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| 1 | Acute calculous cholecystitis: Review of current best practices显示文摘Acute calculous cholecystitis(ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery. Laparoscopic cholecystectomy is the best treatment for ACC and the procedure should ideally be performed within 72h. Early surgery is associated with better results in comparison to delayed surgery. In addition, when to suspect associated common bile duct stones and how to treat them when found are still debated. The antimicrobial agents are indicated for high-risk patients and especially in the presence of gallbladder necrosis. The use of broad-spectrum antibiotics and in some cases with antifungal agents is related to better prognosis. Moreover, an emerging strategy of not converting to open, a difficult laparoscopic cholecystectomy and performing a subtotal cholecystectomy is recommended by adept surgical teams. Some authors support the use of percutaneous cholecystostomy as an alternative emergency treatment for acute Cholecystitis for patients with severe comorbidities. | Carlos Augusto Gomes Cleber Soares Junior Salomone Di Saveiro Massimo Sartelli Michel Denis Kelly Camila Couto Gomes Felipe Couto Gomes Lívia Dornellas Correa Camila Brandao Alves Samuel de Fádel Guimaraes | 2017 | World Journal of Gastrointestinal Surgery2017，9，5： | 18 |
| 2 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 3 | Correlation between water diffusion and adhesion loss: Study of an epoxy primer on steel显示文摘 | Elise Legghe Emmanuel Aragon Léna?k Bélec André Margaillan Denis Melot | 2009 | Progress in Organic Coatings2009，，3： | 2 |
| 4 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 5 | Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant Chemotherapy显示文摘 | Henry Bismuth René Adam Fran?is Lévi Christian Farabos Fabio Waechter Denis Castaing Pietro Majno Luc Engerran | 1996 | Annals of Surgery1996，，4： | 2 |
| 6 | Tumor Marker Evolution: Comparison with Imaging for Assessment of Response to Chemotherapy in Patients with Colorectal Liver Metastases显示文摘 | Robbert J. Haas Dennis A. Wicherts Eduardo Flores Michel Ducreux Francis Lévi Bernard Paule Daniel Azoulay Denis Castaing Antoinette Lemoine René Adam | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 7 | Hepatic tumors: detection and characterization at 1-T MR imaging enhanced with AMI-25 显示文摘 | Denys A Arrive L Servois V | 1994 | Ra diology1994，193，3： | 1 |
| 8 | Gertain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogeneses of prostate cancer显示文摘 | Griffitha K Morton M S Denis L | 1999 | Eur Urol1999，35，： | 1 |
| 9 | Approximation algorithms for scheduling malleable tasks under precedence constraints显示文摘 | RENAUD L DENIS T GERHARD J W | 2002 | International Journal of Foundations of Computer Science2002，13，4： | 1 |
| 10 | Protection mechanisms in t he resurrection plant xerophyte viscosa: cloning, expression, characterisation and role of XvINO1, a gene coding for a myo-inositol 1-phosphate synthase显示文摘 | ARNAUD L DENIS R C | 2008 | Functional Plant Biology2008，35，1： | 1 |
| 11 | on intedeukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication显示文摘 | Denies S Ckelcao L Vm Audenhove I | 2014 | J Control Release2014，187，： | 1 |
| 12 | Low dose octretide and tamoxifen in the treatment of the pancreas显示文摘 | Rosenberg L Barkun An Denis MH | 1995 | Cancer1995，75，： | 1 |
| 13 | Apparent diffusion coefficient as an MR imaging biomarker of low-risk ductal carcinoma in situ: a pilot study 显示文摘 | Mami L Denis LB Ryosuke O | 2011 | Radiology2011，260，2： | 1 |
| 14 | Iterative weighted maximum likelihood denoising with probabilistic patch-based weights显示文摘 | Deledalle CA Denis L Tupin F | 2009 | IEEE Transactions on Image Processing2009，18，12： | 1 |
| 15 | Mitochondrial biogenesis during skeletal muscle regeneration显示文摘 | Duguez S Féasson L Denis C | 2002 | Am J Physiol Endocrinol Metab2002，282，4： | 1 |
| 16 | Essential interactions between Thiobacillus ferrooxidans and heterotrophic microorganisms during a wastewater sludge bioleaching process显示文摘 | Real L Denis C | 1998 | Environmental pollution1998，101，： | 1 |
| 17 | Genetically engineered immunity to papaya ringspot virus in Australian papaya cultures显示文摘 | Rosemarie E L Denis P James L D | 2002 | Molecular Breeding2002，10，： | 1 |
| 18 | Cellular cholesterol homeostasis in vascular endothelial cells显示文摘 | Hassan HH Denis M Krimbou L | 2006 | Can J Cardiol2006，22，： | 1 |
| 19 | Voltage stability analysis of mulfi-infeed HVDC systems显示文摘 | Denis L H A Andersson G | 1997 | IEEE Transactions on Power Delivery1997，12，3： | 1 |
| 20 | Iterative weighted maximum likelihood denoising with probabilistic patch-based weights显示文摘 | Deledalle C A Denis L and Tupin F | 2009 | IEEE Transactions on Image Processing2009，18，12： | 1 |
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