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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Challenges in diagnosing mesenteric ischemia显示文摘Early identification of acute mesenteric ischemia (AMI) is challenging. The wide variability in clinical presentation challenges providers to make an early accurate diagnosis. Despite major diagnostic and treatment advances over the past decades, mortality remains high. Arterial embolus and superior mesenteric artery thrombosis are common causes of AMI. Non-occlusive causes are less common, but vasculitis may be important, especially in younger people. Because of the unclear clinical presentation and non-specific laboratory findings, low clinical suspicion may lead to loss of valuable time. During this diagnostic delay, progression of ischemia to transmural bowel infarction with peritonitis and septicemia may further worsen patient outcomes. Several diagnostic modalities are used to assess possible AMI. Multi-detector row computed tomographic angiography is the current gold standard. Although computed tomographic angiography leads to an accurate diagnosis in many cases, early detection is a persistent problem. Because early diagnosis is vital to commence treatment, new diagnostic strategies are needed. A non-invasive simple biochemical test would be ideal to increase clinical suspicion of AMI and would improve patient selection for radiographic evaluation. Thus, AMI could be diagnosed earlier with follow-up computed tomographic angiography or high spatial magnetic resonance imaging. Experimental in vitro and in vivo studies show promise for alpha glutathione S transferase and intestinal fatty acid binding protein as markers for AMI. Future research must confirm the clinical utility of these biochemical markers in the diagnosis of mesenteric ischemia. | Teun C van den Heijkant Bart AC Aerts Joep A Teijink Wim A Buurman Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，9： | 31 |
| 3 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 4 | 大别山双河和碧溪岭超高压变质岩流体包裹体研究显示文摘对大别山双河和碧溪岭含柯石英榴辉岩和硬玉石英岩进行了详细的流体包裹体研究。根据流体包裹体的成分和盐度的不同 ,可以划分出至少五种类型不同的气液包裹体 :( 1) N2 包裹体 ;( 2 )高盐度流体包裹体 ;( 3) CO2 包裹体 ;( 4) CO2 -H2 O包裹体 ;( 5 )低盐度流体包裹体。N2 包裹体仅见于含柯石英榴辉岩 ,而高盐度流体包裹体则几乎存在于所有的榴辉岩和硬玉石英岩中。 CO2 包裹体沿榴辉岩中微剪切带分布 ,或存在于强变形的硬玉石英岩中 ,而低盐度流体包裹体分布较为局限。N2 和高盐度流体被认为是超高压变质作用平衡的产物 ,来源于变质前的古孔隙流体。而且榴辉岩中含有一系列盐度不同的流体显微域 ,其大小与矿物颗粒相当。在板块折返过程中 ,包裹体中流体可能发生迁移 ,但是不会超出寄主晶体的范围。CO2流体明显是外来的 ,可能来自共生大理岩或含碳酸盐的变质沉积岩。这与菱镁矿和柯石英等共生组合所指示的进变质过程中大理岩不存在脱碳反应的结论相一致。而低盐度流体则可能系顶峰变质矿物分解而成 。 | 傅斌 肖益林 J L R Touret A M Van den Kerkhof JHoefs 郑永飞 | 2000 | 岩石学报2000，16，1： | 14 |
| 5 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 6 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 7 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 8 | Intensive insulin therapy in the medical ICU显示文摘 | Van den Berghe G Wilmer A Hermans G | | New England Journal of Medicine0，，： | 3 |
| 9 | Embankment Widening with the Gap-method 显示文摘 | A N G Van Meurs A Van Den Berg et | 1999 | Rotterdam:Geotechnical Engineering for Transportation Infrastructure1999，，： | 2 |
| 10 | Medical image matching-a review with classification 显示文摘 | VAN DEN ELSEN P A POL E J D VIERGEVER M A | 1993 | IEEE Eng in Med & Biol1993，12，1： | 2 |
| 11 | Intensive insulin therapy in mixed medical/surgical intensive care units:benefit versus harm显示文摘 | Van den Berghe G Wilmer A Milants I | | Diabetes0，，： | 2 |
| 12 | 多病并存的多重挑战 这个时代已经到来——关注日益增长的脆弱人群的需求显示文摘多病并存(或称多重病)现象在初级卫生保健中已不是个别现象。最近在加拿大魁北克省沙格奈河地区进行的一项有21个社区医院参加的研究表明,在18~44岁组多重病的患病率为69%,45~64岁组为93%,65岁以上组达到98%,患慢性病的个数在年轻组为2.8而在老年组升至6.4。其他国家也报告了类似的疾病负担状况,如美国多病并存的患者人数将由2000年的6000万上升到2020年的8100万。 | Martin Fortin Hassan Soubhi Catherine Hudon Elizabeth A Bayliss Marian van den Akker 赛晓勇 | 2007 | 英国医学杂志中文版2007，10，5： | 2 |
| 13 | CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice显示文摘 | Medina-Contreras Oscar Geem Duke Laur Oskar Williams Ifor R Lira Sergio A Nusrat Asma Parkos Charles A Denning Timothy L | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 14 | Deep drawing simulations of Tailored Blanks and experimental verification 显示文摘 | MEINDERS T VAN DEN BERG A HUETINK J | 2000 | Journal of Materials Processing Technology2000，103，： | 2 |
| 15 | Experimental and theoretical study of the swirling flow in centrifugal compressor volute显示文摘 | Van den Braembussche R A Hand B M | 1990 | ASME Journal of Turbornachinery1990，112，3： | 2 |
| 16 | A cooperative approach to particle swarm optimization 显示文摘 | Van den Bergh F Engelbrech A P | 2004 | IEEE Trans on Evolutionary Computation2004，8，3： | 1 |
| 17 | The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and eoronaviruses are evolutionarily related 显示文摘 | Snijder E J den Boon J A Bredenbeek P J | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 18 | Measuring mechanical properties of coating: a methodology applied to nano-particlefilled sol-gel coating on glass显示文摘 | MALZBENDER J DEN TOONDER J M J BALKENENDE A R | 2002 | Mater Sei Eng R2002，36，： | 1 |
| 19 | Modeling of intelligent pressure sensor using functional link artificial neural networks 显示文摘 | Patra J C Bos A Van Den | 2000 | ISA Transactions2000，，9： | 1 |
| 20 | Intensive Insulin Therapy in the Medical ICU显示文摘 | Van den Berghe G Wilmer A Hermans G | 2006 | N Ensl J Med2006，354，5： | 1 |
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