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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | The CELLULOSE-SYNTHASE LIKE C (CSLC) Family of Barley Includes Members that Are Integral Membrane Proteins Targeted to the Plasma Membrane显示文摘纤维素象 SYNTHASE 一样 C (CSLC ) 家庭是在被认为在苔藓和脉管的植物的分叉前产生了的 CELLULOSE SYNTHASE/CELLULOSE 象 SYNTHASE 一样(CESA/CSL ) 多糖 synthase 总科以内的一个古老的系。作为在 flowering 植物的研究, Arabidopsis 建议了合成( 1,4 )-- xyloglucan ( XyG )的 glucan 脊梁,,拴住邻近的纤维素 microfibrils 到对方的墙多糖为 CSLC 的可能的功能, CSLC 功能在大麦( Hordeum vulgare L.)被调查,有在它的墙中的 XyG 的低数量的种。四大麦 CSLC 基因被识别(指明的 HvCSLC14 ) 。种系发生的分析在 flowering 植物揭示 CSLC 的三很好支持的 clades,与有在二这些 clades 的代表的大麦。四大麦 CSLC 在各种各样的纸巾被表示,与,包括有主要、第二等的房间墙的房间在在所有房间检测抄本的 situ PCR coleoptile 和根打字。合作表示分析证明 HvCSLC3 并列地与通常认为的 XyG xylosyltransferase 基因被表示。两免疫 -- 他们和膜分别证明 HvCSLC2 位于大麦的血浆膜暂停有教养的房间并且不在象 endoplasmic 那样的内部膜蜂窝胃或 Golgi 仪器。基于我们多糖合成的亚 cellular 地点的当前的知识,我们断定 CSLC 家庭可能包含多糖 synthase 的超过一种类型。 | Fenny M. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah M. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin Monika S. Doblin | 2009 | Molecular Plant2009，2，5： | 2 |
| 3 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs 显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，20： | 1 |
| 4 | Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs显示文摘 | Bragonzi A Dina G Villa A | 2000 | Gene Ther2000，7，20： | 1 |
| 5 | Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear Factor-KB and activator protein 1 in a redox- sensitive manner显示文摘 | Michael Browatzki Dina Larsen Carolein A H Pfeiffer | 2005 | JVR2005，42，4： | 1 |
| 6 | Detection of the new human eoronavirus HKUI: a report of 6 cases显示文摘 | Vabret A Dina J Gouarin S | 2006 | Clin Infect Dis2006，42，： | 1 |
| 7 | Detection of the new human coronavirus HKUI: a report of 6 cases 显示文摘 | Vabret A Dina J Gouarin S | 2006 | Clin Infect Dis2006，42，5： | 1 |
| 8 | Human(non-severe aeute respiratory syndrome) coronavirus infections in hospitalised children in France显示文摘 | Vabret A Dina J Gouarin S | | 0，，04： | 1 |
| 9 | Copper and hepatocellular carcinoma显示文摘 | Vecchio F M Federico F Dina M A | 1986 | Digestion1986，35，2： | 1 |
| 10 | The role of vascular endothelial growth factor in Langerhans cell histiocytosis显示文摘 | Dina A Zahava V Iness M | 2005 | J Pediatr Hematol Oncol2005，27，2： | 1 |
| 11 | Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03) 显示文摘 | Le Clerc S Limou S Coulonges C Carpentier W Dina C Taing L Delaneau O Labib T Sladek R ANRS Genomic Group Deveau C Guillemain H Ratsimandresy R Montes M Spadoni JL Therwath A Schichter F Matsuda F Gut I Leli6vre JD L6vy Y Froguel P Delfraissy JF Hercberg S Zagury JF | 2009 | Infect Dis2009，200，8： | 1 |
| 12 | QTL analysis of quantita- tive resistance to Phytophthora infestans (late blight) in tomato and comparisons with potato显示文摘 | Douglas J B Elizabeth S J Dina A S C | 2004 | Proquest Agriculture Journals2004，47，3： | 1 |
| 13 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 14 | Clinical Evaluation of the ASPAN Pain and Comfort Clinical Guideline显示文摘 | Dina A K Linda W Robin N | 2004 | Journal of Perianesthesia Nursing2004，19，3： | 1 |
| 15 | D-dimer levels following single twin death:A case report and review of the literature显示文摘 | Daniilidis A Sardel C Dinas K | 2010 | Eur J Obstet Gynecol Reprod Biol2010，148，1： | 1 |
| 16 | Detection of the new human coronavirus HKUI: a report of 6 cases显示文摘 | Vabret A Dina J Gouarin S | 2006 | Clin Infect Dis2006，42，： | 1 |
| 17 | QTL analysis of quantitative resistance to Phytophthora infestans (late blight) in tomato and comparisons with potato显示文摘 | Douglas J B Elizabeth S J Dina A S C | 2004 | Proquest Agriculture Journals2004，47，3： | 1 |
| 18 | An Affordance-based Approach to Architectural Theory, Design, and Practice显示文摘 | MAIER Jonathan R A FADEL Georges M BATTISTO Dina G | 2009 | Design Studies2009，30，4： | 1 |
| 19 | Direct and indirect recognition: the role of MHC antigens in graft rejection显示文摘 | Dina SG Hugh A | 1999 | Immunology Today1999，20，2： | 1 |
| 20 | Two new Loci for body- weight regulation identified in a joint analysis of genome-wide association studies forearly-onset extreme obesity in French and german study groups显示文摘 | Seherag A Dina C Hinney A | 2010 | PLoS Genet2010，6，： | 1 |
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