluated,and the results showed that benzene could be efficiently biodegraded when the initial benzene concentration was below 150 mg/L.The metabolites of anaerobic nitrate-dependent benzene oxidation by strain B.cereus were identified as phenol and benzoate.The results of substrate interaction between binary combinations for benzene,phenol and benzoate showed that the simultaneous presence of benzene stimulated the degradation of benzoate,whereas the addition of benzene inhibited the degradation of phenol.Benzene degradation by B.cereus was enhanced by the addition of phenol and benzoate,the enhanced effects were more pronounced at higher concentration.To our knowledge,this is the first report that the isolated bacterial culture of B.cereus can efficiently degraded benzene under nitrate reducing conditions. | Junfeng Dou Aizhong Ding Xiang Liu Yongchao Du Dong Deng Jinsheng Wang | 2010 | Journal of Environmental Sciences2010，22，5： | 6 |
| 6 | Phase demodulation method based on a dual-identical-chirped-pulse and weak fiber Bragg gratings for quasi-distributed acoustic sensing显示文摘A phase demodulation method for quasi-distributed acoustic sensing(DAS)systems based on a dual-identicalchirped-pulse and weak fiber Bragg gratings(WFBGs)is proposed.Compared to the use of Rayleigh backscattering light in optical fibers,the implementation of WFBGs can contribute to obtaining an optical signal with a higher signal-to-noise ratio(SNR).The dual-identical-chirped-pulse is generated by a time-delay fiber,and the sinusoidal carrier is generated by the interference between the two chirped pulses reflected by adjacent WFBGs.The phase of the sinusoidal carrier represents the dynamic strain change posed on the sensing fiber.Discrete Fourier transform is used to directly retrieve the phase information.The performance of the phase demodulation from interference signals under different sinusoidal carrier frequencies and SNRs is numerically investigated.The piezoelectric transducer is employed to emulate the sound in the experiment to verify the effectiveness of our method.It is shown that the dynamic strain can be well reconstructed at the end of a 101.64 km fiber when the signal SNR is down to 3.234 d B.Our proposed method enables the application of the long-distance sensing in quasi-DAS systems. | Guanhua Liang Junfeng Jiang Kun Liu Shuang Wang Tianhua Xu Wenjie Chen Zhe Ma Zhenyang Ding Xuezhi Zhang Yongning Zhang Tiegen Liu | 2020 | Photonics Research2020，8，7： | 6 |
| 7 | Effects of Elevated CO_2 and Drought on Plant Physiology, Soil Carbon and Soil Enzyme Activities显示文摘Global climate models have indicated high probability of drought occurrences in the coming future decades due to the impacts of climate change caused by a mass release of CO_2. Thus, climate change regarding elevated ambient CO_2 and drought may consequently affect the growth of crops. In this study, plant physiology, soil carbon, and soil enzyme activities were measured to investigate the impacts of elevated CO_2 and drought stress on a Stagnic Anthrosol planted with soybean(Glycine max). Treatments of two CO_2 levels, three soil moisture levels, and two soil cover types were established. The results indicated that elevated CO_2 and drought stress significantly affected plant physiology. The inhibition of plant physiology by drought stress was mediated via prompted photosynthesis and water use efficiency under elevated CO_2 conditions. Elevated CO_2 resulted in a longer retention time of dissolved organic carbon(DOC) in soil, probably by improving the soil water effectiveness for organic decomposition and mineralization. Drought stress significantly decreased C:N ratio and microbial biomass carbon(MBC), but the interactive effects of drought stress and CO_2 on them were not significant. Elevated CO_2 induced an increase in invertase and catalase activities through stimulated plant root exudation.These results suggested that drought stress had significant negative impacts on plant physiology, soil carbon, and soil enzyme activities,whereas elevated CO_2 and plant physiological feedbacks indirectly ameliorated these impacts. | WANG Yuhui YAN Denghua WANG Junfeng DING Yi SONG Xinshan | 2017 | Pedosphere2017，27，5： | 5 |
| 8 | The pulsed high magnetic field facility and scientific research at Wuhan National High Magnetic Field Center显示文摘Wuhan National High Magnetic Field Center(WHMFC)at Huazhong University of Science and Technology is one of the top-class research centers in the world,which can offer pulsed fields up to 90.6 T with different field waveforms for scientific research and has passed the final evaluation of the Chinese government in 2014.This paper will give a brief introduction of the facility and the development status of pulsed magnetic fields research at WHMFC.In addition,it will describe the application development of pulsed magnetic fields in both scientific and industrial research. | Xiaotao Han Tao Peng Hongfa Ding Tonghai Ding Zengwei Zhu Zhengcai Xia Junfeng Wang Junbo Han Zhongwen Ouyang Zhenxing Wang Yibo Han Houxiu Xiao Quanliang Cao Yiliang Lv Yuan Pan Liang Li | 2017 | Matter and Radiation at Extremes2017，2，6： | 5 |
| 9 | Influence of B,Al and Nb addition on the glass forming ability and stability of mechanically alloyed Zr-Ni amorphous alloys显示文摘We investigated the influence of minor additions of B,Al and Nb that have representative atomic sizes on the glass forming ability (GFA) and stability of Zr-Ni amorphous alloys during mechanical alloying. The results show that the minor addition of B,Al or Nb does not shorten the initial time of the full amorphization reaction or improve the glass forming ability of the Zr-Ni alloys at a low rotation speed. However,B addition can effectively improve the mechanical stability of the amorphous phase against mechanically induced crystallization. Furthermore,the amorphous phase gradually transforms into a metastable fcc-phase with increasing milling time. The addition of Al and Nb that have similar atomic sizes has a similar effect on the GFA and the mechani-cal stability of the Zr-Ni amorphous phase. Moreover,Al and Nb addition can alter the crystallization behavior and improve the thermal stability of the Zr-Ni amorphous phase. | WANG Yan DING JunFeng BAI YanWen | 2011 | Chinese Science Bulletin2011，56，36： | 5 |
| 10 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 11 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 12 | The Main Progress of Perovskite Solar Cells in 2020-2021显示文摘Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world.Both the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step.This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free PSCs.Moreover,a brief discussion on the development of PSC modules and its challenges toward practical application is provided. | Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 13 | Electrochemical degradation of perfluorooctanoic acid (PFOA) by Ti/SnO 2 –Sb, Ti/SnO 2 –Sb/PbO 2 and Ti/SnO 2 –Sb/MnO 2 anodes显示文摘 | Hui Lin Junfeng Niu Shiyuan Ding Lilan Zhang | 2012 | Water Research2012，，7： | 2 |
| 14 | Whole cell bioreporter application for rapid detection and evaluation of crude oil spill in seawater caused by Dalian oil tank explosion显示文摘 | Dayi Zhang Aizhong Ding Shuangchao Cui Cheng Hu Steven F. Thornton Junfeng Dou Yujiao Sun Wei E. Huang | 2012 | Water Research2012，，： | 1 |
| 15 | Challenges to China's transition to a low carbon electricity system显示文摘 | Fredrich Kahrl Jim Williams Ding Jianhua Hu Junfeng | | 0，，39： | 1 |
| 16 | An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease显示文摘 | Zhen Huang Jingjing Gan Lixin Jia Guangxing Guo Chunming Wang Yuhui Zang Zhi Ding Jiangning Chen Junfeng Zhang Lei Dong | 2015 | Biomaterials2015，，： | 1 |
| 17 | Genome Mining and Biosynthesis Study of a Type B Linaridin Reveals a Highly Versatileα-N-Methyltransferase显示文摘Linaridins are a small but growing family of natural products belonging to the ribosomally synthesized and post-translationally modified peptide(RiPP)superfamily.In this study,a genome mining approach led to the identification of a novel linaridin,mononaridin(MON),from Streptomyces monomycini.In-frame deletion genetic knockout studies showed that,in addition to many genes essential for MON biosynthesis,monM encodes an S-adenosyl methionine(SAM)-dependentα-N-methyltransferase that is responsible for installing two methyl groups in the MON N-terminus.Besides SAM,MonM also accepts ethyl-SAM and allyl-SAM,in which the methyl of SAM is replaced by an ethyl and an allyl,respectively.We showed that ethyl-SAM and allyl-SAM have distinct reactivities in MonM catalysis,and this observation was further investigated in detail by density functional theory(DFT)calculations.Remarkably,MonM acts efficiently on nisin,a prototypic lantibiotic that is structurally very different from the native substrate,and the ability of MonM to transfer an allyl group to the nisin N-terminus allowed production of a fluorescently labeled nisin,which can be further used in microscopic cell analysis.Our studies provide new insights into linaridin biosynthesis and demonstrate the potential of linaridin methyltransferases in bioengineering applications. | Fangting Wang Wanqing Wei Junfeng Zhao Tianlu Mo Xin Wang Xuedong Huang Suze Ma Shu Wang Zixin Deng Wei Ding Yong Liang Qi Zhang | 2021 | CCS Chemistry2021，3，3： | 1 |
| 18 | Anaerobic degradation of naphthalene by the mixed bacteria under nitrate reducing conditions 显示文摘 | DOU Junfeng LIU Xiang DING Aizhoug | 2009 | Journal of Hazardous Materials2009，165，： | 1 |
| 19 | Preparation and properties of Ti/SnO2-Sb205 electrodes by electrodeposition 显示文摘 | Ding Haiyang Feng Yujie Liu Junfeng | 2007 | Materials Letters2007，61，27： | 1 |
| 20 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
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