|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ion Channels in Mesenchymal Stem Cells from Rat Bone Marrow显示文摘 | Li GR Deng XL Sun H Chung SS Tse HF Lau CP | 2006 | 中国生物学文摘2006，20，5： | 18 |
| 2 | An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants显示文摘Abscisic 酸(骆驼毛的织物) 是最重要的荷尔蒙让植物抵抗干旱和另外的不能生活的压力。骆驼毛的织物直接绑在骆驼毛的织物受体的 PYR/PYL 家庭,导致类型 2C 磷酸酶(PP2C ) 和下游的骆驼毛的织物发信号的激活的抑制。骆驼毛的织物由小分子发信号的干预能帮助植物克服象干旱,寒冷和土壤咸度那样的不能生活的压力,这被想象。然而,由植物酶的化学不稳定性和快速的分解代谢限制骆驼毛的织物本身的实际申请。这里,我们报导一件小分子骆驼毛的织物的鉴定模仿(AM1 ) 那充当骆驼毛的织物受体的家庭的多重成员的有势力使活跃之物。在 Arabidopsis, AM1 激活高度类似于由骆驼毛的织物导致了那的一个基因网络。有 AM1 的处理禁止种子萌芽,阻止叶水损失,并且支持干旱抵抗。我们与 PYL2 骆驼毛的织物受体和 HAB1 PP2C 在建筑群解决了 AM1 的水晶结构,它表明 AM1 调停交往的 gate-latch-lock 网络,在骆驼毛的织物界限 receptor/PP2C 建筑群被保存的一个结构的特征。一起,这些结果证明一件单个小分子骆驼毛的织物模仿能激活多重骆驼毛的织物受体并且保护植物免受水损失和干旱应力的伤害。而且, AM1 复杂水晶结构为设计 ABA-mimicking 小分子的下一代提供一个结构的基础。 | Minjie Cao Xue Liu Yan Zhang Xiaoqian Xue X EdwardZhou Karsten Melcher Pan Gao Fuxing Wang Liang Zeng Yang Zhao Pan Deng Dafang Zhong Jian-Kang Zhu H Eric Xu Yong Xu | 2013 | Cell Research2013，23，8： | 17 |
| 3 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 4 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 5 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 6 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 7 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 8 | 新型冠状病毒感染合并高血压住院患者使用肾素血管紧张素系统阻断剂与病重及死亡风险的相关性显示文摘目前,缺乏关于新型冠状病毒疾病(coronavirus disease 2019,COVID-19)合并高血压患者在住院期间使用血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)或血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)是否增加病重或死亡风险的数据。本研究回顾性纳入2020年1月15日至3月15日于武汉中心医院住院的COVID-19患者1 178例。 | 袁源(摘译) 叶鹏(审校) Li J Wang X Chen J Zhang H Deng A | 2020 | 中华高血压杂志2020，28，6： | 6 |
| 9 | Journal of Viral Hepatitis|血清HBV RNA可预测经NUC治疗的慢性乙型肝炎患者的HBeAg清除和转换显示文摘HBV感染一直是全球公共卫生挑战。HBeAg阳性CHB接受NUC治疗后实现HBeAg清除或转换,提示患者获得部分免疫控制,是HBsAg清除或血清转换的先决条件。寻找可精准预测NUC治疗下HBeAg清除或转换的标志物,有重要临床意义。首都医科大学附属北京佑安医院郑素军教授团队联合北京大学基础医学院鲁凤民教授团队发现基线、NUC治疗6及12个月时低水平血清HBV RNA可精准预测CHB接受长期NUC治疗的HBeAg清除和转换。 | 王扬 郑素军 鲁凤民 WANG Y LIAO H DENG Z | 2022 | 临床肝胆病杂志2022，38，8： | 6 |
| 10 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 11 | MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice显示文摘 | Callis Thomas E Pandya Kumar Seok Hee Young Tang Ru-Hang Tatsuguchi Mariko Huang Zhan-Peng Chen Jian-Fu Deng Zhongliang Gunn Bronwyn Shumate Janelle Willis Monte S Selzman Craig H Wang Da-Zhi | 2009 | Journal of Clinical Investigation2009，，9： | 3 |
| 12 | 中国内地孕妇和家畜弓形虫的血清反应回顾性分析显示文摘弓形虫是一种引起弓形虫病的胞内原虫寄生虫。这种寄生虫在世界上分布广泛,可以感染多种温血动物,包括人类、宠物和家畜。在一般人群中,弓形虫感染可以保持无症状,也可引起淋巴结病和流感样症状,或导致眼疾,而最常发生的是绒毛膜炎,孕妇是其特定的风险群体。如果怀孕期间获得初级感染,可能导致胎儿流产、死产和神经发育障碍。在人群中的主要传播途径之一是食用含有T.gondii组织囊肿的生肉或未煮熟的肉类。 | Deng H F Devleesschauwer B Liu M | 2018 | 中国妇幼健康研究2018，29，6： | 3 |
| 13 | 鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大,以及低盐膳食模式与高血压的患病率和控制率相关显示文摘食物对高血压患病率和控制率的影响尚不清晰。本文旨在中国人群中调查鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大以及低盐膳食模式是否与高血压有关。方法:从2012年9月到2014年12月共招募15303名受试者进行病例对照研究,分为高血压组(n=1604)和正常血压组(n=13660),其中高血压组又分为血压控制亚组(n=397)和血压未控制亚组(n=1207)。收集过去1 年里每周平均鱼、蛋、牛奶、坚果、蔬菜、水果和盐摄入量数据。鱼、蛋、牛奶、坚果、蔬菜、水果和盐的平均摄入量分别为117、150、35、20、2100、300和58g/周。 | Yu G Fu H Huang W Zhang N Deng D Li G Lei H | 2019 | 中华高血压杂志2019，27，5： | 2 |
| 14 | The most appropriate category of metastatic lymph nodes to evaluate overall survival of gastric cancer following curative resection显示文摘 | Deng JY Liang H Sun D | | 0，，05： | 2 |
| 15 | A novel Ru-B/SiO_2 amorphous catalyst used in benzene-selective hydrogenation显示文摘 | Xie S H Qiao M H Li H X Wang W J Deng J-F | | 0，，： | 2 |
| 16 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 17 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 18 | Morphology and electrochemical activity of Ru-Ti-Sn ternary-oxide electrodes in 1M NaCl solution显示文摘 | Deng T S Bing J H | 1993 | Electrochem Acta1993，38，15： | 2 |
| 19 | Change of genetic architecture in response to sex显示文摘 | DENG H W LYNCH M | 1996 | Genetics1996，143，： | 1 |
| 20 | Sorption and Desorption of Lead (Ⅱ) Form Wastewater by Green Algae Cladophora Fascicularis显示文摘 | Deng L P Su Y Y Su H | 2007 | Journal of Hazardous Materials2007，143，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员