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| 1 | Ilizarov bone transport combined with the Masquelet technique for bone defects of various etiologies (preliminary results)显示文摘BACKGROUND The Ilizarov bone transport(IBT)and the Masquelet induced membrane technique(IMT)have specific merits and shortcomings,but numerous studies have shown their efficacy in the management of extensive long-bone defects of various etiologies,including congenital deficiencies.Combining their strong benefits seems a promising strategy to enhance bone regeneration and reduce the risk of refractures in the management of post-traumatic and congenital defects and nonunion that failed to respond to other treatments.AIM To combine IBT and IMT for the management of severe tibial defects and pseudarthrosis,and present preliminary results of this technological solution.METHODS Seven adults with post-traumatic tibial defects(subgroup A)and nine children(subgroup B)with congenital pseudarthrosis of the tibia(CPT)were treated with the combination of IMT and IBT after the failure of previous treatments.The mean number of previous surgeries was 2.0±0.2 in subgroup A and 3.3±0.7 in subgroup B.Step 1 included Ilizarov frame placement and spacer introduction into the defect to generate the induced membrane which remained in the interfragmental gap after spacer removal.Step 2 was an osteotomy and bone transport of the fragment through the tunnel in the induced membrane,its compression and docking for consolidation without grafting.The outcomes were retrospectively studied after a mean follow-up of 20.8±2.7 mo in subgroup A and 25.3±2.3 mo in subgroup B.RESULTS The“true defect”after resection was 13.3±1.7%in subgroup A and 31.0±3.0%in subgroup B relative to the contralateral limb.Upon completion of treatment,defects were filled by 75.4±10.6%and 34.6±4.2%,respectively.Total duration of external fixation was 397±9.2 and 270.1±16.3 d,including spacer retention time of 42.4±4.5 and 55.8±6.6 d,in subgroups A and B,respectively.Bone infection was not observed.Postoperative complications were several cases of pin-tract infection and regenerate deformity in both subgroups.Ischemic regeneration was observed in two cases of subgroup B.Complications were corrected during the course of treatment.Bone union was achieved in all patients of subgroup A and in seven patients of subgroup B.One non-united CPT case was further treated with the Ilizarov compression method only and achieved union.After a follow-up period of two to three years,refractures occurred in four cases of united CPT.CONCLUSION The combination of IMT and IBT provides good outcomes in post-traumatic tibial defects after previous treatment failure but external fixation is longer due to spacer retention.Refractures may occur in severe CPT. | Dmitry Y Borzunov Sergey N Kolchin Denis S Mokhovikov Tatiana A Malkova | 2022 | World Journal of Orthopedics2022，13，3： | 6 |
| 2 | Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements显示文摘Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating factors.Each of the various strategies currently employed to face these scourges is seriously inadequate.Despite enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented.Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden.Nowadays,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently used.The recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease. | Denis Zofou Raymond B Nyasa Dickson S Nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete | 2014 | Infectious Diseases of Poverty2014，3，1： | 4 |
| 3 | Density functional investigation of atmospheric sulfur chemistry Ⅱ: The heat of formation of the XSO2 radical X=H, CH3 显示文摘 | Denis P A Ventura O N | 2001 | Chem Phys Lett2001，344，： | 2 |
| 4 | Transformation kinetics and microstructures of Ti17 titanium alloy during continuous cooling显示文摘 | TEIXEIRA J APPOLAIRE B AEBY-GAUTIER E DENIS S CAILLETAUD G SPAAETH N | 2007 | Materials Science and Engineering A2007，448，12： | 1 |
| 5 | Low level of dopmnin- ergieD2 receptor binding in obsessive-compulsive disorder显示文摘 | Denys D Van Oler Ween N Jansen J | 2005 | Biol Payehiatry2005，54，： | 1 |
| 6 | Low level of do- paminergic D2 receptor binding in obsessive - compulsive disorder显示文摘 | Denys D Van Oler - Ween N Janssen J | 2010 | Biol Paychiatry2010，54，2： | 1 |
| 7 | Absolute radiometric calibration of the RapidEye multispectral imager using the reflectance-based vicarious calibration method显示文摘 | DENIS N ANDREAS B JEFF C M | | 0，，： | 1 |
| 8 | 显示文摘 | Harvey S N Denis C W Clifford M K | 1996 | Proc SPIE1996，2842，： | 1 |
| 9 | Conservative management of pancreatic fistula after pancreaticoduodenectomy with pancreaticogastrostomy显示文摘 | Munoz-Bongrand N Sauvanet A Denys A | 2004 | J Am Coll Surg2004，199，2： | 1 |
| 10 | Interaction at the organic/ inorganic interface :Binding motifs for phosphonates at the surface of barite crystals显示文摘 | Black Simon N Bromley Lindsay A Cottler Denis | 1991 | J Chem Soc Faraday Trans1991，87，20： | 1 |
| 11 | Experimental violation of a Bell’s inequality in time with weak measurement显示文摘 | Palacios-laloy Agustin Mallet Fran?ois Nguyen Fran?ois Bertet Patrice Vion Denis Esteve Daniel Korotkov Alexander N | 2010 | Nature Physics2010，，6： | 1 |
| 12 | The intra-annual variability of soft-bottom macrobenthos abundance patterns in the North Channel of the Seine estuary 显示文摘 | Desroy N Janson A L Denis L | 2007 | Hydrobiologia2007，588，1： | 1 |
| 13 | Genetic variability of encephalomyocarditis virus (EMCV) isolates 显示文摘 | Denis P Liebig H D Nowotny N | 2006 | Vet Microbiol2006，113，： | 1 |
| 14 | Influence of aminosilane surface fimctionalization of rare earth hydride-forraing alloys on palladium treatment by electroless deposition and hydrogen sorption kinetics of composite materials 显示文摘 | WILLIAMS M NECHAEV A N LOTOTSKY M V YARTYS V A SOLBERG J K DENYS R V PINEDA C LI Q LINKOV V M | 2009 | Mater Chem Phys2009，115，1： | 1 |
| 15 | Blended power management strategy using pattern recognition for a plug-in hybrid electric vehicle显示文摘 | DENIS N DUBIOS M R DUBE R | 2014 | International Journal of Intelligent Transportation Systems Research2014，，： | 1 |
| 16 | Conservative management of pancreatic fistula after pancreaticoduodenectomy with pancreaticogastrostomy 显示文摘 | Munoz-Bongrand N Sauvanet A Denys A | 2004 | J Am Coll Surg2004，199，2： | 1 |
| 17 | Influence of spring phytodetritus sedimentation on intertidal macrozoohenthos in the eastern English channel 显示文摘 | Desroy N Denis L | 2004 | Marine Ecology Progress Series2004，270，： | 1 |
| 18 | Highly efficient, practical approach to natural taxol显示文摘 | Denis J N Greene A E Guenard D | 1988 | J Am Chem Soc1988，110，17： | 1 |
| 19 | Interaction of foot placement, trunk frontal position, weight-bearing and knee moment asymmetry at seat-off when rising from a chair in healthy controls and the persons with hemiparesis 显示文摘 | Julie L Sylvie N Denis G | 2008 | J Rehabil Med2008，40，3： | 1 |
| 20 | The intra annual variability of soft-bottom macrobenthos abundance patterns in the North Channel of the Seine Estuary显示文摘 | DESROY N JANSON A L DENIS L | 2007 | Hydrobiologia2007，588，： | 1 |
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